Naphthomycin-derived macrolactams with two new carbon skeletons from endophytic Streptomyces
Zhang, Zhouxin1,2; Cao, Pei1; Shang, Ning-Ning1,2; Yang, Jing1; Wang, Li1,2; Yan, Yijun1; Huang, Sheng-Xiong1
2019-01-21
发表期刊ORGANIC CHEMISTRY FRONTIERS
ISSN2052-4129
卷号6期号:2页码:177-182
摘要Chemical investigation of an endophytic Streptomyces strain led to the isolation of naphthomycin congeners 1-4. Compound 1 contains a unique phenalene scaffold with a bridged oxetane ring, which was confirmed to be a result of an intramolecular [2 + 2] cycloaddition between the olefin and the ketone in the known compound 4 by chemical conversion. 2 features an unprecedented acenaphthene moiety in the ansamycin class of polyketides. Possible biosynthetic pathways are proposed for 1-3. Compounds 1-3 were tested for cytotoxicity against selected human cancer cell lines and they showed moderate activity, with IC50 values ranging from 10.6 mu M to 32.5 mu M.
收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/64227
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Huang, Sheng-Xiong
作者单位1.Chinese Acad Sci, Kunming Inst Bot, CAS Ctr Excellence Mol Plant Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Zhang, Zhouxin,Cao, Pei,Shang, Ning-Ning,et al. Naphthomycin-derived macrolactams with two new carbon skeletons from endophytic Streptomyces[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(2):177-182.
APA Zhang, Zhouxin.,Cao, Pei.,Shang, Ning-Ning.,Yang, Jing.,Wang, Li.,...&Huang, Sheng-Xiong.(2019).Naphthomycin-derived macrolactams with two new carbon skeletons from endophytic Streptomyces.ORGANIC CHEMISTRY FRONTIERS,6(2),177-182.
MLA Zhang, Zhouxin,et al."Naphthomycin-derived macrolactams with two new carbon skeletons from endophytic Streptomyces".ORGANIC CHEMISTRY FRONTIERS 6.2(2019):177-182.
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