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First total synthesis of rhuscholide A, glabralide B and denudalide
Li, Tian-Ze1; Geng, Chang-An1; Chen, Ji-Jun1,2
Corresponding AuthorChen, Ji-Jun(chenjj@mail.kib.ac.cn)
2019-09-19
Source PublicationTETRAHEDRON LETTERS
ISSN0040-4039
Volume60Issue:38Pages:4
AbstractThe first total synthesis of rhuscholide A, a benzofuran lactone possessing anti-HIV-1 activity, had been accomplished in 14 linear steps with 10.6% overall yield. In this synthesis, base-mediated phenol ortho-alkylation and piperidine promoted aldol condensation were exploited as key steps. The synthesis was flexible and allowed for the convenient preparation of two analogous natural products glabralide B and denudalide. (C) 2019 Published by Elsevier Ltd.
KeywordTotal synthesis Rhuscholide A Glabralide B Denudalide
DOI10.1016/j.tetlet.2019.151059
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000488141200015
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/69493
Collection中国科学院昆明植物研究所
Corresponding AuthorChen, Ji-Jun
Affiliation1.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Tian-Ze,Geng, Chang-An,Chen, Ji-Jun. First total synthesis of rhuscholide A, glabralide B and denudalide[J]. TETRAHEDRON LETTERS,2019,60(38):4.
APA Li, Tian-Ze,Geng, Chang-An,&Chen, Ji-Jun.(2019).First total synthesis of rhuscholide A, glabralide B and denudalide.TETRAHEDRON LETTERS,60(38),4.
MLA Li, Tian-Ze,et al."First total synthesis of rhuscholide A, glabralide B and denudalide".TETRAHEDRON LETTERS 60.38(2019):4.
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