Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice
Yang, Meilian1; Wu, Zihuan1; Wang, Yudan2; Kai, Guoyin3; Njateng, Guy Sedar Singor4; Cai, Shengbao1; Cao, Jianxin1; Cheng, Guiguang1
Corresponding AuthorCao, Jianxin(jxcao321@hotmail.com) ; Cheng, Guiguang(chengguiguang@163.com)
2019-09-01
Source PublicationFOOD AND CHEMICAL TOXICOLOGY
ISSN0278-6915
Volume131Pages:8
AbstractAcute and subacute toxicities of the ethanol extract from Epigynum auritum (EAE) wereperformed by oral administration in pathogen-free mice. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days, while subacute toxicity test was conducted by daily oral administration of EAE at doses of 312, 625, 1250, and 2500 mg/kg for 28 days. Acute toxicity study showed that LD50 of EAE was over 5000 mg/kg. The results of subacute toxicity showed no significant adverse effect of EAE at 312 mg/kg. Moreover, EAE exhibited toxicities to liver, spleen and kidney in mice determined by hematological, serum biochemical and histological analyses during daily oral administration of 1250 mg/kg and 2500 mg/kg EAE. The results revealed that the dose of EAE lower than 625 mg/kg can be regarded as safe.
KeywordEpigynum auritum Acute and subacute oral toxicities Hematology Histopathology Serum biochemistry analysis
DOI10.1016/j.fct.2019.05.042
Indexed BySCI
Language英语
WOS IDWOS:000482246600043
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/68815
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorCao, Jianxin; Cheng, Guiguang
Affiliation1.Kunming Univ Sci & Technol, Yunnan Inst Food Safety, Kunming 650500, Yunnan, Peoples R China
2.Yunnan Minzu Univ, Engn Res Ctr Biopolymer Funct Mat Yunnan, Kunming 650500, Yunnan, Peoples R China
3.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Yang, Meilian,Wu, Zihuan,Wang, Yudan,et al. Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice[J]. FOOD AND CHEMICAL TOXICOLOGY,2019,131:8.
APA Yang, Meilian.,Wu, Zihuan.,Wang, Yudan.,Kai, Guoyin.,Njateng, Guy Sedar Singor.,...&Cheng, Guiguang.(2019).Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice.FOOD AND CHEMICAL TOXICOLOGY,131,8.
MLA Yang, Meilian,et al."Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice".FOOD AND CHEMICAL TOXICOLOGY 131(2019):8.
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