| Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice | |
| Yang, Meilian1; Wu, Zihuan1; Wang, Yudan2; Kai, Guoyin3; Njateng, Guy Sedar Singor4; Cai, Shengbao1; Cao, Jianxin1; Cheng, Guiguang1 | |
| Corresponding Author | Cao, Jianxin(jxcao321@hotmail.com) ; Cheng, Guiguang(chengguiguang@163.com) |
| 2019-09-01 | |
| Source Publication | FOOD AND CHEMICAL TOXICOLOGY
 |
| ISSN | 0278-6915 |
| Volume | 131Pages:8 |
| Abstract | Acute and subacute toxicities of the ethanol extract from Epigynum auritum (EAE) wereperformed by oral administration in pathogen-free mice. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days, while subacute toxicity test was conducted by daily oral administration of EAE at doses of 312, 625, 1250, and 2500 mg/kg for 28 days. Acute toxicity study showed that LD50 of EAE was over 5000 mg/kg. The results of subacute toxicity showed no significant adverse effect of EAE at 312 mg/kg. Moreover, EAE exhibited toxicities to liver, spleen and kidney in mice determined by hematological, serum biochemical and histological analyses during daily oral administration of 1250 mg/kg and 2500 mg/kg EAE. The results revealed that the dose of EAE lower than 625 mg/kg can be regarded as safe. |
| Keyword | Epigynum auritum Acute and subacute oral toxicities Hematology Histopathology Serum biochemistry analysis |
| DOI | 10.1016/j.fct.2019.05.042 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000482246600043 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/68815 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Cao, Jianxin; Cheng, Guiguang |
| Affiliation | 1.Kunming Univ Sci & Technol, Yunnan Inst Food Safety, Kunming 650500, Yunnan, Peoples R China 2.Yunnan Minzu Univ, Engn Res Ctr Biopolymer Funct Mat Yunnan, Kunming 650500, Yunnan, Peoples R China 3.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Yang, Meilian,Wu, Zihuan,Wang, Yudan,et al. Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice[J]. FOOD AND CHEMICAL TOXICOLOGY,2019,131:8. |
| APA | Yang, Meilian.,Wu, Zihuan.,Wang, Yudan.,Kai, Guoyin.,Njateng, Guy Sedar Singor.,...&Cheng, Guiguang.(2019).Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice.FOOD AND CHEMICAL TOXICOLOGY,131,8. |
| MLA | Yang, Meilian,et al."Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice".FOOD AND CHEMICAL TOXICOLOGY 131(2019):8. |
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| File Name/Size | DocType | Version | Access | License | ||
| Yang-2019-Acute and （1779KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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