Heterodimeric ent-Kauranoids from Isodon tenuifolius
Yang, Jian-Hong1,2; Wang, Wei-Guang1; Du, Xue1; He, Fei1; Zhang, Hai-Bo1; Li, Xiao-Nian1; Li, Yan1; Pu, Jian-Xin1; Sun, Han-Dong1

Thirteen new heterodimeric ent-kauranoids, bistenuifolins A-M (1-13), were isolated from the aerial parts of Isodon tenuifolius. The constituent units of compounds 1-6 were linked by a six-membered dihydropyran ring, while those of compounds 7-11 were joined by a rare single carbon-carbon bond (C-16 -> C-17'). The constituent units of 12 and 13 were linked via an unusual cyclobutane moiety. The structures of these metabolites were established via spectrometric analyses, and the absolute configurations of 1 and 4 were defined by single-crystal X-ray diffraction. Selected compounds were evaluated for their cytotoxicity against a small panel of human tumor cell lines; bistenuifolin B (2) exhibited weak inhibitory effects.

KeywordImmunosuppressive Polyketides 5-aminolevulinic Acid Assay Marine-associated Fungus Daldinia Eschscholzii Secondary Metabolites Hydrolysis Gc Analysis X-ray Diffraction Analysis
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
Indexed BySCI ; IC
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000345472100017
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Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Yang, Jian-Hong,Wang, Wei-Guang,Du, Xue,et al. Heterodimeric ent-Kauranoids from Isodon tenuifolius[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(11):2444-2453.
APA Yang, Jian-Hong.,Wang, Wei-Guang.,Du, Xue.,He, Fei.,Zhang, Hai-Bo.,...&Sun, Han-Dong.(2014).Heterodimeric ent-Kauranoids from Isodon tenuifolius.JOURNAL OF NATURAL PRODUCTS,77(11),2444-2453.
MLA Yang, Jian-Hong,et al."Heterodimeric ent-Kauranoids from Isodon tenuifolius".JOURNAL OF NATURAL PRODUCTS 77.11(2014):2444-2453.
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