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A Novel bis-indole Alkaloid from the Flowers of Rauvolfia yunnanensis Tsiang and its Antihypertension Activity 期刊论文
LETTERS IN ORGANIC CHEMISTRY, 2020, 卷号: 17, 期号: 2, 页码: 96-100
作者:  Wang, Haibo;  Liu, Xikui
收藏  |  浏览/下载：132/0  |  提交时间：2020/03/18
Alkaloid  Bis-indole alkaloid  Rauvolfia yunnanensis  rauvolfia flowers  antihypertension  reserpine  
Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 93, 页码: 13
作者:  Zhou, Yeheng;  Sun, Wei;  Peng, Jiale;  Yan, Hui;  Zhang, Li;  Liu, Xingyong;  Zuo, Zhili
Adobe PDF(4739Kb)  |  收藏  |  浏览/下载：210/32  |  提交时间：2020/03/18
Acetylcholinesterase  Drug design  N-acylhydrazone  Dementia  Copper-chelating  N-Benzylpiperidine  
Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1 期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2019, 卷号: 32, 期号: 10, 页码: 1965-1976
作者:  Yang, Xiao-Nan;  Wang, Yi-Kun;  Zhu, Xu;  Xiao, Xue-Rong;  Dai, Man-Yun;  Zhang, Ting;  Qu, Yan;  Yang, Xiu-Wei;  Qin, Hong-Bo;  Gonzalez, Frank J.;  Li, Fei
浏览  |  Adobe PDF(9057Kb)  |  收藏  |  浏览/下载：229/47  |  提交时间：2020/03/26
The Protective Roles of PPAR alpha Activation in Triptolide-Induced Liver Injury 期刊论文
TOXICOLOGICAL SCIENCES, 2019, 卷号: 171, 期号: 1, 页码: 1-12
作者:  Hu, Dan-Dan;  Zhao, Qi;  Cheng, Yan;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Qu, Yan;  Li, Xian;  Tang, Ying-Mei;  Bao, Wei-Min;  Yang, Jin-Hui;  Jiang, Tao;  Hu, Jia-Peng;  Gonzalez, Frank J.;  Li, Fei
浏览  |  Adobe PDF(1740Kb)  |  收藏  |  浏览/下载：232/31  |  提交时间：2020/03/26
liver injury  metabolomics  PPAR alpha  acylcarnitines  
Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice 期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2019, 卷号: 131, 页码: 8
作者:  Yang, Meilian;  Wu, Zihuan;  Wang, Yudan;  Kai, Guoyin;  Njateng, Guy Sedar Singor;  Cai, Shengbao;  Cao, Jianxin;  Cheng, Guiguang
浏览  |  Adobe PDF(1779Kb)  |  收藏  |  浏览/下载：200/53  |  提交时间：2019/10/28
Epigynum auritum  Acute and subacute oral toxicities  Hematology  Histopathology  Serum biochemistry analysis  
Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 29, 页码: 8243-8252
作者:  Wang, Yi-Kun;  Yang, Xiao-Nan;  Zhu, Xu;  Xiao, Xue-Rong;  Yang, Xiu-Wei;  Qin, Hong-Bo;  Gonzalez, Frank J.;  Li, Fei
浏览  |  Adobe PDF(3136Kb)  |  收藏  |  浏览/下载：188/61  |  提交时间：2019/09/10
elemicin  l'-hydroxyelemicin  metabolic activation  cytotoxicity  
Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2019, 卷号: 176, 期号: 13, 页码: 2162-2178
作者:  Zhao, Qi;  Zhang, Ting;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Wang, Yan;  Gonzalez, Frank J.;  Li, Fei
浏览  |  Adobe PDF(3915Kb)  |  收藏  |  浏览/下载：246/42  |  提交时间：2019/07/29
A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice 期刊论文
XENOBIOTICA, 2019, 卷号: 49, 期号: 6, 页码: 655-670
作者:  Wang, Yi-Kun;  Yang, Xiao-Nan;  Liang, Wei-Qing;  Xiao, Yao;  Zhao, Qi;  Xiao, Xue-Rong;  Gonzalez, Frank J.;  Li, Fei
浏览  |  Adobe PDF(1101Kb)  |  收藏  |  浏览/下载：273/113  |  提交时间：2019/07/29
Pazopanib  hepatotoxicity  metabolomics  oxidative stress  ultra-performance liquid chromatography-electrospray ion source-quadrupole  time-of-flight mass spectrometer (UPLC-ESI-QTOFMS)  
The sources and mechanisms of bioactive ingredients in coffee 期刊论文
FOOD & FUNCTION, 2019, 卷号: 10, 期号: 6, 页码: 3113-3126
作者:  Hu, G. L.;  Wang, X.;  Zhang, L.;  Qiu, M. H.
浏览  |  Adobe PDF(2231Kb)  |  收藏  |  浏览/下载：211/58  |  提交时间：2019/09/10
Metabolic Activation of Myristicin and Its Role in Cellular Toxicity 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 15, 页码: 4328-4336
作者:  Zhu, Xu;  Wang, Yi-Kun;  Yang, Xiao-Nan;  Xiao, Xue-Rong;  Zhang, Ting;  Yang, Xiu-Wei;  Qin, Hong-Bo;  Li, Fei
浏览  |  Adobe PDF(4316Kb)  |  收藏  |  浏览/下载：239/44  |  提交时间：2019/05/24
myristicin  1 '-hydroxymyristicin  metabolic activation  metabolomics