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Sauruchinenols A and B, unprecedented monocyclic diterpenes with new carbon skeleton from the aerial parts of Saururus chinensis 期刊论文
FITOTERAPIA, 2017, 卷号: 116, 页码: 116-120
作者:  Gao, Xiu;  He, Juan;  Wu, Xing-De;  Peng, Li-Yan;  Shao, Li-Dong;  Li, Yan;  Cheng, Xiao;  Zhao, Qin-Shi
浏览  |  Adobe PDF(503Kb)  |  收藏  |  浏览/下载：326/41  |  提交时间：2017/04/18
Saururus Chinensis  Saururaceae  Sauruchinenols A-d  Anti-no Production  
Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 41, 页码: 66689-66699
作者:  Zhang, Ruowen;  Che, Xun;  Zhang, Jingjie;  Li, Yang;  Li, Jingxia;  Deng, Xu;  Zhu, Junlan;  Jin, Honglei;  Zhao, Qinshi;  Huang, Chuanshu
浏览  |  Adobe PDF(9106Kb)  |  收藏  |  浏览/下载：203/45  |  提交时间：2017/01/05
Chel a  Human Bladder Cancer  Apoptosis  Phlpp2  C-jun  
Crucial Role of c-Jun Phosphorylation at Ser63/73 Mediated by PHLPP Protein Degradation in the Cheliensisin A Inhibition of Cell Transformation 期刊论文
CANCER PREVENTION RESEARCH, 2014, 卷号: 7, 期号: 12, 页码: 1270-1281
作者:  Zhu, Junlan;  Zhang, Jingjie;  Huang, Haishan;  Li, Jingxia;  Yu, Yonghui;  Jin, Honglei;  Li, Yang;  Deng, Xu;  Gao, Jimin;  Zhao, Qinshi;  Huang, Chuanshu;  Huang,CS (reprint author),NYU,Sch Med,Nelson Inst Environm Med,57 Old Forge Rd,Tuxedo Pk,NY 10987 USA.
浏览  |  Adobe PDF(3644Kb)  |  收藏  |  浏览/下载：204/38  |  提交时间：2015/01/20
Naturally Occurring Substances  Magnetic-resonance Spectroscopy  Stem-bark  Melodinus-henryi  Conformational-analysis  (+)-scholarisine  Mechanism  Leaves  Seeds  Camptothecin  Indole Alkaloids  Cytotoxicity  Absolute Configuration  Vinca Major  
Identification and validation of p50 as the cellular target of eriocalyxin B 期刊论文
ONCOTARGET, 2014, 卷号: 5, 期号: 22, 页码: 11354-11364
作者:  Kong, Ling-Mei;  Deng, Xu;  Zuo, Zhi-Li;  Sun, Han-Dong;  Zhao, Qin-Shi;  Li, Yan
浏览  |  Adobe PDF(3014Kb)  |  收藏  |  浏览/下载：287/72  |  提交时间：2015/06/17
Erib  Activity-based Probes  P50  Nf-kappa b Signaling  Apoptosis  
Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells 期刊论文
ONCOTARGET, 2014, 卷号: 5, 期号: 3, 页码: 841-852
作者:  Zhang, Jingjie;  Gao, Guangxun;  Chen, Liang;  Li, Jingxia;  Deng, Xu;  Zhao, Qin-shi;  Huang, Chuanshu
浏览  |  Adobe PDF(3282Kb)  |  收藏  |  浏览/下载：316/66  |  提交时间：2014/05/16
Cheliensisin a  Apoptosis  Colon Cancer  P53  Chemotherapeutic Agent  
Cheliensisin A Inhibits EGF-Induced Cell Transformation with Stabilization of p53 Protein Via a Hydrogen Peroxide/Chk1-Dependent Axis 期刊论文
CANCER PREVENTION RESEARCH, 2013, 卷号: 6, 期号: 9, 页码: 949-958
作者:  Zhang, Jingjie;  Gao, Guangxun;  Chen, Liang;  Deng, Xu;  Li, Jingxia;  Yu, Yonghui;  Zhang, Dongyun;  Li, Fei;  Zhang, Min;  Zhao, Qinshi;  Huang, Chuanshu
浏览  |  Adobe PDF(1677Kb)  |  收藏  |  浏览/下载：2685/237  |  提交时间：2013/10/16
Dna-damage  Cancer Chemoprevention  Induced Phosphorylation  Activation  Apoptosis  Expression  Induction  Hyperoxia  Therapy  Roles  
Pseudolaric acid B induces apoptosis via proteasome-mediated Bcl-2 degradation in hormone-refractory prostate cancer DU145 cells 期刊论文
TOXICOLOGY IN VITRO, 2012, 卷号: 26, 期号: 4, 页码: 595-602
作者:  Zhao, Dandan;  Lin, Feng;  Wu, Xingde;  Zhao, Qinshi;  Zhao, Binjiahui;  Lin, Ping;  Zhang, Yanlong;  Yu, Xiaoguang
Adobe PDF(971Kb)  |  收藏  |  浏览/下载：854/172  |  提交时间：2012/06/07
Pseudolaric Acid b  Hormone-refractory Prostate Cancer  Apoptosis  Bcl-2 Degradation  Proteasome  Reactive Oxygen Species  
Development of novel conformation-constrained cytotoxic derivatives of cheliensisin A by embedment of small heterocycles 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 卷号: 46, 期号: 9, 页码: 4238-4244
作者:  Deng, Xu;  Su, Jia;  Zhao, Yu;  Peng, Li-Yan;  Li, Yan;  Yao, Zhu-Jun;  Zhao, Qin-Shi
Adobe PDF(450Kb)  |  收藏  |  浏览/下载：397/99  |  提交时间：2012/03/16
Cheliensisin a  Derivative  Structure-activity Relationship  Cytotoxicity  Anticancer  
Michael reaction acceptor molecules in chemical biology 期刊论文
PROGRESS IN CHEMISTRY, 2007, 卷号: 19, 期号: 12, 页码: 1972-1976
作者:  Zhao Qinshi;  Cong Yuwen
Adobe PDF(354Kb)  |  收藏  |  浏览/下载：316/124  |  提交时间：2011/12/19
Michael Reaction Acceptors  Chemical Biology  Molecule Probes  
Melissoidesin G, a diterpenoid purified from Isodon melissoides, induces leukemic-cell apoptosis through induction of redox imbalance and exhibits synergy with other anticancer agents 期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2007, 卷号: 121, 期号: 9, 页码: 2084-2094
作者:  Yu, Zu-Yin;  Liang, Yu-Guang;  Xiao, He;  Shan, Ya-Jun;  Dong, Bo;  Huang, Rui;  Fu, Ya-Li;  Zhao, Zhen-Hu;  Liu, Ze-Yuan;  Zhao, Qin-Shi;  Wang, Sheng-Qi;  Chen, Jia-Pei;  Mao, Bing-Zhi;  Cong, Yu-Wen
Adobe PDF(894Kb)  |  收藏  |  浏览/下载：308/79  |  提交时间：2011/11/24
Melissoidesin g  Leukemia  Apoptosis  Redox  Arsenic Trioxide