A Novel bis-indole Alkaloid from the Flowers of Rauvolfia yunnanensis Tsiang and its Antihypertension Activity
Wang, Haibo1,2,3; Liu, Xikui1
Corresponding AuthorWang, Haibo(wanghb616@163.com)
2020
Source PublicationLETTERS IN ORGANIC CHEMISTRY
ISSN1570-1786
Volume17Issue:2Pages:96-100
AbstractA novel bis-indole alkaloid was isolated from the flowers of Rauvolfia Yunnanensis Tsiang. Its structure was elucidated as 10,11'- dimethoxy-11,10'-bis-[N(a)-methyl deacetyldeformyl- 1,2-dihydro alcuammiline(2 beta)] (1) on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as IIRESI-MS and comparison with data from the literature. The bis-indole alkaloid displayed more potent antihypertension activity and much lower hepatotoxicity in vivo than Reserpine.
KeywordAlkaloid Bis-indole alkaloid Rauvolfia yunnanensis rauvolfia flowers antihypertension reserpine
DOI10.2174/1570178616666190126153703
Indexed BySCI ; SCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000506001100003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/70571
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorWang, Haibo
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Zhejiang Hongyuan Pharmaceut Co Ltd, Linhai 317016, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Wang, Haibo,Liu, Xikui. A Novel bis-indole Alkaloid from the Flowers of Rauvolfia yunnanensis Tsiang and its Antihypertension Activity[J]. LETTERS IN ORGANIC CHEMISTRY,2020,17(2):96-100.
APA Wang, Haibo,&Liu, Xikui.(2020).A Novel bis-indole Alkaloid from the Flowers of Rauvolfia yunnanensis Tsiang and its Antihypertension Activity.LETTERS IN ORGANIC CHEMISTRY,17(2),96-100.
MLA Wang, Haibo,et al."A Novel bis-indole Alkaloid from the Flowers of Rauvolfia yunnanensis Tsiang and its Antihypertension Activity".LETTERS IN ORGANIC CHEMISTRY 17.2(2020):96-100.
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