Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria
Liu, Qian1; Tang, Jin-Shan1; Hu, Meng-Jie2; Liu, Jie2; Chen, Hai-Feng2; Gao, Hao1; Wang, Guang-Hui2; Li, Shun-Lin3; Hao, Xiao-Jiang3; Zhang, Xiao-Kun2,4; Yao, Xin-Sheng1
2013-09-01
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号76期号:9页码:1771-1780
摘要Phytochemical investigation of the latex of Antiaris toxicaria resulted in the isolation of 15 new [antiarosides J-X (1-15)] and 17 known cardiac glycosides. The effects of the cardiac glycosides on apoptosis and the expression of orphan nuclear receptor Nur77 were examined in human NIH-H460 lung cancer cells. Several of the cardiac glycosides induced apoptosis in lung cancer cells, which was accompanied by induction of Nur77 protein expression. Treatment of cancer cells with the cardiac glycosides resulted in translocation of the Nur77 protein from the nucleus to the cytoplasm and subsequent targeting to mitochondria. The results show that the cardiac glycosides exert their apoptotic effect through the Nur77-dependent apoptotic pathway.
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000330331200033
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/19230
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China
2.Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
4.Sanford Burnham Med Res Inst, Ctr Canc, La Jolla, CA 92037 USA
推荐引用方式
GB/T 7714
Liu, Qian,Tang, Jin-Shan,Hu, Meng-Jie,et al. Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(9):1771-1780.
APA Liu, Qian.,Tang, Jin-Shan.,Hu, Meng-Jie.,Liu, Jie.,Chen, Hai-Feng.,...&Yao, Xin-Sheng.(2013).Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria.JOURNAL OF NATURAL PRODUCTS,76(9),1771-1780.
MLA Liu, Qian,et al."Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria".JOURNAL OF NATURAL PRODUCTS 76.9(2013):1771-1780.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
np4005147.pdf(2429KB) 开放获取CC BY-NC-ND请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Qian]的文章
[Tang, Jin-Shan]的文章
[Hu, Meng-Jie]的文章
百度学术
百度学术中相似的文章
[Liu, Qian]的文章
[Tang, Jin-Shan]的文章
[Hu, Meng-Jie]的文章
必应学术
必应学术中相似的文章
[Liu, Qian]的文章
[Tang, Jin-Shan]的文章
[Hu, Meng-Jie]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。