Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity
Li,Ya-Nan; Zeng,Yan-Rong; Yang,Jue; He,Wenwen; Chen,Junlei; Deng,Lulu; Yi,Ping; Huang,Lie-Jun; Gu,Wei; Hu,Zhan-Xing; Yuan,Chun-Mao; Hao,Xiao-Jiang
Source PublicationPHYTOCHEMISTRY
AbstractHypericum monogynum L. (Hypericaceae) has been used as a folk Chinese medicine for the treatment of in-flammatory related diseases. Cyclooxygenase-2 (COX-2) is a crucial target for the development of agents to treat inflammation. To search for anti-inflammatory compounds from traditional Chinese medicines, a chemical constituent study along with COX-2 inhibitory activity analysis was performed for this plant. In this study, sixteen chemical monomers, including three undescribed oxidative degradation polycyclic polyprenylated acylphloroglucinols (PPAPs, hypemoins C-E), two undescribed PPAPs (hypemoins A and B), and 11 known compounds, were identified from the flowers of H. monogynum. Their structures were characterized by HRESIMS, NMR techniques, ECD, and single crystal X-ray diffraction. Four flavonoid derivatives showed remarkable COX-2 inhibitory activities, with IC50 values ranging from 0.220 +/- 0.006 to 1.655 +/- 0.098 mu M. Among these compounds, the possible recognition mechanism between quercetin 3-(6-O-caffeoyl)-beta-3-D-galactoside and COX-2 was predicted by molecular docking analysis. Moreover, the multidrug resistance reversal activities for the selected compounds were evaluated.
KeywordHypericum monogynum L. Hypericaceae Chemical constituents Polycyclic polyprenylated acylphloroglucinols Flavonoids COX-2 inhibitors
WOS IDWOS:000715094900001
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Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.[Li, Ya-Nan
2.Zeng, Yan-Rong
3.Yang, Jue
4.He, Wenwen
5.Chen, Junlei
6.Deng, Lulu
7.Yi, Ping
8.Huang, Lie-Jun
9.Gu, Wei
10.Hu, Zhan-Xing
11.Yuan, Chun-Mao
12.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China
13.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Peoples R China
14.Chinese Acad Sci, Guiyang 550014, Peoples R China
15.Guizhou Minzu Univ, Sch Ethn Med, Guiyang 550025, Peoples R China
16.Chinese Acad Sci, Kunming Inst Boanty, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
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GB/T 7714
Li,Ya-Nan,Zeng,Yan-Rong,Yang,Jue,et al. Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity[J]. PHYTOCHEMISTRY,2022,193:112970.
APA Li,Ya-Nan.,Zeng,Yan-Rong.,Yang,Jue.,He,Wenwen.,Chen,Junlei.,...&Hao,Xiao-Jiang.(2022).Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity.PHYTOCHEMISTRY,193,112970.
MLA Li,Ya-Nan,et al."Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity".PHYTOCHEMISTRY 193(2022):112970.
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