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Pharmacological characterizationof tachykinin tetrabranched derivatives 期刊论文
出版物, 3111, 期号: 0, 页码: 1-36
作者:  Chiara Ruzza;  Anna Rizzi;  Davide Malfacini;  Maria Camilla Cerlesi;  Federica Ferrari;  Erika Marzola;  Caterina Ambrosio;  Cristina Gro;  Salvadori Severo;  Tommaso Costa;  Girolamo Calo;  Remo Guerrini
Adobe PDF(1277Kb)  |  收藏  |  浏览/下载：199/1  |  提交时间：2017/07/24
Tachykinins  Substance p  Pwt2-sp  Nk1 Receptor  Calcium Mobilization  Bioluminescence Resonance Energy Transfer  Guinea Pig Ileum  Rat Urinary Bladder  Nociceptive Behaviour Induced By Spinal Substance p  Mice  
Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii 期刊论文
PHYTOMEDICINE, 2023, 卷号: 121, 页码: 155054
作者:  Dai,Manyun;  Peng,Wan;  Lin,Lisha;  Wu,Zhanxuan;  Zhang,Ting;  Zhao,Qi;  Cheng,Yan;  Lin,Qiuxia;  Zhang,Binbin;  Liu,Aiming;  Rao,Qianru;  Huang,Jianfeng;  Zhao,Jinhua;  Gonzalez,Frank J.;  Li,Fei
浏览  |  Adobe PDF(17974Kb)  |  收藏  |  浏览/下载：69/19  |  提交时间：2024/07/17
Intestinal bleeding  Triptolide  Celastrol  Intestinal FXR  Tripterygium wilfordii  FARNESOID-X-RECEPTOR  BACTERIAL TRANSLOCATION  ACTIVATION  INFLAMMATION  DYSFUNCTION  TRIPTOLIDE  MICROBIOTA  PREVENTS  OBESITY  MICE  
Metabolomics Reveals Gut Microbiota Contribute to PPARα Deficiency-Induced Alcoholic Liver Injury 期刊论文
JOURNAL OF PROTEOME RESEARCH, 2023, 卷号: 22, 期号: 7, 页码: 2327-2338
作者:  Zhang,Ting;  Bao,Lijuan;  Zhao,Qi;  Wu,Zhanxuan E. E.;  Dai,Manyun;  Rao,Qianru;  Li,Fei
浏览  |  Adobe PDF(9616Kb)  |  收藏  |  浏览/下载：48/11  |  提交时间：2024/07/10
metabolomics  alcohol-induced liver injury  gut microbiota  PPAR & alpha  AROMATIC-AMINO-ACIDS  LIPID-METABOLISM  FED MICE  MODULATION  DISEASE  AXIS  OLEOYLETHANOLAMIDE  AGONIST  OBESITY  DEATH  
Metabolomics Reveals Gut Microbiota Contribute to PPAR & alpha; Deficiency-Induced Alcoholic Liver Injury 期刊论文
JOURNAL OF PROTEOME RESEARCH, 2023
作者:  Zhang,Ting;  Bao,Lijuan;  Zhao,Qi;  Wu,Zhanxuan E. E.;  Dai,Manyun;  Rao,Qianru;  Li,Fei
浏览  |  Adobe PDF(9616Kb)  |  收藏  |  浏览/下载：55/15  |  提交时间：2024/07/10
metabolomics  alcohol-induced liver injury  gut microbiota  PPAR & alpha  AROMATIC-AMINO-ACIDS  LIPID-METABOLISM  FED MICE  MODULATION  DISEASE  AXIS  OLEOYLETHANOLAMIDE  AGONIST  OBESITY  DEATH  
Quinoline derivatives and macamides from Maca (Lepidium meyenii) 期刊论文
PHYTOCHEMISTRY LETTERS, 2023, 卷号: 57, 页码: 62-66
作者:  Zang,Zhen;  Wang,Li;  Lei,Ze;  Yang,Fumei;  Li,Xiaonian;  Sun,Qianyun;  Zhao,Yong
浏览  |  Adobe PDF(563Kb)  |  收藏  |  浏览/下载：36/9  |  提交时间：2024/07/22
Lepidium meyenii  Quinolines  Macamides  Inhibitory activity  CONSTITUENTS  MICE  
ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 22, 页码: e2220148120
