| Four new diterpenoid alkaloids with antitumor effect from Aconitum nagarum var. heterotrichum | |
| Zhao, Da-Ke1; Shi, Xing-Qiao1; Zhang, Li-Mei2; Yang, Dong-Qiong3; Guo, Hua-Chun2; Chen, Yan-Ping2; Shen, Yong2 | |
| 2017-02-01 | |
| 发表期刊 | CHINESE CHEMICAL LETTERS
 |
| 卷号 | 28期号:2页码:358-361 |
| 摘要 | Four new diterpenoid alkaloids, nagaconitines A-D (1-4), were isolated from the roots of Aconitum nagarum var. heterotrichum. Their structures were elucidated as 8-(4'-hydroxylbutyryl) aconitine (1), 15-oxo-13-deoxyludaconitine (2), 15-hydroxyldelphisine (3), and 14-hydroxyl-2- acetoxyspiradine C (4) based on extensive UV, IR, MS, 1D NMR and 2D NMR analyses. Compounds 3-4 showed inhibition of cancer cell line SK-OV-3 with 31% (IC50 43.78 mu mol/L) and 24% (IC50 32.14 mu mol/L), respectively. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| 关键词 | Ranunculaceae Aconitum Nagarum Var. Heterotrichum Diterpenoid Alkaloids Nagaconitines A-d Antitumor Activity |
| DOI | 10.1016/j.cclet.2016.09.012 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000393929300036 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/46031 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Sch Agr, Kunming 650091, Peoples R China 2.Yunnan Agr Univ, Coll Agr & Biotechnol, Kunming 650201, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Da-Ke,Shi, Xing-Qiao,Zhang, Li-Mei,et al. Four new diterpenoid alkaloids with antitumor effect from Aconitum nagarum var. heterotrichum[J]. CHINESE CHEMICAL LETTERS,2017,28(2):358-361. |
| APA | Zhao, Da-Ke.,Shi, Xing-Qiao.,Zhang, Li-Mei.,Yang, Dong-Qiong.,Guo, Hua-Chun.,...&Shen, Yong.(2017).Four new diterpenoid alkaloids with antitumor effect from Aconitum nagarum var. heterotrichum.CHINESE CHEMICAL LETTERS,28(2),358-361. |
| MLA | Zhao, Da-Ke,et al."Four new diterpenoid alkaloids with antitumor effect from Aconitum nagarum var. heterotrichum".CHINESE CHEMICAL LETTERS 28.2(2017):358-361. |
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| zhao2016.pdf（1397KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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