Antidiabetic Stilbenes from Peony Seeds with PTP1B, alpha-Glucosidase, and DPPIV Inhibitory Activities

doi:10.1021/acs.jafc.9b01193

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	Antidiabetic Stilbenes from Peony Seeds with PTP1B, alpha-Glucosidase, and DPPIV Inhibitory Activities
	Zhang,Chen-Chen; Geng,Chang-An; Huang,Xiao-Yan; Zhang,Xue-Mei; Chen,Ji-Jun
	2019
Source Publication	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	0021-8561
Volume	67 Issue:24 Pages:6765-6772
Abstract	One unusual resveratrol tetramer, paeonilactiflorol (1), and 14 known compounds (2-15) were isolated from peony seeds (Paeonia lactiflora) under the guidance of bioassay. Paeonilactiflorol (1) was determined by extensive HRESIMS, UV, IR, 1D and 2D NMR spectroscopic analyses. Most of the stilbenes showed obvious inhibition on PTP1B and alpha-glucosidase, superior to the monoterpene glycosides. Especially, the stilbene tetramer (1) and trimer (8) exhibited high activity inhibiting both PTP1B with IC50 values of 27.23 and 27.81 mu M and alpha-glucosidase with IC50 values of 13.57 and 14.39 mu M. Two trans-dimers (4 and 5) also showed dipeptidyl peptidase-4 (DPPIV) inhibitory activity (55.35% and 61.26%, 500 mu M) in addition to PTP1B and alpha-glucosidase. Enzyme kinetic study indicated that the types of inhibition on PTP1B were noncompetitive for 3 and 5 and mixed for 8 and 10. Quantitative analysis suggested that the stilbene trimers 8 (23.17 +/- 0.36 mg/g) and 10 (15.24 +/- 0.25 mg/g) were the main contents in peony seeds and should be responsible for the antidiabetic effects. This investigation supports the therapeutic potential of peony seeds in the treatment of diabetes with stilbenes as the active constituents.
DOI	10.1021/acs.jafc.9b01193
Indexed By	SCI
WOS ID	WOS:000472679000010
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/71113
Collection	中国科学院昆明植物研究所
Recommended Citation GB/T 7714	Zhang,Chen-Chen,Geng,Chang-An,Huang,Xiao-Yan,et al. Antidiabetic Stilbenes from Peony Seeds with PTP1B, alpha-Glucosidase, and DPPIV Inhibitory Activities[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(24):6765-6772.
APA	Zhang,Chen-Chen,Geng,Chang-An,Huang,Xiao-Yan,Zhang,Xue-Mei,&Chen,Ji-Jun.(2019).Antidiabetic Stilbenes from Peony Seeds with PTP1B, alpha-Glucosidase, and DPPIV Inhibitory Activities.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(24),6765-6772.
MLA	Zhang,Chen-Chen,et al."Antidiabetic Stilbenes from Peony Seeds with PTP1B, alpha-Glucosidase, and DPPIV Inhibitory Activities".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.24(2019):6765-6772.

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