作者:  Zhou,Gui-Feng;  Tang,Jing;  Ma,Yuan-Lin;  Fu,Xian;  Liu,Jun-Yan;  Yang,Ren-Zhi;  Zhang,Hong-Sheng;  Cai,Xiang-Hai;  Wang,Jing-Wen;  Xie,Xiao-Yong;  Song,Li;  Luo,Biao;  Chen,Jian;  Chen,Long;  Deng,Xiao-Juan;  Chen,Guo-Jun
浏览  |  Adobe PDF(6685Kb)  |  收藏  |  浏览/下载：112/18  |  提交时间：2024/05/09
conophylline  ARL6IP1  5'UTR  FXR1  BACE1 translation  AMYLOID PRECURSOR PROTEIN  A-BETA  TRANSGENIC MICE  MOUSE MODEL  NEURODEGENERATION  EXPRESSION  REDUCTION  MEMBRANE  MEMORY  ER  
Novel PORCN inhibitor WHN-88 targets Wnt/?-catenin pathway and prevents the growth of Wnt-driven cancers 期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2023, 卷号: 945, 页码: 175628
作者:  Yang,Qihong;  Qin,Tong;  An,Tao;  Wu,Hongna;  Xu,Gang;  Xiang,Jin;  Lei,Kangfan;  Zhang,Shaohua;  Xia,Jie;  Su,Guifeng;  Wang,Dan;  Xue,Minggao;  Kong,Lingmei;  Zhang,Wenxuan;  Wu,Song;  Li,Yan
浏览  |  Adobe PDF(7197Kb)  |  收藏  |  浏览/下载：37/10  |  提交时间：2024/07/30
PORCN inhibitor  WHN-88  Palmitoylation  Wnt-driven cancers  SIGNALING PATHWAY  PORCUPINE  STEM  GENE  ACYLTRANSFERASE  MUTATIONS  POLARITY  PROTEIN  RNF43  MICE  
Methanolic extract of Cariniana rubra Gardner ex Miers stem bark negatively regulate the leukocyte migration and TNF-alpha and up-regulate the annexin-A1 expression 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2021, 卷号: 270, 页码: 113778
作者:  Paulino Brandao Silva,Donata Norman;  Adriana,Flach;  de Oliveira Martins,Domingos Tabajara;  Borges,Quessi Irias;  Nunes Lindote,Marcus Vitor;  Ramalho Zoratti,Marco Tulio;  de Oliveira,Ruberlei Godinho;  Vieira Torquato,Heron Fernandes;  Gazoni,Vanessa Fatima;  Alves da Costa,Luiz Antonio Mendonca;  Alexandre de Souza,Edineide Cristina;  Araujo da Silva,Felipe Moura;  Arunachalam,Karuppusamy;  Damazo,Amilcar Sabino
收藏  |  浏览/下载：83/0  |  提交时间：2022/04/02
Cariniana rubra, anti-inflammatory  Air pouch  TNF-alpha  Annexin A1  Gallic acid  Terpenes  Mice  GENE-EXPRESSION  INFLAMMATION  
FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 105338
作者:  Peng,Xing-Rong;  Wang,Qian;  Wang,Hui-Rong;  Hu,Kun;  Xiong,Wen-Yong;  Qiu,Ming-Hua
浏览  |  Adobe PDF(7004Kb)  |  收藏  |  浏览/下载：142/28  |  提交时间：2022/04/02
Ganoderma applanatum  Meroterpenoid dimers  Molecular docking  Anti-lipogenesis  FPR2-based inflammation  INDUCED INSULIN-RESISTANCE  ADIPOCYTE DIFFERENTIATION  OBESITY  INFLAMMATION  DEFICIENCY  MACROPHAGES  ACTIVATION  EXPRESSION  LIGAND  MICE  
PPAR alpha activation protects against cholestatic liver injury 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 页码: 9967
作者:  Zhao, Qi;  Yang, Rui;  Wang, Jing;  Hu, Dan-Dan;  Li, Fei
浏览  |  Adobe PDF(7693Kb)  |  收藏  |  浏览/下载：287/68  |  提交时间：2017/10/23
Primary Biliary-cirrhosis  Bile-acid Homeostasis  Receptor-alpha  Ursodeoxycholic Acid  Cholesterol 7-alpha-hydroxylase  Beta-oxidation  Fenofibrate  Therapy  Mice  Hepatotoxicity