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Isoscoparins R and S, two new ent-clerodane diterpenoids from Isodon scoparius 期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2019, 卷号: 21, 期号: 10, 页码: 977-984
作者:  Li, Xing-Ren;  Fu, Qiang;  Zhou, Min;  Hu, Kun;  Du, Xue;  Li, Xiao-Nian;  Sun, Han-Dong;  Yue, Jian-Bo;  Zhang, Hong-Bin;  Puno, Pema-Tenzin
浏览  |  Adobe PDF(1263Kb)  |  收藏  |  浏览/下载：283/61  |  提交时间：2019/10/28
Lamiaceae  ent-clerodane diterpenoids  Isodon scoparius  X-ray diffraction  autophagic activity  
Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier for the Treatment of Brain Tumors 期刊论文
PHARMACEUTICS, 2019, 卷号: 11, 期号: 9, 页码: 16
作者:  Sajesh, Babu, V;  On, Ngoc H.;  Omar, Refaat;  Alrushaid, Samaa;  Kopec, Brian M.;  Wang, Wei-Guang;  Sun, Han-Dong;  Lillico, Ryan;  Lakowski, Ted M.;  Siahaan, Teruna J.;  Davies, Neal M.;  Puno, Pema-Tenzin;  Vanan, Magimairajan Issai;  Miller, Donald W.
浏览  |  Adobe PDF(3895Kb)  |  收藏  |  浏览/下载：252/63  |  提交时间：2019/12/20
blood-brain barrier (BBB)  drug delivery  transient modulation  HAV6 cadherin peptide  adenanthin  magnetic resonance imaging (MRI)  medulloblastoma  
Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 365, 页码: 71-83
作者:  Wang, Jing-Nan;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan;  Zhang, Zhi-Rong;  Li, Ning;  Li, Ren-Da;  Wan, Jun;  Sun, Han-Dong;  Sun, Nan;  Puno, Pema-Tenzin;  He, Jie
浏览  |  Adobe PDF(3457Kb)  |  收藏  |  浏览/下载：350/77  |  提交时间：2019/03/18
Acetyl-macrocalin B  Reactive oxygen species  p38 MAPK  Chk1/Chk2  Esophageal squamous cell carcinoma  
Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer 期刊论文
CANCER BIOLOGY & THERAPY, 2018, 卷号: 19, 期号: 7, 页码: 609-621
作者:  Wang, Jing-Nan;  Zhang, Zhi-Rong;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan;  Li, Ning;  Wan, Jun;  Sun, Han-Dong;  Sun, Nan;  Puno, Pema-Tenzin;  He, Jie
收藏  |  浏览/下载：227/0  |  提交时间：2018/07/16
Acetyl-macrocalin B  reactive oxygen species  p38 MAPK  apoptosis  Chk1  Chk2  G2  M phase arrest  NSCLC  
The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects 期刊论文
CANCER RESEARCH, 2017, 卷号: 77, 期号: 4, 页码: 926-936
作者:  Sun, Xiaoyan;  Wang, Weiguang;  Chen, Jiao;  Cai, Xueting;  Yang, Jie;  Yang, Yang;  Yan, Huaijiang;  Cheng, Xiaolan;  Ye, Juan;  Lu, Wuguang;  Hu, Chunping;  Sun, Handong;  Pu, Jianxin;  Cao, Peng
浏览  |  Adobe PDF(1370Kb)  |  收藏  |  浏览/下载：515/233  |  提交时间：2017/02/28
Eriocalyxin B, a Novel Autophagy Inducer, Exerts Anti-tumor Activity Through the Suppression of Akt/mTOR/p70S6K Signaling Pathway In breast Cancer 期刊论文
Biochemical Pharmacology, 2017, 卷号: 142, 页码: 58–70
作者:  Xunian Zhou;  Grace Gar-Lee Yue;  Andrew Man-Lok Chan;   Stephen Kwok-Wing Tsui;  Kwok-Pui Fung;   Handong Sun;  Jianxin Pu;  Clara Bik-San Lau
浏览  |  Adobe PDF(5871Kb)  |  收藏  |  浏览/下载：240/58  |  提交时间：2017/11/20
Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 50, 页码: 82820-82835
作者:  Zhou, Xunian;  Yue, Grace Gar-Lee;  Liu, Minghua;  Zuo, Zhili;  Lee, Julia Kin-Ming;  Li, Mingyue;  Tsui, Stephen Kwok-Wing;  Fung, Kwok-Pui;  Sun, Handong;  Pu, Jianxin;  Lau, Clara Bik-San
浏览  |  Adobe PDF(13632Kb)  |  收藏  |  浏览/下载：386/48  |  提交时间：2017/02/28
Eriocalyxin b  Angiogenesis  Vascular Endothelial Growth Factor (Vegf)  Vascular Endothelial Growth Factor Receptor 2(Vegfr-2)  Breast Cancer  
SJP-L-5, a novel small-molecule compound, inhibits HIV-1 infection by blocking viral DNA nuclear entry 期刊论文
BMC MICROBIOLOGY, 2015, 卷号: 15
作者:  Bai,Ru;  Zhang,Xing-Jie;  Li,Yan-Li;  Liu,Jing-Ping;  Zhang,Hong-Bin;  Xiao,Wei-Lie;  Pu,Jian-Xin;  Sun,Han-Dong;  Zheng,Yong-Tang;  Liu,Li-Xin
浏览  |  Adobe PDF(2540Kb)  |  收藏  |  浏览/下载：236/60  |  提交时间：2016/01/19
Hiv-1  Pre-integration Complex  Nuclear Entry  Capsid  Sjp-l-5  
Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2015, 卷号: 78, 期号: 1, 页码: 10-16
作者:  Yao, Ran;  Chen, Zhaoli;  Zhou, Chengcheng;  Luo, Mei;  Shi, Xuejiao;  Li, Jiagen;  Gao, Yibo;  Zhou, Fang;  Pu, Jianxin;  Sun, Handong;  He, Jie
浏览  |  Adobe PDF(6589Kb)  |  收藏  |  浏览/下载：345/63  |  提交时间：2015/06/29
Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer 期刊论文
BREAST CANCER RESEARCH, 2014, 卷号: 16, 期号: 4, 页码: 8220-8224
作者:  O'Leary, Patrick C.;  Terrile, Marta;  Bajor, Malgorzata;  Gaj, Pawel;  Hennessy, Bryan T.;  Mills, Gordon B.;  Zagozdzon, Agnieszka;  O'Connor, Darran P.;  Brennan, Donal J.;  Connor, Kate;  Li, Jane;  Gonzalez-Angulo, Ana Maria;  Sun, Han-Dong;  Pu, Jian-Xin;  Ponten, Fredrik;  Uhlen, Mathias;  Jirstrom, Karin;  Nowis, Dominika A.;  Crown, John P.;  Zagozdzon, Radoslaw;  Gallagher, William M.;  Zagozdzon,R (reprint author),UCD Sch Biomol & Biomed Sci,UCD Conway Inst,Canc Biol & Therapeut Lab,Dublin 4,Ireland.;  radoslaw.zagozdzon@wum.edu.pl;  william.gallagher@ucd.ie
浏览  |  Adobe PDF(2561Kb)  |  收藏  |  浏览/下载：232/71  |  提交时间：2015/01/20
Natural-products  Roots  Secretion  Norsesquiterpenoids  Norbisabolane  Pyrimidine