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Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity 期刊论文
BMC Cancer, 2019, 卷号: 19, 期号: 1
作者:  Wang,Ning;  Fan,Yanhua;  Yuan,Chun-Mao;  Song,Jialei;  Yao,Yao;  Liu,Wuling;  Gajendran,Babu;  Zacksenhaus,Eldad;  Li,Yanmei;  Liu,Jielin;  Hao,Xiao Jiang;  Ben-David,Yaacov
收藏  |  浏览/下载：151/0  |  提交时间：2019/08/13
Cancer  Leukemia  Chinese medicinal plant  Melia azedarach  Drug screen  ERK1/2 agonists  Differentiation  Apoptosis  
Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 365, 页码: 71-83
作者:  Wang, Jing-Nan;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan;  Zhang, Zhi-Rong;  Li, Ning;  Li, Ren-Da;  Wan, Jun;  Sun, Han-Dong;  Sun, Nan;  Puno, Pema-Tenzin;  He, Jie
浏览  |  Adobe PDF(3457Kb)  |  收藏  |  浏览/下载：319/72  |  提交时间：2019/03/18
Acetyl-macrocalin B  Reactive oxygen species  p38 MAPK  Chk1/Chk2  Esophageal squamous cell carcinoma  
Naphthomycin-derived macrolactams with two new carbon skeletons from endophytic Streptomyces 期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2019, 卷号: 6, 期号: 2, 页码: 177-182
作者:  Zhang, Zhouxin;  Cao, Pei;  Shang, Ning-Ning;  Yang, Jing;  Wang, Li;  Yan, Yijun;  Huang, Sheng-Xiong
浏览  |  Adobe PDF(990Kb)  |  收藏  |  浏览/下载：217/40  |  提交时间：2019/03/18
NF-kappa B and JNK mediated apoptosis and G(0)/G(1) arrest of HeLa cells induced by rubiarbonol G, an arborinane-type triterpenoid from Rubia yunnanensis 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2018, 卷号: 220, 页码: 220-227
作者:  Zeng, Guang-Zhi;  Wang, Zhe;  Zhao, Li-Mei;  Fan, Jun-Ting;  Tan, Ning-Hua
收藏  |  浏览/下载：215/0  |  提交时间：2018/07/16
Rubiarbonol g  Rubia Yunnanensis  Cytotoxicity  Mechanism  
Nematicidal quinone derivatives from three & IT;Rubia & IT; plants 期刊论文
TETRAHEDRON, 2018, 卷号: 74, 期号: 17, 页码: 2115-2120
作者:  Zhao, Si-Meng;  Kuang, Bin;  Zeng, Guang-Zhi;  Wang, Zhe;  Wang, Jia;  Chen, Xiao-Qiang;  Tan, Ning-Hua
浏览  |  Adobe PDF(696Kb)  |  收藏  |  浏览/下载：244/49  |  提交时间：2018/05/31
Rubia  Rubia Alata  Rubia Wallichiana  Rubia Schumanniana  Quinones  Nematicidal Activity  
Rubipodanones A-D, naphthohydroquinone dimers from rhizomes of &ITRubia podantha &IT 期刊论文
PHYTOCHEMISTRY, 2018, 卷号: 145, 页码: 153-160
作者:  Wang, Zhe;  Zhao, Si-Meng;  Hu, Yan-Yun;  Feng, Li;  Zhao, Li-Mei;  Di, Ying-Tong;  Tan, Ning-Hua
浏览  |  Adobe PDF(1384Kb)  |  收藏  |  浏览/下载：251/53  |  提交时间：2018/05/08
Rubia Podantha  Rubiaceae  Naphthohydroquinone Dimers  Rubipodanones A-d  Cytotoxicity  Nf-kappa b Signaling Pathway  
Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer 期刊论文
CANCER BIOLOGY & THERAPY, 2018, 卷号: 19, 期号: 7, 页码: 609-621
作者:  Wang, Jing-Nan;  Zhang, Zhi-Rong;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan;  Li, Ning;  Wan, Jun;  Sun, Han-Dong;  Sun, Nan;  Puno, Pema-Tenzin;  He, Jie
收藏  |  浏览/下载：220/0  |  提交时间：2018/07/16
Acetyl-macrocalin B  reactive oxygen species  p38 MAPK  apoptosis  Chk1  Chk2  G2  M phase arrest  NSCLC  
(+/-)-Rubioncolin D, a pair of enantiomeric naphthohydroquinone dimers from Rubia oncotricha 期刊论文
TETRAHEDRON LETTERS, 2017, 卷号: 58, 期号: 31, 页码: 3041-3043
作者:  Zhao, Si-Meng;  Wang, Zhe;  Chen, Xiao-Qiang;  Huang, Mao-Bo;  Tan, Ning-Hua
浏览  |  Adobe PDF(926Kb)  |  收藏  |  浏览/下载：203/52  |  提交时间：2017/10/23
Rubio Oncotricha  Naphthohydroquinone Dimers  Rubioncolin d  
Ptotective effects of cycloartane triterpenoides from Passiflora edulis Sims against glutamate-induced neurotoxicity in PC12 cell 期刊论文
FITOTERAPIA, 2016, 卷号: 115, 期号: 1, 页码: 122-127
作者:  Xu, Feng-Qing;  Wang, Ning;  Fan, Wei-Wei;  Zi, Cheng-Ting;  Zhao, Hong-Su;  Hu, Jiang-Miao;  Zhou, Jun
浏览  |  Adobe PDF(947Kb)  |  收藏  |  浏览/下载：225/43  |  提交时间：2017/02/14
Passiflora Edulis Sims  Cycloartane Triterpenoid  Pc12  Glutamate-induced Neurotoxicity  
Synthesis, Neuro-protection and Anti-cancer Activities of Simple Isatin Mannich and Schiff Bases 期刊论文
LETTERS IN DRUG DESIGN & DISCOVERY, 2016, 卷号: 13, 期号: 5, 页码: 395-400
作者:  Chen, Gang;  Ning, Yang;  Zhao, Wei;  Zhang, Yanqiu;  Zhang, Yu;  Hao, Xiaojiang;  Wang, Ye;  Mu, Shuzhen
浏览  |  Adobe PDF(1361Kb)  |  收藏  |  浏览/下载：268/75  |  提交时间：2016/08/22
Isatin  Mannich Base  Schiff Base  Synthesis  Neuro-protection  Anti-tumor