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Oligosaccharide Blocks PAR1 (Proteinase-Activated Receptor 1)-PAR4-Mediated Platelet Activation by Binding to Thrombin Exosite II and Impairs Thrombosis 期刊论文
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2023, 卷号: 43, 期号: 2, 页码: 253-266
作者:  Li,Sujuan;  Wang,Weili;  Lin,Lisha;  Yang,Lian;  Cai,Ying;  Yang,Xingzhi;  Zhang,Taocui;  Xiao,Chuang;  Yan,Hui;  Gao,Na;  Zhao,Jinhua
浏览  |  Adobe PDF(2610Kb)  |  收藏  |  浏览/下载：22/4  |  提交时间：2024/05/09
oligosaccharide  platelet activation  receptor  protease-activated  thrombin thrombosis  ANTIPLATELET THERAPIES  ALLOSTERIC LINKAGE  TISSUE FACTOR  PROTEASE  VORAPAXAR  MECHANISM  REVEALS  SITE  
High-molecular-weight fucosylated glycosaminoglycan induces human platelet aggregation depending on alpha(IIb)beta(3) and platelet secretion 期刊论文
PLATELETS, 2021, 卷号: 32, 期号: 7, 页码: 975-983
作者:  Lin,Lisha;  Yang,Lian;  Chen,Jun;  Zhou,Lutan;  Li,Sujuan;  Gao,Na;  Zhao,Jinhua
浏览  |  Adobe PDF(3733Kb)  |  收藏  |  浏览/下载：71/18  |  提交时间：2022/04/02
Aggregation  fucosylated glycosaminoglycan  human platelets  secretion  alpha(IIb beta 3)  DEPOLYMERIZED HOLOTHURIAN GLYCOSAMINOGLYCAN  INTRINSIC TENASE COMPLEX  INTEGRIN ALPHA(IIB)BETA(3)  ACTIVATION  AGGLUTINATION  RECEPTOR  ADP  INHIBITION  GENERATION  MECHANISM  
From multi-target anticoagulants to DOACs, and intrinsic coagulation factor inhibitors 期刊论文
BLOOD REVIEWS, 2020
作者:  Lin, Lisha;  Zhao, Longyan;  Gao, Na;  Yin, Ronghua;  Li, Sujuan;  Sun, Huifang;  Zhou, Lutan;  Zhao, Guiling;  Purcell, Steven W.;  Zhao, Jinhua
浏览  |  Adobe PDF(943Kb)  |  收藏  |  浏览/下载：110/27  |  提交时间：2021/01/05
High-molecular-weight fucosylated glycosaminoglycan induces human platelet aggregation depending on alpha(IIb)beta(3) and platelet secretion 期刊论文
PLATELETS, 2020
作者:  Lin, Lisha;  Yang, Lian;  Chen, Jun;  Zhou, Lutan;  Li, Sujuan;  Gao, Na;  Zhao, Jinhua
浏览  |  Adobe PDF(4004Kb)  |  收藏  |  浏览/下载：89/16  |  提交时间：2021/01/05
Nonasaccharide Inhibits Intrinsic Factor Xase Complex by Binding to Factor IXa and Disrupting Factor IXa-Factor VIIIa Interactions 期刊论文
THROMBOSIS AND HAEMOSTASIS, 2019, 卷号: 119, 期号: 5, 页码: 705-715
作者:  Xiao, Chuang;  Zhao, Longyan;  Gao, Na;  Wu, Mingyi;  Zhao, Jinhua
浏览  |  Adobe PDF(740Kb)  |  收藏  |  浏览/下载：249/67  |  提交时间：2019/06/24
nonasaccharide from fucosylated glycosaminoglycan  intrinsic factor Xase complex  factor IXa  anticoagulant  
Oligosaccharides from depolymerized fucosylated glycosaminoglycan: Structures and minimum size for intrinsic factor Xase complex inhibition 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 36, 页码: 14089-14099
作者:  Yin, Ronghua;  Zhou, Lutan;  Gao, Na;  Li, Zi;  Zhao, Longyan;  Shang, Feineng;  Wu, Mingyi;  Zhao, Jinhua
浏览  |  Adobe PDF(1313Kb)  |  收藏  |  浏览/下载：230/38  |  提交时间：2018/10/07
Natural Product  Carbohydrate Chemistry  Carbohydrate Structure  Chemical Modification  Drug Discovery  Oligosaccharide  Thrombosis  
Structural analysis and anticoagulant activities of three highly regular fucan sulfates as novel intrinsic factor Xase inhibitors 期刊论文
CARBOHYDRATE POLYMERS, 2018, 卷号: 195, 页码: 257-266
作者:  Shang, Feineng;  Mou, Rongrong;  Zhang, Zhidong;  Gao, Na;  Lin, Lisha;  Li, Zhongkun;  Wu, Mingyi;  Zhao, Jinhua
浏览  |  Adobe PDF(2021Kb)  |  收藏  |  浏览/下载：348/66  |  提交时间：2018/07/16
Fucan Sulfate  Chemical Structure  Anticoagulant  Polysaccharide  Sea Cucumber  
Plasma contact activation by a fucosylated chondroitin sulfate and its structure-activity relationship study 期刊论文
GLYCOBIOLOGY, 2018, 卷号: 28, 期号: 10, 页码: 754-764
作者:  Lin, Lisha;  Xu, Li;  Xiao, Chuang;  Zhou, Lutan;  Gao, Na;  Wu, Mingyi;  Zhao, Jinhua
浏览  |  Adobe PDF(595Kb)  |  收藏  |  浏览/下载：193/49  |  提交时间：2019/03/29
The initiation and effects of plasma contact activation: an overview 期刊论文
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2017, 卷号: 105, 期号: 3, 页码: 235-243
作者:  Lin, Lisha;  Wu, Mingyi;  Zhao, Jinhua
浏览  |  Adobe PDF(424Kb)  |  收藏  |  浏览/下载：257/44  |  提交时间：2017/05/19
Contact Activation  Kallikrein-kinin  Coagulation  Inflammation  Factor Xii  
Interactions between depolymerized fucosylated glycosaminoglycan and coagulation proteases or inhibitors 期刊论文
THROMBOSIS RESEARCH, 2016, 卷号: 146, 页码: 59-68
作者:  Xiao, Chuang;  Lian, Wu;  Zhou, Lutan;  Gao, Na;  Xua, Li;  Chen, Jun;  Wu, Mingyi;  Peng, Wenlie;  Zhao, Jinhua
浏览  |  Adobe PDF(5739Kb)  |  收藏  |  浏览/下载：363/94  |  提交时间：2017/01/05
Fucosylated Glycosaminoglycan  Coagulation Proteases  Biolayer Interferometry  Binding Kinetics  Structure-activity Relationship