Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity

doi:10.1016/j.phytochem.2021.112970

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	Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity
	Li,Ya-Nan ; Zeng,Yan-Rong ; Yang,Jue ; He,Wenwen ; Chen,Junlei ; Deng,Lulu ; Yi,Ping ; Huang,Lie-Jun ; Gu,Wei; Hu,Zhan-Xing ; Yuan,Chun-Mao ; Hao,Xiao-Jiang
	2022
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	193 页码:112970
摘要	Hypericum monogynum L. (Hypericaceae) has been used as a folk Chinese medicine for the treatment of in-flammatory related diseases. Cyclooxygenase-2 (COX-2) is a crucial target for the development of agents to treat inflammation. To search for anti-inflammatory compounds from traditional Chinese medicines, a chemical constituent study along with COX-2 inhibitory activity analysis was performed for this plant. In this study, sixteen chemical monomers, including three undescribed oxidative degradation polycyclic polyprenylated acylphloroglucinols (PPAPs, hypemoins C-E), two undescribed PPAPs (hypemoins A and B), and 11 known compounds, were identified from the flowers of H. monogynum. Their structures were characterized by HRESIMS, NMR techniques, ECD, and single crystal X-ray diffraction. Four flavonoid derivatives showed remarkable COX-2 inhibitory activities, with IC50 values ranging from 0.220 +/- 0.006 to 1.655 +/- 0.098 mu M. Among these compounds, the possible recognition mechanism between quercetin 3-(6-O-caffeoyl)-beta-3-D-galactoside and COX-2 was predicted by molecular docking analysis. Moreover, the multidrug resistance reversal activities for the selected compounds were evaluated.
关键词	Hypericum monogynum L. Hypericaceae Chemical constituents Polycyclic polyprenylated acylphloroglucinols Flavonoids COX-2 inhibitors
DOI	10.1016/j.phytochem.2021.112970
WOS记录号	WOS:000715094900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73103
专题	中国科学院昆明植物研究所
作者单位	1.[Li, Ya-Nan 2.Zeng, Yan-Rong 3.Yang, Jue 4.He, Wenwen 5.Chen, Junlei 6.Deng, Lulu 7.Yi, Ping 8.Huang, Lie-Jun 9.Gu, Wei 10.Hu, Zhan-Xing 11.Yuan, Chun-Mao 12.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China 13.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Peoples R China 14.Chinese Acad Sci, Guiyang 550014, Peoples R China 15.Guizhou Minzu Univ, Sch Ethn Med, Guiyang 550025, Peoples R China 16.Chinese Acad Sci, Kunming Inst Boanty, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Li,Ya-Nan,Zeng,Yan-Rong,Yang,Jue,et al. Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity[J]. PHYTOCHEMISTRY,2022,193:112970.
APA	Li,Ya-Nan.,Zeng,Yan-Rong.,Yang,Jue.,He,Wenwen.,Chen,Junlei.,...&Hao,Xiao-Jiang.(2022).Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity.PHYTOCHEMISTRY,193,112970.
MLA	Li,Ya-Nan,et al."Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity".PHYTOCHEMISTRY 193(2022):112970.