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Identification of 3H-benzo[b] [1,4] diazepine derivatives as PPARα agonists by in silico studies and biochemical evaluation 期刊论文
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2023, 页码: 2256867
作者:  Li,Yue;  Lv,Mengjia;  Shen,Meiling;  Gu,Xi;  Zhang,Li;  Liu,Xingyong;  Chen,Jing;  Gong,Likun;  Zuo,Zhili
浏览  |  Adobe PDF(3338Kb)  |  收藏  |  浏览/下载：15/1  |  提交时间：2024/07/31
NAFLD  PPAR alpha agonist  virtual screening  biochemical evaluation  FATTY-ACID OXIDATION  GROMACS  
三尖杉属植物生物碱成分研究和活性酯碱资源评价 学位论文
: 中国科学院大学, 2022
作者:  余光兴
Adobe PDF(2195Kb)  |  收藏  |  浏览/下载：51/0  |  提交时间：2024/05/14
三尖杉属,种子,三尖杉生物碱,分离鉴定,酯碱资源评价  Cephalotaxus,Seeds,Cephalotaxine alkaloids,Isolation and identification,Ester alkaloids resources evaluation  
An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 105317
作者:  Munikishore,Rachakunta;  Wang,Liang-Liang;  Zhang,Shuqun;  Zhao,Qin-Shi;  Zuo,Zhili
Adobe PDF(523Kb)  |  收藏  |  浏览/下载：104/29  |  提交时间：2022/04/02
Cathepsin L  small-molecule inhibitor  gram-scale synthesis  KGP94  cancer  FUNCTIONALIZED BENZOPHENONE  BIOLOGICAL EVALUATION  TUMOR PROGRESSION  CELL INVASION  EXPRESSION  ANALOGS  SUPPRESSION  DERIVATIVES  ACID  
Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 104767
作者:  Guo,Sheng;  Xie,Hang;  Lei,Yu;  Liu,Bin;  Zhang,Li;  Xu,Yechun;  Zuo,Zhili
Adobe PDF(3181Kb)  |  收藏  |  浏览/下载：130/38  |  提交时间：2022/04/02
SARS-CoV-2  Main protease  Virtual screening  Biochemical evaluation  
An Approach for the Synthesis of Pyrazolo[1,5-a]pyrimidines via Cu(II)-Catalyzed [3+3] Annulation of Saturated Ketones with Aminopyrazoles 期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 86, 期号: 18, 页码: 12762-12771
作者:  Ren,Jian;  Ding,Shihua;  Li,Xiaonian;  Bi,Ran;  Zhao,Qinshi
Adobe PDF(1469Kb)  |  收藏  |  浏览/下载：126/29  |  提交时间：2022/04/02
BIOLOGICAL EVALUATION  REGIOSELECTIVE SYNTHESIS  CASCADE REACTIONS  FUNCTIONALIZATION  DEHYDROGENATION  DISCOVERY  POTENT  BOND  SAR  
Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 203, 页码: 114200
作者:  Zhou,Zi-Meng;  Yan,Dong-Mei;  Wang,Yi-Kun;  Zhang,Ting;  Xiao,Xue-Rong;  Dai,Man-Yun;  Zhang,Shou-Wen;  Liu,Hong-Ning;  Li,Fei
收藏  |  浏览/下载：84/0  |  提交时间：2022/04/02
Raspberry  Q-markers  Quality evaluation  UPLC-ESI-QTOF-MS  COMPONENTS  ACTIVATION  PATHWAY  FRUITS  
Synthesis and biological evaluation of novel 3-benzylcoumarin-imidazolium salts 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 4, 页码: 6
作者:  Wang, Xue-Quan;  Chen, Xue-Bing;  Ye, Ping-Ting;  Yang, Zhi-Xin;  Bai, Meng-Jiao;  Duan, Su-Yue;  Li, Yan;  Yang, Xiao-Dong
收藏  |  浏览/下载：243/0  |  提交时间：2020/03/18
3-Benzylcoumarin  Imidazolium salts  Biological evaluation  Cytotoxic activity  Structure-activity relationships  
Discovery of a potent and selective adenylyl cyclase type 8 agonist by docking-based virtual screening 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 2, 页码: 7
作者:  Weng, Zhiying;  Xu, Guowei;  Chen, Dingyuan;  Yang, Yaqing;  Song, Gao;  Shen, Wen;  Zhang, Shuqun;  Wang, LiangLiang;  Yang, Weimin;  Zuo, Zhili
收藏  |  浏览/下载：208/0  |  提交时间：2020/03/18
Adenylyl cyclases  Homology modeling  Consensus scoring  Molecular dynamics simulation  Virtual screening  Biological evaluation  
Pharmacokinetics and safety evaluation in healthy Chinese volunteers of alkaloids from leaf of Alstonia scholaris: A multiple doses phase I clinical trial 期刊论文
PHYTOMEDICINE, 2019, 卷号: 61, 页码: 13
作者:  Li, Rui;  Zi, Ming-Jie;  Gou, Zhong-Ping;  Zhao, Yun-Li;  Zhang, Wan-Tong;  Lu, Fang;  Cao, Wei-Yi;  Zhao, Ying-Pan;  Li, Qing-Na;  Zhao, Yang;  Wang, Shu-Ge;  Gao, Hong-Yang;  Sun, Ming-Yue;  Luo, Xiao-Dong;  Xiong, Zhi-Li;  Gao, Rui
浏览  |  Adobe PDF(3744Kb)  |  收藏  |  浏览/下载：277/81  |  提交时间：2020/03/17
Capsule of alkaloids from leaf of A. scholaris (CALAS)  Pharmacokinetics  Safety evaluation  Drug re-excitation research  
Chemical Composition and Antioxidant Activity of Tuber indicum from Different Geographical Regions of China 期刊论文
CHEMISTRY & BIODIVERSITY, 2019, 卷号: 16, 期号: 3, 页码: 12
作者:  Li, Jia-Mei;  Liang, Han-Qiao;  Qiao, Peng;  Su, Kai-Mei;  Liu, Pei-Gui;  Guo, Shun-Xing;  Chen, Juan
浏览  |  Adobe PDF(647Kb)  |  收藏  |  浏览/下载：295/118  |  提交时间：2019/07/29
Tuber indicum  Chinese black truffles  polysaccharides  radical-scavenging activity  quality evaluation  antioxidants