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The Toxicology of Native Fucosylated Glycosaminoglycans and the Safety of Their Depolymerized Products as Anticoagulants 期刊论文
MARINE DRUGS, 2021, 卷号: 19, 期号: 9, 页码: 487
作者:  Lin,Lisha;  Li,Sujuan;  Gao,Na;  Wang,Weili;  Zhang,Taocui;  Yang,Lian;  Yang,Xingzhi;  Luo,Dan;  Ji,Xu;  Zhao,Jinhua
浏览  |  Adobe PDF(2854Kb)  |  收藏  |  浏览/下载:97/14  |  提交时间:2022/04/02
fucosylated glycosaminoglycan  anticoagulant  platelet aggregation  contact activation  hypotension  pulmonary embolism  CHONDROITIN SULFATE  CONTACT SYSTEM  COMPLEMENT  COAGULATION  ACTIVATION  ACCUMULATION  INVOLVEMENT  DERIVATIVES  KALLIKREIN  THROMBOSIS  
High-molecular-weight fucosylated glycosaminoglycan induces human platelet aggregation depending on alpha(IIb)beta(3) and platelet secretion 期刊论文
PLATELETS, 2021, 卷号: 32, 期号: 7, 页码: 975-983
作者:  Lin,Lisha;  Yang,Lian;  Chen,Jun;  Zhou,Lutan;  Li,Sujuan;  Gao,Na;  Zhao,Jinhua
浏览  |  Adobe PDF(3733Kb)  |  收藏  |  浏览/下载:69/18  |  提交时间:2022/04/02
Aggregation  fucosylated glycosaminoglycan  human platelets  secretion  alpha(IIb beta 3)  DEPOLYMERIZED HOLOTHURIAN GLYCOSAMINOGLYCAN  INTRINSIC TENASE COMPLEX  INTEGRIN ALPHA(IIB)BETA(3)  ACTIVATION  AGGLUTINATION  RECEPTOR  ADP  INHIBITION  GENERATION  MECHANISM  
Effects of Native Fucosylated Glycosaminoglycan, Its Depolymerized Derivatives on Intrinsic Factor Xase, Coagulation, Thrombosis, and Hemorrhagic Risk 期刊论文
THROMBOSIS AND HAEMOSTASIS, 2020
作者:  Zhou, Lutan;  Gao, Na;  Sun, Huifang;  Xiao, Chuang;  Yang, Lian;  Lin, Lisha;  Yin, Ronghua;  Li, Zi;  Zhang, Hongbin;  Ji, Xu;  Zhao, Jinhua
浏览  |  Adobe PDF(1210Kb)  |  收藏  |  浏览/下载:238/55  |  提交时间:2021/01/05
From multi-target anticoagulants to DOACs, and intrinsic coagulation factor inhibitors 期刊论文
BLOOD REVIEWS, 2020
作者:  Lin, Lisha;  Zhao, Longyan;  Gao, Na;  Yin, Ronghua;  Li, Sujuan;  Sun, Huifang;  Zhou, Lutan;  Zhao, Guiling;  Purcell, Steven W.;  Zhao, Jinhua
浏览  |  Adobe PDF(943Kb)  |  收藏  |  浏览/下载:109/26  |  提交时间:2021/01/05
High-molecular-weight fucosylated glycosaminoglycan induces human platelet aggregation depending on alpha(IIb)beta(3) and platelet secretion 期刊论文
PLATELETS, 2020
作者:  Lin, Lisha;  Yang, Lian;  Chen, Jun;  Zhou, Lutan;  Li, Sujuan;  Gao, Na;  Zhao, Jinhua
浏览  |  Adobe PDF(4004Kb)  |  收藏  |  浏览/下载:88/15  |  提交时间:2021/01/05
NMR characterization and anticoagulant activity of the oligosaccharides from the fucosylated glycosaminoglycan isolated from Holothuria coluber 期刊论文
CARBOHYDRATE POLYMERS, 2020
作者:  Yang, Wenjiao;  Chen, Dingyuan;  He, Zhicheng;  Zhou, Lutan;  Cai, Ying;  Mao, Hui;  Gao, Na;  Zuo, Zhili;  Yin, Ronghua;  Zhao, Jinhua
浏览  |  Adobe PDF(2127Kb)  |  收藏  |  浏览/下载:186/73  |  提交时间:2021/01/05
Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments 期刊论文
CARBOHYDRATE POLYMERS, 2019, 卷号: 224, 页码: 10
作者:  Cai, Ying;  Yang, Wenjiao;  Li, Xiaomei;  Zhou, Lutan;  Wang, Zhongjuan;  Lin, Lisha;  Chen, Dingyuan;  Zhao, Longyan;  Li, Zhongkun;  Liu, Shubai;  Yin, Ronghua;  Zuo, Zhili;  Gao, Na;  Zhao, Jinhua
浏览  |  Adobe PDF(4714Kb)  |  收藏  |  浏览/下载:335/44  |  提交时间:2019/10/28
Fucosylated glycosaminoglycan  Oligosaccharide  Chemical structure  iXase  
Nonasaccharide Inhibits Intrinsic Factor Xase Complex by Binding to Factor IXa and Disrupting Factor IXa-Factor VIIIa Interactions 期刊论文
THROMBOSIS AND HAEMOSTASIS, 2019, 卷号: 119, 期号: 5, 页码: 705-715
作者:  Xiao, Chuang;  Zhao, Longyan;  Gao, Na;  Wu, Mingyi;  Zhao, Jinhua
浏览  |  Adobe PDF(740Kb)  |  收藏  |  浏览/下载:245/65  |  提交时间:2019/06/24
nonasaccharide from fucosylated glycosaminoglycan  intrinsic factor Xase complex  factor IXa  anticoagulant  
Precise Structure and Anticoagulant Activity of Fucosylated Glycosaminoglycan from Apostichopus japonicus: Analysis of Its Depolymerized Fragments 期刊论文
MARINE DRUGS, 2019, 卷号: 17, 期号: 4, 页码: 13
作者:  Guan, Ruowei;  Peng, Yuan;  Zhou, Lutan;  Zheng, Wenqi;  Liu, Xixi;  Wang, Pin;  Yuan, Qingxia;  Gao, Na;  Zhao, Longyan;  Zhao, Jinhua
浏览  |  Adobe PDF(2313Kb)  |  收藏  |  浏览/下载:174/6  |  提交时间:2019/06/24
Apostichopus japonicus  fucosylated glycosaminoglycan  oligosaccharide  unambiguous structure  anti-Fxase  
Oligosaccharides from depolymerized fucosylated glycosaminoglycan: Structures and minimum size for intrinsic factor Xase complex inhibition 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 36, 页码: 14089-14099
作者:  Yin, Ronghua;  Zhou, Lutan;  Gao, Na;  Li, Zi;  Zhao, Longyan;  Shang, Feineng;  Wu, Mingyi;  Zhao, Jinhua
浏览  |  Adobe PDF(1313Kb)  |  收藏  |  浏览/下载:227/38  |  提交时间:2018/10/07
Natural Product  Carbohydrate Chemistry  Carbohydrate Structure  Chemical Modification  Drug Discovery  Oligosaccharide  Thrombosis