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Catalyzed Synthesis of 3-hydroxy-indol-2-one Derivatives as a Novel Phosphodiesterases 10 Inhibitor 期刊论文
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2020, 卷号: 126, 页码: 33-34
Authors:  Wu, Ya;  Li, Hao;  Yan, Jiao;  Cai, Qing;  Huang, Shengxiong;  Tang, Ying;  Ji, Yue;  Hao, Xiaojiang;  Chen, Gang
Favorite  |  View/Download:14/0  |  Submit date:2020/03/24
Design, synthesis, and cytotoxic activities of novel hybrids of parthenolide and thiazolidinedione via click chemistry 期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2019, 页码: 9
Authors:  Qiu, Jie;  Yuan, Chun-Mao;  Wen, Min;  Li, Ya-Nan;  Chen, Juan;  Jian, Jun-You;  Huang, Lie-Jun;  Gu, Wei;  Li, Yan-Mei;  Hao, Xiao-Jiang
View  |  Adobe PDF(1093Kb)  |  Favorite  |  View/Download:51/1  |  Submit date:2019/07/29
Parthenolide-thiazolidinedione hybrids  click chemistry  cytotoxic activities  
Nukiangendines A and B, two novel 13,14-seco-abietanes from Abies nukiangensis 期刊论文
TETRAHEDRON LETTERS, 2019, 卷号: 60, 期号: 10, 页码: 751-753
Authors:  Li, Yong-Li;  Zhang, Qiang;  Wu, Jian-Jun;  Xue, Li-Jun;  Chen, Li-Ming;  Tian, Jun-Mian;  Xu, Zhuo-Ni;  Chen, Ying;  Yang, Xian-Wen;  Hao, Xiao-Jiang;  Li, Jie
View  |  Adobe PDF(561Kb)  |  Favorite  |  View/Download:107/0  |  Submit date:2019/04/15
Abies nukiangensis  seco-Abietane  Diterpene  Antiviral  
Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 84, 页码: 285-294
Authors:  Chen, Duo-zhi;  Yang, Bi-juan;  He, Xiao-li;  Fan, Shi-rui;  Cai, Jie-yun;  Jing, Chen-xu;  Zhang, Heng;  Zhang, Yu;  Li, Lin;  Hao, Xiao-jiang
View  |  Adobe PDF(3047Kb)  |  Favorite  |  View/Download:121/0  |  Submit date:2019/03/18
Wnt/beta-catenin signalling pathway agonist  Phenanthridine derivatives  Structural optimization  Structure-activity relationships (SARs)  
Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis 期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 11
Authors:  Liu, Tangjingjun;  Xia, Lei;  Yao, Yao;  Yan, Chen;  Fan, Yanhua;  Gajendran, Babu;  Yang, Jue;  Li, You-Jun;  Chen, Juan;  Filmus, Jorge;  Spaner, David E.;  Zacksenhaus, Eldad;  Hao, Xiaojiang;  Ben-David, Yaacov
View  |  Adobe PDF(2055Kb)  |  Favorite  |  View/Download:131/0  |  Submit date:2019/04/15
Efficient synthesis of new phenanthridine Wnt/beta-catenin signaling pathway agonists 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 1491-1499
Authors:  Chen, Duozhi;  Zhang, Heng;  Jing, Chenxu;  He, Xiaoli;  Yang, Bijuan;  Cai, Jieyun;  Zhou, Yunfu;  Song, Xiaoming;  Li, Lin;  Hao, Xiaojiang
Favorite  |  View/Download:299/0  |  Submit date:2018/11/12
Wnt/beta-catenin signaling agonist  Phenanthridine derivatives  Structural optimization  
The plant sesquiterpene lactone parthenolide inhibits Wnt/-catenin signaling by blocking synthesis of the transcriptional regulators TCF4/LEF1 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 14, 页码: 5335-5344
Authors:  Zhu, Xiaoliang;  Yuan, Chunmao;  Tian, Chenyang;  Li, Chen;  Nie, Fen;  Song, Xiaomin;  Zeng, Rong;  Wu, Dianqing;  Hao, Xiaojiang;  Li, Lin
Favorite  |  View/Download:347/0  |  Submit date:2018/05/08
Inhibitor  Protein Synthesis  Small Molecule  T-cell Factor (Tcf)  Wnt Signaling  
Efficient synthesis of new phenanthridine Wnt/b-catenin signaling pathway agonists 期刊论文
European Journal of Medicinal Chemistry, 2018, 卷号: 157, 页码: 1491-1499
Authors:  Duozhi Chen;  Heng Zhang;  Chenxu Jing;  Xiaoli He;  Bijuan Yang;  Jieyun Cai;  Yunfu Zhou;  Xiaoming Song;  Lin Li;  Xiaojiang Hao
View  |  Adobe PDF(1966Kb)  |  Favorite  |  View/Download:86/35  |  Submit date:2019/03/27
Anti-TMV Effects of Amaryllidaceae Alkaloids Isolated from the Bulbs ofLycoris radiata and Lycoricidine Derivatives. 期刊论文
Natural products and bioprospecting, 2018, 卷号: 8, 期号: 3, 页码: 189-197
Authors:  Yang, Dong-Qiong;  Chen, Zhao-Rong;  Chen, Duo-Zhi;  Hao, Xiao-Jiang;  Li, Shun-Lin
Favorite  |  View/Download:30/0  |  Submit date:2019/03/29
Cytotoxic indole alkaloids from Melodinus khasianus and Melodinus tenuicaudatus 期刊论文
FITOTERAPIA, 2018, 卷号: 128, 页码: 204-212
Authors:  Yi, Wen-fang;  Chen, Duo-zhi;  Ding, Xiao;  Li, Xiao-nian;  Li, Shun-lin;  Di, Ying-tong;  Zhang, Yu;  Hao, Xiao-jiang
Favorite  |  View/Download:60/0  |  Submit date:2018/12/27