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Discovery of a potent and selective adenylyl cyclase type 8 agonist by docking-based virtual screening 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 2, 页码: 7
Authors:  Weng, Zhiying;  Xu, Guowei;  Chen, Dingyuan;  Yang, Yaqing;  Song, Gao;  Shen, Wen;  Zhang, Shuqun;  Wang, LiangLiang;  Yang, Weimin;  Zuo, Zhili
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Adenylyl cyclases  Homology modeling  Consensus scoring  Molecular dynamics simulation  Virtual screening  Biological evaluation  
Homology modeling and 3D-QSAR study of benzhydrylpiperazine delta opioid receptor agonists 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 卷号: 83, 页码: 9
Authors:  Pan, Chenling;  Meng, Hao;  Zhang, Shuqun;  Zuo, Zhili;  Shen, Yuehai;  Wang, Liangliang;  Chang, Kwen-Jen
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delta opioid receptor agonists  3D-QSAR  Homology modeling  Molecular dynamics simulation  Molecular docking  
2,3-二氢-4(1H)-喹唑啉酮类化合物及其药物组合物和其应用 专利
申请日期: 2019-01-08, 公开日期: 2019-03-29
Inventors:  左之利;  杨淬;  汪亮亮;  李朋华;  高俐
Favorite  |  View/Download:80/0  |  Submit date:2019/08/14
Recent Topics in Research and Development of Opioid Drugs 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 卷号: 38, 期号: 10, 页码: 2625-2632
Authors:  Pan Chenling;  Meng Hao;  Wang Liangliang;  Shen Yuchai;  Zuo Zhili;  Wang Guanlin;  Chang Kwen-jen
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opioid drug  opioid receptor  opioid side effects  drug research  
青蒿素-苯胺基喹唑啉类衍生物及其制备方法和应用 专利
申请日期: 2018-05-16, 公开日期: 2018-09-04
Inventors:  左之利;  张树群;  刘辉;  李艳;  张云琴;  汪亮亮
Favorite  |  View/Download:27/0  |  Submit date:2019/08/14
阿片类药物研发近期热点 期刊论文
有机化学, 2018, 页码: 10
Authors:  潘陈玲;  孟浩;  汪亮亮;  沈悦海;  左之利;  王冠林;  张宽仁
Favorite  |  View/Download:36/0  |  Submit date:2018/11/26
阿片药物  阿片受体  阿片样副作用  药物研究  
Discovery of FIXa inhibitors by combination of pharmacophore modeling, molecular docking, and 3D-QSAR modeling 期刊论文
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2018, 卷号: 38, 期号: 3, 页码: 246-255
Authors:  Li, Penghua;  Peng, Jiale;  Zhou, Yeheng;  Li, Yaping;  Liu, XingYong;  Wang, LiangLiang;  Zuo, ZhiLi
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Chloroplast phylogeography of the East Asian Arcto-Tertiary relict Tetracentron sinense (Trochodendraceae) 期刊论文
JOURNAL OF BIOGEOGRAPHY, 2014, 卷号: 41, 期号: 9, 页码: 1721-1732
Authors:  Sun, Yanxia;  Moore, Michael J.;  Yue, Liangliang;  Feng, Tao;  Chu, Haijia;  Chen, Shaotian;  Ji, Yunheng;  Wang, Hengchang;  Li, Jianqiang;  Wang,HC (reprint author),Chinese Acad Sci,Wuhan Bot Garden,Wuhan,Hubei,Peoples R China.;  hcwang@wbgcas.cn;  lijq@wbgcas.cn
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China  Climate Change  Conservation  Interglacial Period  Neogene  Pleistocene  Range Expansion  Refugia  
1-氢-2-吲哚酮-3-苄基/取代苄基-3-甲酸酯类化合物的新用途 专利
公开日期: 2018-06-01
Inventors:  翁稚颖;  左之利;  杨为民;  张树群;  沈雯;  汪亮亮;  宋杲;  杨雅清;  徐国伟
Favorite  |  View/Download:52/0  |  Submit date:2018/10/24