| Synthesis, Neuro-protection and Anti-cancer Activities of Simple Isatin Mannich and Schiff Bases | |
Chen, Gang1,2; Ning, Yang1; Zhao, Wei1; Zhang, Yanqiu1; Zhang, Yu2 ; Hao, Xiaojiang2,3,4; Wang, Ye3,4; Mu, Shuzhen3,4
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| 2016 | |
| 发表期刊 | LETTERS IN DRUG DESIGN & DISCOVERY
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| 卷号 | 13期号:5页码:395-400 |
| 摘要 | The study of isatin, as well as its kind of derivatives, has become a hot topic for a long time. To explore the new compounds and bioactivities, in this work, a series of simple isatin Mannich and Schiff bases was synthesized through the condensation reaction. The structures of these synthesized compounds were characterized using NMR and MS. Furthermore, structure of one of these compounds (IMS-4) was studied by using single crystal X-ray diffraction. Then the anti-tumor and neuro-protection activities of these compounds were evaluated. The results showed that several compounds show protection activity on the PC12 cells apoptosis induced by H2O2, which are more effective than that of (+/-) alpha-Tocophreol (VE). Besides, some compounds also show anti-tumor activity against A549 and P388 cell lines more potent than that of isatin. |
| 关键词 | Isatin Mannich Base Schiff Base Synthesis Neuro-protection Anti-tumor |
| DOI | 10.2174/1570180812666150907203342 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000374883700006 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/26222 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 701165, Shaanxi, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 3.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China 4.Chinese Acad Sci, Guiyang 550002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Gang,Ning, Yang,Zhao, Wei,et al. Synthesis, Neuro-protection and Anti-cancer Activities of Simple Isatin Mannich and Schiff Bases[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2016,13(5):395-400. |
| APA | Chen, Gang.,Ning, Yang.,Zhao, Wei.,Zhang, Yanqiu.,Zhang, Yu.,...&Mu, Shuzhen.(2016).Synthesis, Neuro-protection and Anti-cancer Activities of Simple Isatin Mannich and Schiff Bases.LETTERS IN DRUG DESIGN & DISCOVERY,13(5),395-400. |
| MLA | Chen, Gang,et al."Synthesis, Neuro-protection and Anti-cancer Activities of Simple Isatin Mannich and Schiff Bases".LETTERS IN DRUG DESIGN & DISCOVERY 13.5(2016):395-400. |
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| 007AJ.pdf（1361KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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