Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice

doi:10.1016/j.fct.2019.05.042

	Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice
	Yang, Meilian 1; Wu, Zihuan 1; Wang, Yudan 2; Kai, Guoyin 3; Njateng, Guy Sedar Singor 4; Cai, Shengbao 1; Cao, Jianxin 1; Cheng, Guiguang 1
通讯作者	Cao, Jianxin(jxcao321@hotmail.com) ; Cheng, Guiguang(chengguiguang@163.com)
	2019-09-01
发表期刊	FOOD AND CHEMICAL TOXICOLOGY
ISSN	0278-6915
卷号	131 页码:8
摘要	Acute and subacute toxicities of the ethanol extract from Epigynum auritum (EAE) wereperformed by oral administration in pathogen-free mice. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days, while subacute toxicity test was conducted by daily oral administration of EAE at doses of 312, 625, 1250, and 2500 mg/kg for 28 days. Acute toxicity study showed that LD50 of EAE was over 5000 mg/kg. The results of subacute toxicity showed no significant adverse effect of EAE at 312 mg/kg. Moreover, EAE exhibited toxicities to liver, spleen and kidney in mice determined by hematological, serum biochemical and histological analyses during daily oral administration of 1250 mg/kg and 2500 mg/kg EAE. The results revealed that the dose of EAE lower than 625 mg/kg can be regarded as safe.
关键词	Epigynum auritum Acute and subacute oral toxicities Hematology Histopathology Serum biochemistry analysis
DOI	10.1016/j.fct.2019.05.042
收录类别	SCI
语种	英语
WOS记录号	WOS:000482246600043
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/68815
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Cao, Jianxin; Cheng, Guiguang
作者单位	1.Kunming Univ Sci & Technol, Yunnan Inst Food Safety, Kunming 650500, Yunnan, Peoples R China 2.Yunnan Minzu Univ, Engn Res Ctr Biopolymer Funct Mat Yunnan, Kunming 650500, Yunnan, Peoples R China 3.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yang, Meilian,Wu, Zihuan,Wang, Yudan,et al. Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice[J]. FOOD AND CHEMICAL TOXICOLOGY,2019,131:8.
APA	Yang, Meilian.,Wu, Zihuan.,Wang, Yudan.,Kai, Guoyin.,Njateng, Guy Sedar Singor.,...&Cheng, Guiguang.(2019).Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice.FOOD AND CHEMICAL TOXICOLOGY,131,8.
MLA	Yang, Meilian,et al."Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice".FOOD AND CHEMICAL TOXICOLOGY 131(2019):8.

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