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The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP)1 期刊论文
出版物, 3111, 期号: 0, 页码: 1-42
Authors:  C Pergola;  J Gerstmeier;  B Monch;  B Çaliskan;  S Luderer;  C Weinige;  D Barz;  J Maczewsky;  S Pace;  A Rossi;  L Sautebin;  E Banoglu;  O Werz
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Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1 期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2019, 卷号: 32, 期号: 10, 页码: 1965-1976
Authors:  Yang, Xiao-Nan;  Wang, Yi-Kun;  Zhu, Xu;  Xiao, Xue-Rong;  Dai, Man-Yun;  Zhang, Ting;  Qu, Yan;  Yang, Xiu-Wei;  Qin, Hong-Bo;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(9057Kb)  |  Favorite  |  View/Download:2/0  |  Submit date:2020/03/26
Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 29, 页码: 8243-8252
Authors:  Wang, Yi-Kun;  Yang, Xiao-Nan;  Zhu, Xu;  Xiao, Xue-Rong;  Yang, Xiu-Wei;  Qin, Hong-Bo;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(3136Kb)  |  Favorite  |  View/Download:14/0  |  Submit date:2019/09/10
elemicin  l'-hydroxyelemicin  metabolic activation  cytotoxicity  
Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2019, 卷号: 176, 期号: 13, 页码: 2162-2178
Authors:  Zhao, Qi;  Zhang, Ting;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Wang, Yan;  Gonzalez, Frank J.;  Li, Fei
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A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice 期刊论文
XENOBIOTICA, 2019, 卷号: 49, 期号: 6, 页码: 655-670
Authors:  Wang, Yi-Kun;  Yang, Xiao-Nan;  Liang, Wei-Qing;  Xiao, Yao;  Zhao, Qi;  Xiao, Xue-Rong;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(1101Kb)  |  Favorite  |  View/Download:32/0  |  Submit date:2019/07/29
Pazopanib  hepatotoxicity  metabolomics  oxidative stress  ultra-performance liquid chromatography-electrospray ion source-quadrupole  time-of-flight mass spectrometer (UPLC-ESI-QTOFMS)  
The sources and mechanisms of bioactive ingredients in coffee 期刊论文
FOOD & FUNCTION, 2019, 卷号: 10, 期号: 6, 页码: 3113-3126
Authors:  Hu, G. L.;  Wang, X.;  Zhang, L.;  Qiu, M. H.
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Characterization of a sesquiterpene cyclase from the glandular trichomes of Leucosceptrum canum for sole production of cedrol in Escherichia coli and Nicotiana benthamiana 期刊论文
PHYTOCHEMISTRY, 2019, 卷号: 162, 页码: 121-128
Authors:  Luo, Fei;  Ling, Yi;  Li, De-Sen;  Tang, Ting;  Liu, Yan-Chun;  Liu, Yan;  Li, Sheng-Hong
View  |  Adobe PDF(2851Kb)  |  Favorite  |  View/Download:24/0  |  Submit date:2019/07/29
Leucosceptrum canum  Lamiaceae  Cedrol  Sesquiterpene cylase  Cedrol synthase  Heterologous production  Synthetic biology  
Metabolic Activation of Myristicin and Its Role in Cellular Toxicity 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 15, 页码: 4328-4336
Authors:  Zhu, Xu;  Wang, Yi-Kun;  Yang, Xiao-Nan;  Xiao, Xue-Rong;  Zhang, Ting;  Yang, Xiu-Wei;  Qin, Hong-Bo;  Li, Fei
View  |  Adobe PDF(4316Kb)  |  Favorite  |  View/Download:68/0  |  Submit date:2019/05/24
myristicin  1 '-hydroxymyristicin  metabolic activation  metabolomics  
Metabolic profiling of the anti-tumor drug regorafenib in mice 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 卷号: 159, 页码: 524-535
Authors:  Wang, Yi-Kun;  Xiao, Xue-Rong;  Xu, Kang-Ping;  Li, Fei
Favorite  |  View/Download:17/0  |  Submit date:2018/10/04
Regorafenib  Metabolomics  Multiple mass defect filters  Molecular docking  
Research Progress of Polycyclic Polyprenylated Acylphloroglucinols 期刊论文
CHEMICAL REVIEWS, 2018, 卷号: 118, 期号: 7, 页码: 3508-3558
Authors:  Yang, Xing-Wei;  Grossman, Robert B.;  Xu, Gang
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