A Novel bis-indole Alkaloid from the Flowers of Rauvolfia yunnanensis Tsiang and its Antihypertension Activity

doi:10.2174/1570178616666190126153703

	A Novel bis-indole Alkaloid from the Flowers of Rauvolfia yunnanensis Tsiang and its Antihypertension Activity
	Wang, Haibo 1,2,3; Liu, Xikui 1
通讯作者	Wang, Haibo(wanghb616@163.com)
	2020
发表期刊	LETTERS IN ORGANIC CHEMISTRY
ISSN	1570-1786
卷号	17 期号:2 页码:96-100
摘要	A novel bis-indole alkaloid was isolated from the flowers of Rauvolfia Yunnanensis Tsiang. Its structure was elucidated as 10,11'- dimethoxy-11,10'-bis-[N(a)-methyl deacetyldeformyl- 1,2-dihydro alcuammiline(2 beta)] (1) on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as IIRESI-MS and comparison with data from the literature. The bis-indole alkaloid displayed more potent antihypertension activity and much lower hepatotoxicity in vivo than Reserpine.
关键词	Alkaloid Bis-indole alkaloid Rauvolfia yunnanensis rauvolfia flowers antihypertension reserpine
DOI	10.2174/1570178616666190126153703
收录类别	SCI ; SCI
语种	英语
WOS记录号	WOS:000506001100003
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/70571
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Wang, Haibo
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Zhejiang Hongyuan Pharmaceut Co Ltd, Linhai 317016, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Wang, Haibo,Liu, Xikui. A Novel bis-indole Alkaloid from the Flowers of Rauvolfia yunnanensis Tsiang and its Antihypertension Activity[J]. LETTERS IN ORGANIC CHEMISTRY,2020,17(2):96-100.
APA	Wang, Haibo,&Liu, Xikui.(2020).A Novel bis-indole Alkaloid from the Flowers of Rauvolfia yunnanensis Tsiang and its Antihypertension Activity.LETTERS IN ORGANIC CHEMISTRY,17(2),96-100.
MLA	Wang, Haibo,et al."A Novel bis-indole Alkaloid from the Flowers of Rauvolfia yunnanensis Tsiang and its Antihypertension Activity".LETTERS IN ORGANIC CHEMISTRY 17.2(2020):96-100.