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题名: Cytotoxic Indole Alkaloids from Tabernaemontana divaricata
作者: Bao, Mei-Fen1, 2; Yan, Ju-Ming1, 2; Cheng, Gui-Guang1, 2; Li, Xing-Yao1, 2; Liu, Ya-Ping1; null(李艳)1; null(蔡祥海)1; null(罗晓东)1
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: IBOGA ALKALOIDS ; BISINDOLE ALKALOIDS ; APOCYNACEAE ; CORYMBOSA
英文摘要: Five new vobasinyl-ibogan-type bisindole alkaloids, tabernaricatines A-E (1-5), two new monomers, tabernaricatines F and G (6 and 7), and 24 known indole alkaloids were isolated from the aerial parts of Tabernaemontana divaricata. Alkaloids 1 and 2 are the first vobasinyl-ibogan-type alkaloids possessing a six-membered ring via an ether linkage between C-17 and C-21. All compounds except for 3 were evaluated for their cytotoxicity against five human cancer cell lines; conophylline showed significant bioactivity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cells with IC50 values of 0.17, 0.35, 0.21, 1.02, and 1.49 mu M, respectively.
出版日期: 2013-08-01
卷号: 76, 期号:8, 页码:1406-1412
DOI标识: 10.1021/np400130y
语种: 英语
ISSN号: 0163-3864
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16711
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Bao, Mei-Fen; Yan, Ju-Ming; Cheng, Gui-Guang; Li, Xing-Yao; Liu, Ya-Ping; Li, Yan; Cai, Xiang-Hai; Luo, Xiao-Dong.Cytotoxic Indole Alkaloids from Tabernaemontana divaricata,JOURNAL OF NATURAL PRODUCTS,2013,76(8):1406-1412
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