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Alkaloids from Ochrosia borbonica 期刊论文
HELVETICA CHIMICA ACTA, 2013, 卷号: 96, 期号: 12, 页码: 2288-2298
作者:  Zhang, Bing-Jie;  Yan, Ju-Ming;  Wu, Zi-Kun;  Liu, Ya-Ping;  Bao, Mei-Fen;  Cheng, Gui-Guang;  Luo, Xiao-Dong;  Cai, Xiang-Hai;  Li, Yan
Adobe PDF(208Kb)  |  收藏  |  浏览/下载：302/77  |  提交时间：2014/01/21
Ochrosia Borbonica  Indole Alkaloids  Alkaloids  Ochroborines a And b  Cytotoxic Activity  
Cytotoxic Indole Alkaloids from Tabernaemontana divaricata 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2013, 卷号: 76, 期号: 8, 页码: 1406-1412
作者:  Bao, Mei-Fen;  Yan, Ju-Ming;  Cheng, Gui-Guang;  Li, Xing-Yao;  Liu, Ya-Ping;  Li, Yan;  Cai, Xiang-Hai;  Luo, Xiao-Dong
浏览  |  Adobe PDF(286Kb)  |  收藏  |  浏览/下载：305/92  |  提交时间：2013/10/16
Iboga Alkaloids  Bisindole Alkaloids  Apocynaceae  Corymbosa  
Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 66, 页码: 423-437
作者:  Liu, Lan-Xiang;  Wang, Xue-Quan;  Yan, Ju-Ming;  Li, Yan;  Sun, Cheng-Jun;  Chen, Wen;  Zhou, Bei;  Zhang, Hong-Bin;  Yang, Xiao-Dong
浏览  |  Adobe PDF(3339Kb)  |  收藏  |  浏览/下载：339/143  |  提交时间：2013/10/16
Hybrid Compound  Imidazole  Dibenzo[b  Antitumor Activities  d]Furan  Structure-activity Relationships  
Three unusual sesquineolignans from Alpinia conchigera 期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2013, 卷号: 15, 期号: 8, 页码: 833-839
作者:  Xu, Jun-Ju;  Zhao, Hong-Mei;  Shen, Yong;  Chen, Jian-Hua;  Li, Yan;  Tan, Ning-Hua;  Yang, Sheng-Chao
浏览  |  Adobe PDF(118Kb)  |  收藏  |  浏览/下载：208/49  |  提交时间：2013/10/16
Zingiberaceae  Alpinia Conchigera  Sesquineolignans  Conchignans A-c  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：256/43  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.