Cytotoxic Indole Alkaloids from Tabernaemontana divaricata
Bao, Mei-Fen1,2; Yan, Ju-Ming1,2; Cheng, Gui-Guang1,2; Li, Xing-Yao1,2; Liu, Ya-Ping1; Li, Yan1; Cai, Xiang-Hai1; Luo, Xiao-Dong1
2013-08-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号76期号:8页码:1406-1412
摘要Five new vobasinyl-ibogan-type bisindole alkaloids, tabernaricatines A-E (1-5), two new monomers, tabernaricatines F and G (6 and 7), and 24 known indole alkaloids were isolated from the aerial parts of Tabernaemontana divaricata. Alkaloids 1 and 2 are the first vobasinyl-ibogan-type alkaloids possessing a six-membered ring via an ether linkage between C-17 and C-21. All compounds except for 3 were evaluated for their cytotoxicity against five human cancer cell lines; conophylline showed significant bioactivity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cells with IC50 values of 0.17, 0.35, 0.21, 1.02, and 1.49 mu M, respectively.
关键词Iboga Alkaloids Bisindole Alkaloids Apocynaceae Corymbosa
资助信息National Natural Science Foundation of China [81225024, 21172225, 31170334, 21072198]; 973 Program of Ministry of Science and Technology of P. R. China [2009CB522300]; Young Academic and Technical Leader Raising Foundation of Yunnan Province [2010CI049]; XiBuZhiGuang Project of Chinese Academy of Sciences; National Natural Science Foundation of China(81225024; 973 Program of Ministry of Science and Technology of P. R. China(2009CB522300); Young Academic and Technical Leader Raising Foundation of Yunnan Province(2010CI049); XiBuZhiGuang Project of Chinese Academy of Sciences; 21172225; 31170334; 21072198)
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np400130y
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000323630500003
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16711
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China
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Bao, Mei-Fen,Yan, Ju-Ming,Cheng, Gui-Guang,et al. Cytotoxic Indole Alkaloids from Tabernaemontana divaricata[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(8):1406-1412.
APA Bao, Mei-Fen.,Yan, Ju-Ming.,Cheng, Gui-Guang.,Li, Xing-Yao.,Liu, Ya-Ping.,...&Luo, Xiao-Dong.(2013).Cytotoxic Indole Alkaloids from Tabernaemontana divaricata.JOURNAL OF NATURAL PRODUCTS,76(8),1406-1412.
MLA Bao, Mei-Fen,et al."Cytotoxic Indole Alkaloids from Tabernaemontana divaricata".JOURNAL OF NATURAL PRODUCTS 76.8(2013):1406-1412.
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