| The initiation and effects of plasma contact activation: an overview | |
Lin, Lisha1,2; Wu, Mingyi1; Zhao, Jinhua1
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| 2017-03-01 | |
| 发表期刊 | INTERNATIONAL JOURNAL OF HEMATOLOGY
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| 卷号 | 105期号:3页码:235-243 |
| 摘要 | The plasma contact system sits atop the intrinsic coagulation cascade and plasma kallikrein-kinin pathway, and in vivo its activation contributes, respectively, to coagulation and inflammation mainly via two downstream pathways. This system has been widely investigated, its activation mechanisms by negatively charged surfaces and the interactions within its components, factor XII, prekallikrein and high molecular weight kininogen are well understood at the biochemical level. However, as most of the activators that have been discovered by in vitro experiments are exogenous, the physiological activators and roles of the contact system have remained unclear and controversial. In the last two decades, several physiological activators have been identified, and a better understanding of its roles and its connection with other signaling pathways has been obtained from in vivo studies. In this article, we present an overview of the contact pathway with a focus on the activation mechanisms, natural stimuli, possible physiological roles, potential risks of its excessive activation, remaining questions and future prospects. |
| 关键词 | Contact Activation Kallikrein-kinin Coagulation Inflammation Factor Xii |
| DOI | 10.1007/s12185-016-2132-x |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000394996300003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/51005 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Pharmaceut Chem, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Lisha,Wu, Mingyi,Zhao, Jinhua. The initiation and effects of plasma contact activation: an overview[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY,2017,105(3):235-243. |
| APA | Lin, Lisha,Wu, Mingyi,&Zhao, Jinhua.(2017).The initiation and effects of plasma contact activation: an overview.INTERNATIONAL JOURNAL OF HEMATOLOGY,105(3),235-243. |
| MLA | Lin, Lisha,et al."The initiation and effects of plasma contact activation: an overview".INTERNATIONAL JOURNAL OF HEMATOLOGY 105.3(2017):235-243. |
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| lin2016.pdf（424KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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