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Identification of potential AMPK activator by pharmacophore modeling, molecular docking and QSAR study 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 卷号: 79, 页码: 165-176
Authors:  Li, Yingying;  Peng, Jiale;  Li, Penghua;  Du, Haibo;  Li, Yaping;  Liu, Xingyong;  Zhang, Li;  Wang, Liang-Liang;  Zuo, Zhili
Favorite  |  View/Download:5/0  |  Submit date:2019/07/29
Pharmacophore modeling  Molecular docking  Quantitative structure activity relationship (QSAR)  Molecular dynamics  AMPK  Activator  
Discovery of novel indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors by virtual screening 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 卷号: 78, 页码: 306-316
Authors:  Zhou, Yeheng;  Peng, Jiale;  Li, Penghua;  Du, Haibo;  Li, Yaping;  Li, Yingying;  Zhang, Li;  Sun, Wei;  Liu, Xingyong;  Zuo, Zhili
Favorite  |  View/Download:32/0  |  Submit date:2019/03/25
IDO1  Molecular docking  HipHop pharmacophore  3D-QSAR  PAINS  
2,3-二氢-4(1H)-喹唑啉酮类化合物及其药物组合物和其应用 专利
申请日期: 2019-01-08, 公开日期: 2019-03-29
Inventors:  左之利;  杨淬;  汪亮亮;  李朋华;  高俐
Favorite  |  View/Download:2/0  |  Submit date:2019/08/14
Recent Topics in Research and Development of Opioid Drugs 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 卷号: 38, 期号: 10, 页码: 2625-2632
Authors:  Pan Chenling;  Meng Hao;  Wang Liangliang;  Shen Yuchai;  Zuo Zhili;  Wang Guanlin;  Chang Kwen-jen
Favorite  |  View/Download:85/0  |  Submit date:2018/12/18
opioid drug  opioid receptor  opioid side effects  drug research  
Pharmacophore modeling, molecular docking and molecular dynamics simulations toward identifying lead compounds for Chk1 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2018, 卷号: 76, 页码: 53-60
Authors:  Li, Yaping;  Peng, Jiale;  Zhou, Yeheng;  Li, Penghua;  Li, Yingying;  Liu, Xingyong;  Siddique, Abu Nasar;  Zhang, Li;  Zuo, Zhili
Favorite  |  View/Download:20/0  |  Submit date:2018/11/12
Checkpoint kinase 1 inhibitor  Virtual screening  Pharmacophore modeling  Molecular docking  Molecular dynamics simulations  
Discovery of novel wee1 inhibitors via structure-based virtual screening and biological evaluation 期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2018, 卷号: 32, 期号: 9, 页码: 901-915
Authors:  Li, Yaping;  Pu, Yinglan;  Liu, Hui;  Zhang, Li;  Liu, Xingyong;  Li, Yan;  Zuo, Zhili
Favorite  |  View/Download:307/0  |  Submit date:2018/11/06
Wee1 inhibitors  Pharmacophore model  Molecular docking  Virtual screening  Molecular dynamics simulation  
苯并噻唑类及苯并吡咯类化合物在制备抗肿瘤药物中的应用 专利
申请日期: 2018-06-28, 公开日期: 2018-10-16
Inventors:  左之利;  李雅萍;  张树群;  刘兴勇;  李艳;  张利
Favorite  |  View/Download:5/0  |  Submit date:2019/08/14
Protein Aggregation and Performance Optimization Based on Microconformational Changes of Aromatic Hydrophobic Regions 期刊论文
MOLECULAR PHARMACEUTICS, 2018, 卷号: 15, 期号: 6, 页码: 2257-2267
Authors:  Wen, Lili;  Lyu, Man;  Xiao, Huashuai;  Lan, Hairong;  Zuo, Zhili;  Yin, Zongning
Favorite  |  View/Download:23/0  |  Submit date:2018/07/16
Protein Aggregation  Aromatic Hydrophobic Regions  Amine Compounds  Guanidine Compounds  Microconformational Change  
青蒿素-苯胺基喹唑啉类衍生物及其制备方法和应用 专利
申请日期: 2018-05-16, 公开日期: 2018-09-04
Inventors:  左之利;  张树群;  刘辉;  李艳;  张云琴;  汪亮亮
Favorite  |  View/Download:4/0  |  Submit date:2019/08/14
苄烯叉苯肽类化合物及其药物组合物和其应用 专利
申请日期: 2018-05-16, 公开日期: 2018-11-06
Inventors:  左之利;  孙威;  彭佳乐;  孔德信;  周业珩
Favorite  |  View/Download:4/0  |  Submit date:2019/08/14