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Oligosaccharide Blocks PAR1 (Proteinase-Activated Receptor 1)-PAR4-Mediated Platelet Activation by Binding to Thrombin Exosite II and Impairs Thrombosis 期刊论文
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2023, 卷号: 43, 期号: 2, 页码: 253-266
作者:  Li,Sujuan;  Wang,Weili;  Lin,Lisha;  Yang,Lian;  Cai,Ying;  Yang,Xingzhi;  Zhang,Taocui;  Xiao,Chuang;  Yan,Hui;  Gao,Na;  Zhao,Jinhua
浏览  |  Adobe PDF(2610Kb)  |  收藏  |  浏览/下载：5/1  |  提交时间：2024/05/09
oligosaccharide  platelet activation  receptor  protease-activated  thrombin thrombosis  ANTIPLATELET THERAPIES  ALLOSTERIC LINKAGE  TISSUE FACTOR  PROTEASE  VORAPAXAR  MECHANISM  REVEALS  SITE  
Structural Characterization and Anticoagulant Activities of a Keratan Sulfate-like Polysaccharide from the Sea Cucumber Holothuria fuscopunctata 期刊论文
MARINE DRUGS, 2023, 卷号: 21, 期号: 12, 页码: 632
作者:  Chen,Ru;  Wang,Weili;  Yin,Ronghua;  Pan,Ying;  Xu,Chen;  Gao,Na;  Luo,Xiaodong;  Zhao,Jinhua;  Reyes,Fernando
浏览  |  Adobe PDF(6775Kb)  |  收藏  |  浏览/下载：9/5  |  提交时间：2024/05/09
aminoglycan  structural features  keratan sulfate  depolymerization  oligosaccharides  anticoagulant activity  INTRINSIC-FACTOR XASE  GLYCOSAMINOGLYCAN  OLIGOSACCHARIDES  DEPOLYMERIZATION  ELUCIDATION  DERIVATIVES  HEPARIN  
FG寡糖抗凝抗血栓作用的活性特点与机制 学位论文
: 中国科学院大学, 2022
作者:  蔡英
Adobe PDF(11671Kb)  |  收藏  |  浏览/下载：1/0  |  提交时间：2024/05/14
FG寡糖，内源性因子X酶，抗凝抗血栓活性特点，止血功能  FG oligosaccharides, Intrinsic tenase, The characteristics of anticoagulant and antithrombotic activity, Haemostatic function  
FG 寡糖对血小板蛋白酶激活受体的阻断作用及机制研究 学位论文
: 中国科学院大学, 2022
作者:  李素娟
Adobe PDF(5079Kb)  |  收藏  |  浏览/下载：75/0  |  提交时间：2024/05/14
血小板活化，蛋白酶激活受体，凝血酶外位点 II，血栓，岩藻糖化糖胺 聚糖  Platelet activation, Protease-activated receptor, Thrombin exosite II, Thrombosis, Fucosylated glycosaminoglycan  
分子模拟应用于岩藻糖化糖胺聚糖 3D 结构确定及其与内源 性因子 X 酶的相互作用模式考察 学位论文
, 2021
作者:  陈鼎元
Adobe PDF(4948Kb)  |  收藏  |  浏览/下载：66/0  |  提交时间：2023/11/02
Structural characterization and anticoagulant analysis of the novel branched fucosylated glycosaminoglycan from sea cucumber Holothuria nobilis 期刊论文
CARBOHYDRATE POLYMERS, 2021, 卷号: 269, 页码: 118290
作者:  Li,Shanni;  Zhong,Wei;  Pan,Ying;  Lin,Lisha;  Cai,Ying;  Mao,Hui;  Zhang,Taocui;  Li,Sujuan;  Chen,Ru;  Zhou,Lutan;  Wang,Weili;  Cui,Qinghua;  Yin,Ronghua;  Huang,Shengxiong;  Zhao,Jinhua
浏览  |  Adobe PDF(2581Kb)  |  收藏  |  浏览/下载：178/19  |  提交时间：2022/04/02
Disaccharide branch  Fucosylated glycosaminoglycan  Holothuria nobilis  Oligosaccharide  Anticoagulant  INTRINSIC TENASE COMPLEX  CHONDROITIN SULFATE  ACAUDINA-MOLPADIOIDEA  FACTOR XASE  HEPARIN  DEPOLYMERIZATION  OLIGOSACCHARIDES  POLYSACCHARIDES  DERIVATIVES  
Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities 期刊论文
Natural products and bioprospecting, 2021, 卷号: 11, 期号: 1, 页码: 51-62
作者:  Zhu,Hong-Jie;  Xu,Te;  Yan,Yong-Ming;  Tu,Zheng-Chao;  Cheng,Yong-Xian
浏览  |  Adobe PDF(1659Kb)  |  收藏  |  浏览/下载：109/23  |  提交时间：2022/04/02
A review on the relationship of mast cells and macrophages in breast cancer - Can herbs or natural products facilitate their anti-tumor effects? 期刊论文
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 164, 页码: 105321
作者:  Gou,Leilei;  Yue,Grace Gar-Lee;  Puno,Pema Tenzin;  Lau,Clara Bik-San
浏览  |  Adobe PDF(1847Kb)  |  收藏  |  浏览/下载：62/15  |  提交时间：2022/04/02
Breast cancer  Mast cell  Macrophage  Natural products  Herbs  Extracts  TUMOR-ASSOCIATED MACROPHAGES  NF-KAPPA-B  MEDIATED ALLERGIC REACTIONS  PRO-INFLAMMATORY CYTOKINES  ANTIINFLAMMATORY ACTIVITY  ATOPIC-DERMATITIS  UMBROSA ROOT  TNF-ALPHA  IN-VIVO  C-KIT  
The Toxicology of Native Fucosylated Glycosaminoglycans and the Safety of Their Depolymerized Products as Anticoagulants 期刊论文
MARINE DRUGS, 2021, 卷号: 19, 期号: 9, 页码: 487
作者:  Lin,Lisha;  Li,Sujuan;  Gao,Na;  Wang,Weili;  Zhang,Taocui;  Yang,Lian;  Yang,Xingzhi;  Luo,Dan;  Ji,Xu;  Zhao,Jinhua
浏览  |  Adobe PDF(2854Kb)  |  收藏  |  浏览/下载：79/10  |  提交时间：2022/04/02
fucosylated glycosaminoglycan  anticoagulant  platelet aggregation  contact activation  hypotension  pulmonary embolism  CHONDROITIN SULFATE  CONTACT SYSTEM  COMPLEMENT  COAGULATION  ACTIVATION  ACCUMULATION  INVOLVEMENT  DERIVATIVES  KALLIKREIN  THROMBOSIS  
Pharmacokinetics and Pharmacodynamics of a Depolymerized Glycosaminoglycan from Holothuria fuscopunctata, a Novel Anticoagulant Candidate, in Rats by Bioanalytical Methods 期刊论文
MARINE DRUGS, 2021, 卷号: 19, 期号: 4, 页码: 212
作者:  Liu,Shuang;  Zhang,Taocui;  Sun,Huifang;  Lin,Lisha;  Gao,Na;  Wang,Weili;  Li,Sujuan;  Zhao,Jinhua
浏览  |  Adobe PDF(1230Kb)  |  收藏  |  浏览/下载：150/52  |  提交时间：2022/04/02
pharmacokinetics  pharmacodynamics  anticoagulant  fucosylated glycosaminoglycan  dHG-5  method validation