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Discovery of a potent and selective adenylyl cyclase type 8 agonist by docking-based virtual screening 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 2, 页码: 7
作者:  Weng, Zhiying;  Xu, Guowei;  Chen, Dingyuan;  Yang, Yaqing;  Song, Gao;  Shen, Wen;  Zhang, Shuqun;  Wang, LiangLiang;  Yang, Weimin;  Zuo, Zhili
收藏  |  浏览/下载：162/0  |  提交时间：2020/03/18
Adenylyl cyclases  Homology modeling  Consensus scoring  Molecular dynamics simulation  Virtual screening  Biological evaluation  
Homology modeling and 3D-QSAR study of benzhydrylpiperazine delta opioid receptor agonists 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 卷号: 83, 页码: 9
作者:  Pan, Chenling;  Meng, Hao;  Zhang, Shuqun;  Zuo, Zhili;  Shen, Yuehai;  Wang, Liangliang;  Chang, Kwen-Jen
浏览  |  Adobe PDF(1542Kb)  |  收藏  |  浏览/下载：267/73  |  提交时间：2020/03/18
delta opioid receptor agonists  3D-QSAR  Homology modeling  Molecular dynamics simulation  Molecular docking  
Synthesis and antitumor evaluation of neolaxiflorin B inspired compounds 期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2019, 卷号: 13, 页码: 3021-3028
作者:  Liu, Jing-Ping;  Xiao, Ye-Zhi;  Hu, Yu;  Li, Xiao-Nian;  Wu, Ming-Jiang;  Zhao, Yong;  Zhao, Yan;  Ma, Ze-Jin;  Shen, Jing
浏览  |  Adobe PDF(551Kb)  |  收藏  |  浏览/下载：129/33  |  提交时间：2019/10/28
neolaxiflorin B inspired compounds  unsaturated ketone  antitumor activity  
Recent Topics in Research and Development of Opioid Drugs 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 卷号: 38, 期号: 10, 页码: 2625-2632
作者:  Pan Chenling;  Meng Hao;  Wang Liangliang;  Shen Yuchai;  Zuo Zhili;  Wang Guanlin;  Chang Kwen-jen
收藏  |  浏览/下载：241/0  |  提交时间：2018/12/18
opioid drug  opioid receptor  opioid side effects  drug research  
Teuvincenone F Suppresses LPS-Induced Inflammation and NLRP3 Inflammasome Activation by Attenuating NEMO Ubiquitination 期刊论文
FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8, 页码: 565
作者:  Zhao, Xibao;  Pu, Debing;  Zhao, Zizhao;  Zhu, Huihui;  Li, Hongrui;  Shen, Yaping;  Zhang, Xingjie;  Zhang, Ruihan;  Shen, Jianzhong;  Xiao, Weilie;  Chen, Weilin
浏览  |  Adobe PDF(3100Kb)  |  收藏  |  浏览/下载：165/53  |  提交时间：2017/10/23
Teuvincenone f  Inflammation  Nlrp3 Inflammasome  Ubiquitination  Nemo  
The opioid receptor triple agonist DPI-125 produces analgesia with less respiratory depression and reduced abuse liability 期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 977-989
作者:  Yi, Shou-pu;  Kong, Qing-hong;  Li, Yu-lei;  Pan, Chen-ling;  Yu, Jie;  Cui, Ben-qiang;  Wang, Ying-fei;  Wang, Guan-lin;  Zhou, Pei-lan;  Wang, Li-li;  Gong, Ze-hui;  Su, Rui-bin;  Shen, Yue-hai;  Yu, Gang;  Chang, Kwen-jen
浏览  |  Adobe PDF(854Kb)  |  收藏  |  浏览/下载：338/66  |  提交时间：2017/08/29
Opioid Receptor  Mixed Agonist  Dpi-125  Analgesia  Respiratory Depression  Addiction  
Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 11, 页码: 4680-4692
作者:  Qu, Chunrong;  Ding, Mingmin;  Zhu, Yingmin;  Lu, Yungang;  Du, Juan;  Miller, Melissa;  Tian, Jinbin;  Zhu, Jinmei;  Xui, Jian;  Wen, Meng;  Er-Bu, Aga;  Wan, Jule;  Xiao, Yuling;  Wu, Meng;  McManus, Owen B.;  Li, Min;  Wu, Jilin;  Luo, Huai-Rong;  Cao, Zhengyu;  Shen, Bing;  Wang, Hongbo;  Zhu, Michael X.;  Hong, Xuechuan
浏览  |  Adobe PDF(1969Kb)  |  收藏  |  浏览/下载：206/77  |  提交时间：2017/08/29
Chemical Constituents of Capparis spinosa 期刊论文
CHEMISTRY OF NATURAL COMPOUNDS, 2017, 卷号: 53, 页码: 557-558
作者:  Hu, Dongbao;  Zhang, Shen;  Li, Ming;  Wu, Xianxue
浏览  |  Adobe PDF(130Kb)  |  收藏  |  浏览/下载：151/56  |  提交时间：2017/07/18
Four new diterpenoid alkaloids with antitumor effect from Aconitum nagarum var. heterotrichum 期刊论文
CHINESE CHEMICAL LETTERS, 2017, 卷号: 28, 期号: 2, 页码: 358-361
作者:  Zhao, Da-Ke;  Shi, Xing-Qiao;  Zhang, Li-Mei;  Yang, Dong-Qiong;  Guo, Hua-Chun;  Chen, Yan-Ping;  Shen, Yong
浏览  |  Adobe PDF(1397Kb)  |  收藏  |  浏览/下载：185/38  |  提交时间：2017/04/19
Ranunculaceae  Aconitum Nagarum Var. Heterotrichum  Diterpenoid Alkaloids  Nagaconitines A-d  Antitumor Activity  
Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2016, 卷号: 116, 页码: 39-50
作者:  Zhou, Hongyu;  Shang, Chaowei;  Wang, Min;  Shen, Tao;  Kong, Lingmei;  Yu, Chunlei;  Ye, Zhennan;  Luo, Yan;  Liu, Lei;  Li, Yan;  Huang, Shile
浏览  |  Adobe PDF(3794Kb)  |  收藏  |  浏览/下载：175/36  |  提交时间：2017/01/05
Ciclopirox  Mtor  Ampk  Tsc2  Raptor