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Discovery and bioinspired total syntheses of unprecedented sesquiterpenoid dimers unveiled bifurcating [4+2] cycloaddition and target differentiation of enantiomers 期刊论文
CHEMICAL SCIENCE, 2024, 卷号: 15, 期号: 4
作者:  He, Tao-Bin;  Yan, Bing-Chao;  Zhou, Yuan-Fei;  Sang, Yue-Qian;  Li, Xiao-Nian;  Sun, Han-Dong;  Wang, Chu;  Xue, Xiao-Song;  Puno, Pema-Tenzin
Adobe PDF(3322Kb)  |  收藏  |  浏览/下载:10/1  |  提交时间:2024/05/09
DIELS-ALDER REACTION  BIOMIMETIC SYNTHESES  EFFICIENT ACCESS  DEHYDROGENATION  CYCLOHEXANONES  BIOSYNTHESIS  CONVERSION  OXIDATION  DYNAMICS  PHENOLS  
Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 365, 页码: 71-83
作者:  Wang, Jing-Nan;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan;  Zhang, Zhi-Rong;  Li, Ning;  Li, Ren-Da;  Wan, Jun;  Sun, Han-Dong;  Sun, Nan;  Puno, Pema-Tenzin;  He, Jie
Adobe PDF(3457Kb)  |  收藏  |  浏览/下载:293/64  |  提交时间:2019/03/18
Acetyl-macrocalin B  Reactive oxygen species  p38 MAPK  Chk1/Chk2  Esophageal squamous cell carcinoma  
Rabdocoestin B exhibits antitumor activity by inducing G2/M phase arrest and apoptosis in esophageal squamous cell carcinoma 期刊论文
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2018, 卷号: 81, 期号: 3, 页码: 469-481
作者:  Wang, Jingnan;  Zhang, Zhirong;  Che, Yun;  Yuan, Zuyang;  Lu, Zhiliang;  Li, Yuan;  Wan, Jun;  Sun, Handong;  Chen, Zhaoli;  Pu, Jianxin;  He, Jie
收藏  |  浏览/下载:291/0  |  提交时间:2018/05/08
Rabdocoestin b  G2/m Phase Arrest  Apoptosis  Cytotoxicity  Esophageal Squamous Cell Carcinoma  
Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer 期刊论文
CANCER BIOLOGY & THERAPY, 2018, 卷号: 19, 期号: 7, 页码: 609-621
作者:  Wang, Jing-Nan;  Zhang, Zhi-Rong;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan;  Li, Ning;  Wan, Jun;  Sun, Han-Dong;  Sun, Nan;  Puno, Pema-Tenzin;  He, Jie
收藏  |  浏览/下载:213/0  |  提交时间:2018/07/16
Acetyl-macrocalin B  reactive oxygen species  p38 MAPK  apoptosis  Chk1  Chk2  G2  M phase arrest  NSCLC  
大萼香茶菜乙素二乙酰化物的药物新用途 专利
申请日期: 2017-10-16, 公开日期: 2018-02-02
发明人:  赫捷;  普建新;  王婧男;  孙汉董;  孙楠;  吴海燕;  高亦博
Adobe PDF(3053Kb)  |  收藏  |  浏览/下载:143/0  |  提交时间:2018/05/10
TEMPORARY REMOVAL: The therapeutic effects of Longikaurin A, a natural ent-kauranoid, in esophageal squamous cell carcinoma depend on ROS accumulation and JNK/p38 MAPK activation (Retraction of Vol 280, Pg 1, 2017) 期刊论文
TOXICOLOGY LETTERS, 2017, 卷号: 280, 页码: 106-106
作者:  Che, Yun;  Wang, Jingnan;  Yuan, Zuyang;  Li, Yuan;  Lu, Zhiliang;  Zhang, Zhirong;  Zhang, Jinyao;  Wan, Jun;  Sun, Handong;  Chen, Zhaoli;  Pu, Jianxin;  He, Jie
收藏  |  浏览/下载:182/0  |  提交时间:2017/12/18
细锥香茶菜乙素在制备抑制食管鳞癌细胞增殖的产品中的应用 专利
申请日期: 2017-05-05, 公开日期: 2017-09-29
发明人:  赫捷;  普建新;  陈照丽;  孙汉董;  王婧男;  吴海燕
Adobe PDF(1872Kb)  |  收藏  |  浏览/下载:185/0  |  提交时间:2018/05/10
Unusual cycloartane triterpenoids from Kadsura ananosma 期刊论文
PHYTOCHEMISTRY, 2015, 卷号: 109, 期号: 1, 页码: 36-42
作者:  Yang,Jian-Hong;  Pu,Jian-Xin;  Wen,Jin;  Li,Xiao-Nian;  He,Fei;  Su,Jia;  Li,Yan;  Sun,Han-Dong
Adobe PDF(674Kb)  |  收藏  |  浏览/下载:280/73  |  提交时间:2015/06/29
Kadsura Ananosma  Schisandraceae  Cycloartane Triterpenoids  Ananosins  
Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2015, 卷号: 78, 期号: 1, 页码: 10-16
作者:  Yao, Ran;  Chen, Zhaoli;  Zhou, Chengcheng;  Luo, Mei;  Shi, Xuejiao;  Li, Jiagen;  Gao, Yibo;  Zhou, Fang;  Pu, Jianxin;  Sun, Handong;  He, Jie
浏览  |  Adobe PDF(6589Kb)  |  收藏  |  浏览/下载:274/57  |  提交时间:2015/06/29
Heterodimeric ent-Kauranoids from Isodon tenuifolius 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2014, 卷号: 77, 期号: 11, 页码: 2444-2453
作者:  Yang, Jian-Hong;  Wang, Wei-Guang;  Du, Xue;  He, Fei;  Zhang, Hai-Bo;  Li, Xiao-Nian;  Li, Yan;  Pu, Jian-Xin;  Sun, Han-Dong
浏览  |  Adobe PDF(438Kb)  |  收藏  |  浏览/下载:292/68  |  提交时间:2015/01/20
Immunosuppressive Polyketides  5-aminolevulinic Acid  Assay  Marine-associated Fungus  Daldinia Eschscholzii  Secondary Metabolites  Hydrolysis  Gc Analysis  X-ray Diffraction Analysis