中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria
作者: Liu, Qian1; Tang, Jin-Shan1; Hu, Meng-Jie2; Liu, Jie2; Chen, Hai-Feng2; Gao, Hao1; Wang, Guang-Hui2; Li, Shun-Lin3; null(郝小江)3; Zhang, Xiao-Kun2, 4; Yao, Xin-Sheng1
刊名: JOURNAL OF NATURAL PRODUCTS
英文摘要: Phytochemical investigation of the latex of Antiaris toxicaria resulted in the isolation of 15 new [antiarosides J-X (1-15)] and 17 known cardiac glycosides. The effects of the cardiac glycosides on apoptosis and the expression of orphan nuclear receptor Nur77 were examined in human NIH-H460 lung cancer cells. Several of the cardiac glycosides induced apoptosis in lung cancer cells, which was accompanied by induction of Nur77 protein expression. Treatment of cancer cells with the cardiac glycosides resulted in translocation of the Nur77 protein from the nucleus to the cytoplasm and subsequent targeting to mitochondria. The results show that the cardiac glycosides exert their apoptotic effect through the Nur77-dependent apoptotic pathway.
出版日期: 2013-09-01
卷号: 76, 期号:9, 页码:1771-1780
语种: 英语
收录类别: SCI ; IC
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/19230
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
np4005147.pdf(2429KB)----开放获取View Download

作者单位: 1.Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China
2.Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
4.Sanford Burnham Med Res Inst, Ctr Canc, La Jolla, CA 92037 USA
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Qian]'s Articles
[Tang, Jin-Shan]'s Articles
[Hu, Meng-Jie]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Qian]‘s Articles
[Tang, Jin-Shan]‘s Articles
[Hu, Meng-Jie]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: np4005147.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace