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Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii 期刊论文
PHYTOMEDICINE, 2023, 卷号: 121, 页码: 155054
作者:  Dai,Manyun;  Peng,Wan;  Lin,Lisha;  Wu,Zhanxuan;  Zhang,Ting;  Zhao,Qi;  Cheng,Yan;  Lin,Qiuxia;  Zhang,Binbin;  Liu,Aiming;  Rao,Qianru;  Huang,Jianfeng;  Zhao,Jinhua;  Gonzalez,Frank J.;  Li,Fei
浏览  |  Adobe PDF(17974Kb)  |  收藏  |  浏览/下载:69/19  |  提交时间:2024/07/17
Intestinal bleeding  Triptolide  Celastrol  Intestinal FXR  Tripterygium wilfordii  FARNESOID-X-RECEPTOR  BACTERIAL TRANSLOCATION  ACTIVATION  INFLAMMATION  DYSFUNCTION  TRIPTOLIDE  MICROBIOTA  PREVENTS  OBESITY  MICE  
High throughput-screening of native herbal compounds identifies taccaoside A as a cytotoxic compound that mediates RAS signaling in cancer stem cells 期刊论文
PHYTOMEDICINE, 2023, 卷号: 108, 页码: 154492
作者:  Yang,Dong;  Dai,Zhi;  Zhu,Peifeng;  Wang,Gan;  Sun,Bin;  Li,Shirong;  Hao,Junjun;  Wang,Yifen;  Liu,Yaping;  Yu,Shuaishuai;  Lai,Ren;  Luo,Xiao-Dong;  Zhao,Xudong
浏览  |  Adobe PDF(6987Kb)  |  收藏  |  浏览/下载:72/11  |  提交时间:2024/07/17
Natural product  Furostanol saponin  Taccaoside A  Cancer stem cell  RAS  STEROIDAL SAPONINS  NATURAL-PRODUCTS  PI3K/AKT  PROLIFERATION  MAINTENANCE  STATISTICS  MAPK/ERK  
Trigonochinene E promotes lysosomal biogenesis and enhances autophagy via TFEB/TFE3 in human degenerative NP cells against oxidative stress 期刊论文
PHYTOMEDICINE, 2023, 卷号: 112, 页码: 154720
作者:  Niu,Zhenpeng;  Tang,Guihua;  Wang,Xuenan;  Yang,Xu;  Zhao,Yueqin;  Wang,Yinyuan;  Liu,Qin;  Zhang,Fan;  Zhao,Yuhan;  Ding,Xiao;  Hao,Xiaojiang
浏览  |  Adobe PDF(11543Kb)  |  收藏  |  浏览/下载:57/12  |  提交时间:2024/07/17
Lysosomal biogenesis  Autophagy  TFEB  TFE3  ER stress  IVDD  STAT3  TFE3  
Rubiginosin B selectively inhibits Treg cell differentiation and enhances anti-tumor immune responses by targeting calcineurin-NFAT signaling pathway 期刊论文
PHYTOMEDICINE, 2023, 卷号: 116, 页码: 154898
作者:  Geng,Chang-An;  Chen,Feng-Yang;  Zheng,Jing-Bin;  Liao,Ping;  Li,Tian-Ze;  Zhang,Xue-Mei;  Chen,Xin;  Chen,Ji-Jun
浏览  |  Adobe PDF(5670Kb)  |  收藏  |  浏览/下载:69/14  |  提交时间:2024/07/17
Rubiginosin B (RGB)  CD4(+)Foxp3(+) regulatory T cells (Tregs)  Calcineurin  Nuclear factor of activated T cells (NFAT)  Tumor microenvironment  Rhododendron brachypodum  REGULATORY T-CELLS  RHODODENDRON  IMMUNOSUPPRESSION  DERIVATIVES  INDUCTION  EXPANSION  RAPAMYCIN  
Pharmacological investigation of indole alkaloids from Alstonia scholaris against chronic glomerulonephritis 期刊论文
PHYTOMEDICINE, 2023, 卷号: 118, 页码: 154958
作者:  Guo,Rui;  Shang,Jian-Hua;  Ye,Rui-Han;  Zhao,Yun-Li;  Luo,Xiao-Dong
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Alstonia scholaris  Indole alkaloids  Chronic glomerulonephritis  Network pharmacology  PI3K-AkT pathway  LEAVES  IDENTIFICATION  CONSTITUENTS  EXTRACT  MODELS  POTENT  
n-BuOH extract of Bletilla striata exerts chemopreventive effects on lung against SiO2 nanoparticles through activation of Nrf2 pathway 期刊论文
PHYTOMEDICINE, 2021, 卷号: 82, 页码: 153445
作者:  Chen,Gang;  Chang,Wenhui;  Li,Xuezheng;  Han,Longzhe;  Zhou,Di;  Feng,Yuan;  Li,Bingxin;  Zhu,Fangying;  Li,Ning
收藏  |  浏览/下载:110/0  |  提交时间:2022/04/02
Lung injury  nm SiO2  Nrf2  Chemoprevention  Gymnoside II  
Artematrolide A inhibited cervical cancer cell proliferation via ROS/ERK/mTOR pathway and metabolic shift 期刊论文
PHYTOMEDICINE, 2021, 卷号: 91, 页码: 153707
作者:  Zhang,Xin-Tian;  Hu,Jing;  Su,Li-Hua;  Geng,Chang-An;  Chen,Ji-Jun
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Artemisia atrovirens  Cervical cancer  ERK pathway  Cell metabolism  ALKALINE-PHOSPHATASE  SIGNALING PATHWAY  DIFFERENTIATION  APOPTOSIS  ERK  MECHANISMS  
Buxus alkaloid compound destabilizes mutant p53 through inhibition of the HSF1 chaperone axis 期刊论文
PHYTOMEDICINE, 2020
作者:  Wang Yu-Ling;  Wu Wei;  Su Yong-Nan;  Ai Zhi-Peng;  Mou Han-Chuan;  Wan Luo-Sheng;  Luo Ying;  Qiu Ming-Hua;  Zhang Ji-Hong
浏览  |  Adobe PDF(7972Kb)  |  收藏  |  浏览/下载:181/43  |  提交时间:2021/01/05
Effects of 23-epi-26-deoxyactein on adipogenesis in 3T3-L1 preadipocytes and diet-induced obesity in C57BL/6 mice 期刊论文
PHYTOMEDICINE, 2020
作者:  Yuan, Jingjing;  Shi, Qiangqiang;  Chen, Juan;  Lu, Jing;  Wang, Lu;  Qiu, Minghua;  Liu, Jian
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Total alkaloids from Alstonia scholaris inhibit influenza a virus replication and lung immunopathology by regulating the innate immune response 期刊论文
PHYTOMEDICINE, 2020
作者:  Zhou, Hong-Xia;  Li, Run-Feng;  Wang, Yi-Feng;  Shen, Li-Han;  Cai, Li-Hua;  Weng, Yun-Ceng;  Zhang, Huan-Rong;  Chen, Xin-Xin;  Wu, Xiao;  Chen, Rui-Feng;  Jiang, Hai-Ming;  Wang, Caiyun;  Yang, Mingrong;  Lu, Jingguang;  Luo, Xiao-Dong;  Jiang, Zhihong;  Yang, Zi-Feng
浏览  |  Adobe PDF(841Kb)  |  收藏  |  浏览/下载:213/52  |  提交时间:2021/01/05