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Design, Synthesis, and Structural Optimization of Lycorine-Derived Phenanthridine Derivatives as Wnt/beta-Catenin Signaling Pathway Agonists 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2016, 卷号: 79, 期号: 1, 页码: 180-188
作者:  Chen, Duo-Zhi;  Jing, Chen-Xu;  Cai, Jie-Yun;  Wu, Ji-Bo;  Wang, Sheng;  Yin, Jun -Lin;  Li, Xiao-Nian;  Li, Lin;  Hao, Xiao-Jiang
浏览  |  Adobe PDF(3043Kb)  |  收藏  |  浏览/下载：321/76  |  提交时间：2016/06/27
LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp sh18 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2016, 卷号: 79, 期号: 1, 页码: 149-155
作者:  Wang, Wei-Guang;  Li, Ao;  Yan, Bing-Chao;  Niu, Shu-Bin;  Tang, Jian-Wei;  Li, Xiao-Nian;  Du, Xue;  Challis, Gregory L.;  Che, Yongsheng;  Sung, Han-Dong;  Pu, Jian-Xin
浏览  |  Adobe PDF(3283Kb)  |  收藏  |  浏览/下载：366/85  |  提交时间：2016/06/27
Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 90, 页码: 775-787
作者:  Liu, Chin-Yu;  Cheng, Yung-Yi;  Chang, Ling-Chu;  Huang, Li-Jiau;  Chou, Li-Chen;  Huang, Chi-Hung;  Tsai, Meng-Tung;  Liao, Chih-Chang;  Hsu, Mei-Hua;  Lin, Hui-Yi;  Wu, Tian-Shung;  Wen, Yen-Fang;  Zhao, Yu;  Kuo, Sheng-Chu;  Lee, Kuo-Hsiung;  Kuo,SC (reprint author),China Med Univ,Grad Inst Pharmaceut Chem,91 Hsueh Shih Rd,Taichung 40402,Taiwan.;  sckuo@mail.cmu.edu.tw;  khlee@unc.edu
浏览  |  Adobe PDF(1696Kb)  |  收藏  |  浏览/下载：347/79  |  提交时间：2015/06/29
2-arylnaphthyridin-4-ones  Antitumor Agents  Phosphate Prodrug  
Indole Alkaloids with New Skeleton Activating Neural Stem Cells 期刊论文
ORGANIC LETTERS, 2014, 卷号: 16, 期号: 21, 页码: 5808-5811
作者:  Yang, Xing-Wei;  Yang, Cui-Ping;  Jiang, Li-Ping;  Qin, Xu-Jie;  Liu, Ya-Ping;  Shen, Qiu-Shuo;  Chen, Yong-Bin;  Luo, Xiao-Dong
浏览  |  Adobe PDF(312Kb)  |  收藏  |  浏览/下载：427/85  |  提交时间：2015/01/20
Enigmatic Relationships  Bayesian Phylogenetics  Evolutionary History  C-4 Photosynthesis  Plastid Genomes  Grasses Poaceae  Tree Selection  Woody Bamboos  Mixed Models  Nuclear Loci  Branch Length  Chloroplast Phylogenomics  Data Partitioning  Low Sequence Divergence  Sampling  Temperate Woody Bamboos  
(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3 期刊论文
ORGANIC LETTERS, 2014, 卷号: 16, 期号: 2, 页码: 532-535
作者:  Yan, Yong-Ming;  Ai, Jun;  Shi, Yan-Ni;  Zuo, Zhi-Li;  Hou, Bo;  Luo, Jie;  Cheng, Yong-Xian
Adobe PDF(229Kb)  |  收藏  |  浏览/下载：453/78  |  提交时间：2014/04/09
Disease  Products  
Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum 期刊论文
ORGANIC LETTERS, 2013, 卷号: 15, 期号: 21, 页码: 5488-5491
作者:  Yan, Yong-Ming;  Ai, Jun;  Zhou, Li-Li;  Chung, Arthur C. K.;  Li, Rong;  Nie, Jing;  Fang, Ping;  Wang, Xin-Long;  Luo, Jie;  Hu, Qun;  Hou, Fan-Fan;  Cheng, Yong-Xian
Adobe PDF(299Kb)  |  收藏  |  浏览/下载：649/135  |  提交时间：2014/01/13
Diabetic-nephropathy  High-glucose  Mesangial Cells  Up-regulation  Expression  Activation  Pathways  
Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2013, 卷号: 76, 期号: 9, 页码: 1771-1780
作者:  Liu, Qian;  Tang, Jin-Shan;  Hu, Meng-Jie;  Liu, Jie;  Chen, Hai-Feng;  Gao, Hao;  Wang, Guang-Hui;  Li, Shun-Lin;  Hao, Xiao-Jiang;  Zhang, Xiao-Kun;  Yao, Xin-Sheng
浏览  |  Adobe PDF(2429Kb)  |  收藏  |  浏览/下载：219/94  |  提交时间：2015/05/13
Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11 beta-HSD1 inhibitors: Potential impact in diabetes 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 65, 页码: 403-414
作者:  Deng, Xu;  Shen, Yu;  Yang, Jing;  He, Juan;  Zhao, Yu;  Peng, Li-Yan;  Leng, Ying;  Zhao, Qin-Shi
浏览  |  Adobe PDF(1215Kb)  |  收藏  |  浏览/下载：413/154  |  提交时间：2013/10/16
Ent-kaurene Diterpenoids  Structure-activity Relationship Studies  Selective 11 Beta-hsd1 Inhibitors  Urea Derivatives  Diabetes  
Five New Nortriterpenoids from the Stems of Schisandra neglecta 期刊论文
HELVETICA CHIMICA ACTA, 2013, 卷号: 96, 期号: 7, 页码: 1376-1385
作者:  Liang, Cheng-Qin;  Hu, Jing;  Shi, Yi-Ming;  Shang, Shan-Zhai;  Du, Xue;  Zhan, Rui;  Wang, Wei-Guang;  Xiong, Wen-Yong;  Xiao, Wei-Lie;  Zhang, Hong-Bin;  Sun, Han-Dong
Adobe PDF(407Kb)  |  收藏  |  浏览/下载：362/91  |  提交时间：2014/01/13
Schisandra Neglecta  Nortriterpenoids  Triterpenoids  Insulin Sensitivity  Schicagenins D-f  Negleschidilactones a And b  
Dual-Functional abeo-Taxane Derivatives Destabilizing Microtubule Equilibrium and Inhibiting NF-kappa B Activation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 56, 期号: 11, 页码: 4749-4757
作者:  Zhao, Yu;  Su, Jia;  Goto, Masuo;  Morris-Natschke, Susan L.;  Li, Yan;  Zhao, Qin-Shi;  Yao, Zhu-Jun;  Lee, Kuo-Hsiung
浏览  |  Adobe PDF(531Kb)  |  收藏  |  浏览/下载：319/68  |  提交时间：2013/10/16
Natural-products  Biological-activity  Cancer-therapy  Paclitaxel  Taxol  Resistance  Drugs  Chemotherapy  Parthenolide  Brevifoliol