| Cytotoxic Indole Alkaloids from Tabernaemontana divaricata | |
Bao, Mei-Fen1,2; Yan, Ju-Ming1,2; Cheng, Gui-Guang1,2; Li, Xing-Yao1,2; Liu, Ya-Ping1; Li, Yan1 ; Cai, Xiang-Hai1; Luo, Xiao-Dong1
| |
| 通讯作者 | Cai, XH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; xhcai@mail.kib.ac.cn ; xdluo@mail.kib.ac.cn |
| 2013-08-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
 |
| ISSN | 0163-3864 |
| 卷号 | 76期号:8页码:1406-1412 |
| 摘要 | Five new vobasinyl-ibogan-type bisindole alkaloids, tabernaricatines A-E (1-5), two new monomers, tabernaricatines F and G (6 and 7), and 24 known indole alkaloids were isolated from the aerial parts of Tabernaemontana divaricata. Alkaloids 1 and 2 are the first vobasinyl-ibogan-type alkaloids possessing a six-membered ring via an ether linkage between C-17 and C-21. All compounds except for 3 were evaluated for their cytotoxicity against five human cancer cell lines; conophylline showed significant bioactivity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cells with IC50 values of 0.17, 0.35, 0.21, 1.02, and 1.49 mu M, respectively. |
| 关键词 | Iboga Alkaloids Bisindole Alkaloids Apocynaceae Corymbosa |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1021/np400130y |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000323630500003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16711 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bao, Mei-Fen,Yan, Ju-Ming,Cheng, Gui-Guang,et al. Cytotoxic Indole Alkaloids from Tabernaemontana divaricata[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(8):1406-1412. |
| APA | Bao, Mei-Fen.,Yan, Ju-Ming.,Cheng, Gui-Guang.,Li, Xing-Yao.,Liu, Ya-Ping.,...&Luo, Xiao-Dong.(2013).Cytotoxic Indole Alkaloids from Tabernaemontana divaricata.JOURNAL OF NATURAL PRODUCTS,76(8),1406-1412. |
| MLA | Bao, Mei-Fen,et al."Cytotoxic Indole Alkaloids from Tabernaemontana divaricata".JOURNAL OF NATURAL PRODUCTS 76.8(2013):1406-1412. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Bao-2013-Cytotoxic I（286KB） | 开放获取 | -- | 浏览 下载 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论