LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp sh18
Wang, Wei-Guang1; Li, Ao2; Yan, Bing-Chao1,3; Niu, Shu-Bin4; Tang, Jian-Wei1,3; Li, Xiao-Nian1; Du, Xue1; Challis, Gregory L.5; Che, Yongsheng4; Sung, Han-Dong1; Pu, Jian-Xin1
2016
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume79Issue:1Pages:149-155
AbstractPenicilfuranone A (1), a novel furancarboxylic acid, and its proposed biosynthetic precursor, gregatin A (2), were isolated from the cultures of the fungus Penicillium sp. sh18 endophytic to the stems of Isodon eriocalyx var. laxiflora guided by HPLC-MS. X-ray crystallography was applied to the structure determination of furancarboxylic acid for the first time, allowing unambiguous assignment of 1. Penicilfuranone A displays a significant antifibrotic effect in activated hepatic stellate cells via negative regulation of transforming growth factor-beta (TGF-beta)/Smad signaling.
DOI10.1021/acs.jnatprod.5b00814
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000368755000019
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/25943
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chongqing Univ Technol, Coll Pharm & Bioengn, Chongqing 400054, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Beijing Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing 100850, Peoples R China
5.Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
Recommended Citation
GB/T 7714
Wang, Wei-Guang,Li, Ao,Yan, Bing-Chao,et al. LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp sh18[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(1):149-155.
APA Wang, Wei-Guang.,Li, Ao.,Yan, Bing-Chao.,Niu, Shu-Bin.,Tang, Jian-Wei.,...&Pu, Jian-Xin.(2016).LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp sh18.JOURNAL OF NATURAL PRODUCTS,79(1),149-155.
MLA Wang, Wei-Guang,et al."LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp sh18".JOURNAL OF NATURAL PRODUCTS 79.1(2016):149-155.
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