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Synthesis and biological evaluation of (20S,24R)-epoxy-dammarane-3 beta,12 beta,25-triol derivatives as alpha-glucosidase and PTP1B inhibitors 期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2022, 卷号: 31, 期号: 2, 页码: 350-367
作者:  Yang, Xiao-Tong;  Li, Tian-Ze;  Geng, Chang-An;  Liu, Pei;  Chen, Ji-Jun
浏览  |  Adobe PDF(1348Kb)  |  收藏  |  浏览/下载：17/5  |  提交时间：2024/04/30
(20S,24R)-epoxy-dammarane-3 beta,12 beta,25-triol  alpha-glucosidase inhibitors  PTP1B inhibitors  Enzyme kinetics  TYROSINE-PHOSPHATASE 1B  DIABETES-MELLITUS  EPIDEMIOLOGY  
Artematrolide A inhibited cervical cancer cell proliferation via ROS/ERK/mTOR pathway and metabolic shift 期刊论文
PHYTOMEDICINE, 2021, 卷号: 91, 页码: 153707
作者:  Zhang,Xin-Tian;  Hu,Jing;  Su,Li-Hua;  Geng,Chang-An;  Chen,Ji-Jun
浏览  |  Adobe PDF(6313Kb)  |  收藏  |  浏览/下载：97/29  |  提交时间：2022/04/02
Artemisia atrovirens  Cervical cancer  ERK pathway  Cell metabolism  ALKALINE-PHOSPHATASE  SIGNALING PATHWAY  DIFFERENTIATION  APOPTOSIS  ERK  MECHANISMS  
Diarylheptanoid-flavanone Hybrids as Multiple-target Antidiabetic Agents from Alpinia katsumadai 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2021, 卷号: 39, 期号: 11, 页码: 3051-3063
作者:  He,Xiao-Feng;  Chen,Ji-Jun;  Li,Tian-Ze;  Hu,Jing;  Huang,Xiao-Yan;  Zhang,Xue-Mei;  Guo,Yuan-Qiang;  Geng,Chang-An
浏览  |  Adobe PDF(2762Kb)  |  收藏  |  浏览/下载：130/56  |  提交时间：2022/04/02
Alpinia katsumadai  Katsumadainols B-1-B-15  Natural products  Structure elucidation  Biological activity  TYROSINE-PHOSPHATASE 1B  GLYCOGEN-PHOSPHORYLASE  ALPHA-GLUCOSIDASE  ABSOLUTE-CONFIGURATION  STRUCTURE ELUCIDATION  DUAL INHIBITION  SEEDS  CONSTITUENT  DERIVATIVES  CHALCONE  
Diarylheptanoid-chalcone hybrids with PTP1B and alpha-glucosidase dual inhibition from Alpinia katsumadai 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 108, 页码: 104683
作者:  He,Xiao-Feng;  Chen,Ji-Jun;  Li,Tian-Ze;  Hu,Jing;  Zhang,Xue-Mei;  Geng,Chang-An
Adobe PDF(2223Kb)  |  收藏  |  浏览/下载：124/51  |  提交时间：2022/04/02
Alpinia katsumadai  Katsumadainols A(1)-A(16)  PTP1B/TCPTP selective inhibitors  alpha-glucosidase inhibitors  Antidiabetic effects  THEORETICAL CALCULATION  ABSOLUTE-CONFIGURATION  SEEDS  BLEPHAROCALYXINS  ADDUCT  MOIETY  
Synthesis and anti-fibrotic effects of santamarin derivatives as cytotoxic agents against hepatic stellate cell line LX2 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 41, 页码: 127994
作者:  Wang,Jin-Ping;  Li,Tian-Ze;  Huang,Xiao-Yan;  Geng,Chang-An;  Shen,Cheng;  Sun,Jin-Jin;  Xue,Dong;  Chen,Ji-Jun
Adobe PDF(567Kb)  |  收藏  |  浏览/下载：81/26  |  提交时间：2022/04/02
Santamarin derivatives  Anti-fibrotic effects  HSC-LX2  Extracellular matrix  NF-KAPPA-B  SESQUITERPENE LACTONES  LIVER FIBROSIS  STRUCTURE REQUIREMENT  BAY LEAF  ACTIVATION  
ent-Labdane and ent-kaurane diterpenoids from Chelonopsis odontochila with alpha-glucosidase inhibitory activity 期刊论文
BIOORGANIC CHEMISTRY, 2020
作者:  Deng, Zhen-Tao;  Chen, Ji-Jun;  Geng, Chang-An
Adobe PDF(3607Kb)  |  收藏  |  浏览/下载：122/37  |  提交时间：2021/01/05
First total synthesis of rhuscholide A, glabralide B and denudalide 期刊论文
TETRAHEDRON LETTERS, 2019, 卷号: 60, 期号: 38, 页码: 4
作者:  Li, Tian-Ze;  Geng, Chang-An;  Chen, Ji-Jun
Adobe PDF(709Kb)  |  收藏  |  浏览/下载：249/45  |  提交时间：2019/11/07
Total synthesis  Rhuscholide A  Glabralide B  Denudalide  
Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis 期刊论文
PHYTOCHEMISTRY, 2019, 卷号: 164, 页码: 228-235
作者:  Yang, Tong-Hua;  Yan, De-Xiu;  Huang, Xiao-Yan;  Hou, Bo;  Ma, Yun-Bao;  Peng, Hua;  Zhang, Xue-Mei;  Chen, Ji-Jun;  Geng, Chang-An
Adobe PDF(2111Kb)  |  收藏  |  浏览/下载：257/27  |  提交时间：2019/09/10
Terminthia paniculata (Wall. ex G. Don) CY Wu & TL Ming  Anacardiaceae  Termipaniculatones A-F  Chalcone-flavonone heterodimers  Xanthine oxidase inhibitors  Anti-gout potency  
Antidiabetic Stilbenes from Peony Seeds with PTP1B, alpha-Glucosidase, and DPPIV Inhibitory Activities 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 24, 页码: 6765-6772
作者:  Zhang,Chen-Chen;  Geng,Chang-An;  Huang,Xiao-Yan;  Zhang,Xue-Mei;  Chen,Ji-Jun
Adobe PDF(3231Kb)  |  收藏  |  浏览/下载：103/38  |  提交时间：2020/04/02
Bioinformatics analysis of differentially expressed genes in hepatocellular carcinoma cells exposed to Swertiamarin 期刊论文
JOURNAL OF CANCER, 2019, 卷号: 10, 期号: 26, 页码: 6526-6534
作者:  Tang, Haoran;  Ke, Yang;  Ren, Zongfang;  Lei, Xuefen;  Xiao, Shufeng;  Bao, Tianhao;  Shi, Zhitian;  Zou, Renchao;  Wu, Tiangen;  Zhou, Jian;  Geng, Chang-An;  Wang, Lin;  Chen, Jijun
Adobe PDF(2228Kb)  |  收藏  |  浏览/下载：128/32  |  提交时间：2020/03/24
swertiamarin  microarray  HepG2 cells  hepatocellular cancer  Jun  Stat3