| Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria | |
Liu, Qian1; Tang, Jin-Shan1; Hu, Meng-Jie2; Liu, Jie2 ; Chen, Hai-Feng2; Gao, Hao1; Wang, Guang-Hui2; Li, Shun-Lin3; Hao, Xiao-Jiang3; Zhang, Xiao-Kun2,4; Yao, Xin-Sheng1
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| 2013-09-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| 卷号 | 76期号:9页码:1771-1780 |
| 摘要 | Phytochemical investigation of the latex of Antiaris toxicaria resulted in the isolation of 15 new [antiarosides J-X (1-15)] and 17 known cardiac glycosides. The effects of the cardiac glycosides on apoptosis and the expression of orphan nuclear receptor Nur77 were examined in human NIH-H460 lung cancer cells. Several of the cardiac glycosides induced apoptosis in lung cancer cells, which was accompanied by induction of Nur77 protein expression. Treatment of cancer cells with the cardiac glycosides resulted in translocation of the Nur77 protein from the nucleus to the cytoplasm and subsequent targeting to mitochondria. The results show that the cardiac glycosides exert their apoptotic effect through the Nur77-dependent apoptotic pathway. |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000330331200033 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/19230 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China 2.Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 4.Sanford Burnham Med Res Inst, Ctr Canc, La Jolla, CA 92037 USA |
| 推荐引用方式 GB/T 7714 | Liu, Qian,Tang, Jin-Shan,Hu, Meng-Jie,et al. Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(9):1771-1780. |
| APA | Liu, Qian.,Tang, Jin-Shan.,Hu, Meng-Jie.,Liu, Jie.,Chen, Hai-Feng.,...&Yao, Xin-Sheng.(2013).Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria.JOURNAL OF NATURAL PRODUCTS,76(9),1771-1780. |
| MLA | Liu, Qian,et al."Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria".JOURNAL OF NATURAL PRODUCTS 76.9(2013):1771-1780. |
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| np4005147.pdf（2429KB） | 开放获取 | CC BY-NC-ND | 浏览 下载 | |||
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