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Antidiabetic Stilbenes from Peony Seeds with PTP1B, alpha-Glucosidase, and DPPIV Inhibitory Activities
Zhang,Chen-Chen; Geng,Chang-An; Huang,Xiao-Yan; Zhang,Xue-Mei; Chen,Ji-Jun
2019
发表期刊JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
卷号67期号:24页码:6765-6772
摘要One unusual resveratrol tetramer, paeonilactiflorol (1), and 14 known compounds (2-15) were isolated from peony seeds (Paeonia lactiflora) under the guidance of bioassay. Paeonilactiflorol (1) was determined by extensive HRESIMS, UV, IR, 1D and 2D NMR spectroscopic analyses. Most of the stilbenes showed obvious inhibition on PTP1B and alpha-glucosidase, superior to the monoterpene glycosides. Especially, the stilbene tetramer (1) and trimer (8) exhibited high activity inhibiting both PTP1B with IC50 values of 27.23 and 27.81 mu M and alpha-glucosidase with IC50 values of 13.57 and 14.39 mu M. Two trans-dimers (4 and 5) also showed dipeptidyl peptidase-4 (DPPIV) inhibitory activity (55.35% and 61.26%, 500 mu M) in addition to PTP1B and alpha-glucosidase. Enzyme kinetic study indicated that the types of inhibition on PTP1B were noncompetitive for 3 and 5 and mixed for 8 and 10. Quantitative analysis suggested that the stilbene trimers 8 (23.17 +/- 0.36 mg/g) and 10 (15.24 +/- 0.25 mg/g) were the main contents in peony seeds and should be responsible for the antidiabetic effects. This investigation supports the therapeutic potential of peony seeds in the treatment of diabetes with stilbenes as the active constituents.
DOI10.1021/acs.jafc.9b01193
收录类别SCI
WOS记录号WOS:000472679000010
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/71113
专题中国科学院昆明植物研究所
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GB/T 7714
Zhang,Chen-Chen,Geng,Chang-An,Huang,Xiao-Yan,et al. Antidiabetic Stilbenes from Peony Seeds with PTP1B, alpha-Glucosidase, and DPPIV Inhibitory Activities[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(24):6765-6772.
APA Zhang,Chen-Chen,Geng,Chang-An,Huang,Xiao-Yan,Zhang,Xue-Mei,&Chen,Ji-Jun.(2019).Antidiabetic Stilbenes from Peony Seeds with PTP1B, alpha-Glucosidase, and DPPIV Inhibitory Activities.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(24),6765-6772.
MLA Zhang,Chen-Chen,et al."Antidiabetic Stilbenes from Peony Seeds with PTP1B, alpha-Glucosidase, and DPPIV Inhibitory Activities".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.24(2019):6765-6772.
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