Heterodimeric ent-Kauranoids from Isodon tenuifolius
Yang, Jian-Hong1,2; Wang, Wei-Guang1; Du, Xue1; He, Fei1; Zhang, Hai-Bo1; Li, Xiao-Nian1; Li, Yan1; Pu, Jian-Xin1; Sun, Han-Dong1; Pu,JX (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Kunming 650201,Peoples R China.; pujianxin@mail.kib.ac.cn
2014-11-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号77期号:11页码:2444-2453
产权排序第一
摘要Thirteen new heterodimeric ent-kauranoids, bistenuifolins A-M (1-13), were isolated from the aerial parts of Isodon tenuifolius. The constituent units of compounds 1-6 were linked by a six-membered dihydropyran ring, while those of compounds 7-11 were joined by a rare single carbon-carbon bond (C-16 -> C-17'). The constituent units of 12 and 13 were linked via an unusual cyclobutane moiety. The structures of these metabolites were established via spectrometric analyses, and the absolute configurations of 1 and 4 were defined by single-crystal X-ray diffraction. Selected compounds were evaluated for their cytotoxicity against a small panel of human tumor cell lines; bistenuifolin B (2) exhibited weak inhibitory effects.
关键词Immunosuppressive Polyketides 5-aminolevulinic Acid Assay Marine-associated Fungus Daldinia Eschscholzii Secondary Metabolites Hydrolysis Gc Analysis X-ray Diffraction Analysis
资助信息MFLU grant [56101020032]; MFLU grant [56101020032]; Mushroom Research Foundation, Chiang Rai, Thailand; Chinese Academy of Sciences [2013T2S0030]; Humidtropics, a CGIAR Research Program; Japan Society for the Promotion of Science (JSPS) [25440199]; Distinguished Scientist Fellowship Program (DSFP), King Saud University, Saudi Arabia; Mushroom Research Foundation, Chiang Rai, Thailand; Chinese Academy of Sciences [2013T2S0030]; Humidtropics, a CGIAR Research Program; Japan Society for the Promotion of Science (JSPS) [25440199]; Distinguished Scientist Fellowship Program (DSFP), King Saud University, Saudi Arabia
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np5005196
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000345472100017
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18457
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Pu,JX (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Kunming 650201,Peoples R China.; pujianxin@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
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Yang, Jian-Hong,Wang, Wei-Guang,Du, Xue,et al. Heterodimeric ent-Kauranoids from Isodon tenuifolius[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(11):2444-2453.
APA Yang, Jian-Hong.,Wang, Wei-Guang.,Du, Xue.,He, Fei.,Zhang, Hai-Bo.,...&pujianxin@mail.kib.ac.cn.(2014).Heterodimeric ent-Kauranoids from Isodon tenuifolius.JOURNAL OF NATURAL PRODUCTS,77(11),2444-2453.
MLA Yang, Jian-Hong,et al."Heterodimeric ent-Kauranoids from Isodon tenuifolius".JOURNAL OF NATURAL PRODUCTS 77.11(2014):2444-2453.
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