Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis
Yang, Tong-Hua1,2; Yan, De-Xiu1,2; Huang, Xiao-Yan1,2; Hou, Bo1,2,4; Ma, Yun-Bao1,2; Peng, Hua3; Zhang, Xue-Mei1,2; Chen, Ji-Jun1,2,4; Geng, Chang-An1,2
Corresponding AuthorGeng, Chang-An(gengchangan@mail.kib.ac.cn)
2019-08-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume164Pages:228-235
AbstractTerminthia paniculata (Sanyeqi) is widely used for treating inflammation and rheumatic arthritis in the folk areas of Yunnan province, China. Its total extract was first revealed with xanthine oxidase (XO) inhibitory activity in vitro and anti-hyperuricemic effect in vivo. Bioassay-guided separation on Fr. A5 yielded six chalcone-flavonone heterodimers, termipaniculatones A-F. Their structures were elucidated based on extensive spectroscopic analyses involving HRESIMS, 1D and 2D NMR, UV, IR and [alpha](D), and the absolute configuration of termipaniculatone F was verified by ECD calculation. Termipaniculatones A and E showed obvious XO inhibitory activity with IC50 values of 55.6 and 89.5 mu M, respectively, which took effects via a mix-type mode. A molecular modeling study revealed that termipaniculatone A was well located into the active site of XO by interacting with G1u802, Arg880, Thr1010 and Val1011 residues. Termipaniculatone A showed anti-hyperuricemic effects by decreasing serum uric acid levels and inhibiting XO activity in both serum and liver on potassium oxonate (PO)-induced hyperuricemia mice, and anti-inflammatory activity through alleviating paw swelling on monosodium urate (MSU)-induced mice, at the concentration of 20 mg/kg. This is the first time to reveal the anti-hyperuricemic and anti-acute gouty arthritis potency of T. paniculata and the characteristic biflavonoids as active constituents, which provides valuable information for searching new XO inhibitors from natural sources.
KeywordTerminthia paniculata (Wall. ex G. Don) CY Wu & TL Ming Anacardiaceae Termipaniculatones A-F Chalcone-flavonone heterodimers Xanthine oxidase inhibitors Anti-gout potency
DOI10.1016/j.phytochem.2019.05.019
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000475996800026
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/68257
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorGeng, Chang-An
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Yunnan, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yang, Tong-Hua,Yan, De-Xiu,Huang, Xiao-Yan,et al. Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis[J]. PHYTOCHEMISTRY,2019,164:228-235.
APA Yang, Tong-Hua.,Yan, De-Xiu.,Huang, Xiao-Yan.,Hou, Bo.,Ma, Yun-Bao.,...&Geng, Chang-An.(2019).Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis.PHYTOCHEMISTRY,164,228-235.
MLA Yang, Tong-Hua,et al."Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis".PHYTOCHEMISTRY 164(2019):228-235.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Tong-Hua]'s Articles
[Yan, De-Xiu]'s Articles
[Huang, Xiao-Yan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Tong-Hua]'s Articles
[Yan, De-Xiu]'s Articles
[Huang, Xiao-Yan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Tong-Hua]'s Articles
[Yan, De-Xiu]'s Articles
[Huang, Xiao-Yan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.