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Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 19, 页码: 4667-4671
作者:  Wang, Jun-Feng;  Deng, Yi-Hui;  Yang, Sheng-Hui;  Liu, Yan-Qun;  Wang, Yue-Hu;  Pan, Wei-Wei;  Zhou, Xiao-Jiang;  Zhou,XJ (reprint author),Hunan Univ Chinese Med,Coll Pharm,Changsha 410208,Hunan,Peoples R China.;  gale9888@163.com
Adobe PDF(1369Kb)  |  收藏  |  浏览/下载：222/41  |  提交时间：2014/11/25
Zanthoxylum Simulans  Dimeric Lignans  Synovial Cells  Splenocytes  
Isolation and Complete Structural Assignment of Lycopodium Alkaloid Cernupalhine A: Theoretical Prediction and Total Synthesis Validation 期刊论文
ORGANIC LETTERS, 2014, 卷号: 16, 期号: 10, 页码: 2700-2703
作者:  Dong, Liao-Bin;  Wu, Ya-Nan;  Jiang, Shi-Zhi;  Wu, Xing-De;  He, Juan;  Yang, Yu-Rong;  Zhao, Qin-Shi
Adobe PDF(319Kb)  |  收藏  |  浏览/下载：345/55  |  提交时间：2014/06/23
Fawcettimine-related Alkaloids  Alpha  Unified Total Syntheses  Beta-unsaturated Carbonyl-compounds  Palhinhaea-cernua  Unprecedented Skeleton  Helquist Annulation  A-c  Japonicum  (-)-8-deoxyserratinine  (+)-lycoflexine  
Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 8, 页码: 1884-1888
作者:  Yan, Chen;  Huang, Li;  Liu, Hong-Chun;  Chen, Duo-Zhi;  Liu, Hai-Yang;  Li, Xiao-Hui;  Zhang, Yu;  Geng, Mei-Yu;  Chen, Quan;  Hao, Xiao-Jiang
Adobe PDF(1562Kb)  |  收藏  |  浏览/下载：297/45  |  提交时间：2014/06/23
Spiramine Derivative  Bax(-/-)/bak(-/-) Cells  Alpha  Apoptosis  Beta-unsaturated Ketone  Cytotoxicity  
Asymmetric Synthesis of the Tricyclic Core of Calyciphylline A-Type Alkaloids via Intramolecular [3+2] Cycloaddition 期刊论文
ORGANIC LETTERS, 2014, 卷号: 16, 期号: 4, 页码: 1076-1079
作者:  Wang, Lu;  Xu, Chen;  Chen, Li;  Hao, Xiaojiang;  Wang, David Zhigang
Adobe PDF(389Kb)  |  收藏  |  浏览/下载：278/62  |  提交时间：2014/04/09
Beta-hydroxy Ketones  Nitrile Oxide Cycloaddition  Daphniphyllum Alkaloids  Tetracyclic Core  Daphnilactone-b  Ring-system  Construction  Reduction  Delta-2-isoxazolines  Route  
Cytotoxicity of naturally occurring rhamnofolane diterpenes from Jatropha curcas 期刊论文
PHYTOCHEMISTRY, 2013, 卷号: 96, 页码: 265-272
作者:  Liu, Jie-Qing;  Yang, Yuan-Feng;  Li, Xu-Yang;  Liu, En-Qian;  Li, Zhong-Rong;  Zhou, Lin;  Li, Yan;  Qiu, Ming-Hua
Adobe PDF(915Kb)  |  收藏  |  浏览/下载：280/97  |  提交时间：2015/05/14
Jatropha Curcas  Euphorbiaceae  Rhamnofolane Diterpenoids  Cytotoxicity  
Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11 beta-HSD1 inhibitors: Potential impact in diabetes 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 65, 页码: 403-414
作者:  Deng, Xu;  Shen, Yu;  Yang, Jing;  He, Juan;  Zhao, Yu;  Peng, Li-Yan;  Leng, Ying;  Zhao, Qin-Shi
Adobe PDF(1215Kb)  |  收藏  |  浏览/下载：406/152  |  提交时间：2013/10/16
Ent-kaurene Diterpenoids  Structure-activity Relationship Studies  Selective 11 Beta-hsd1 Inhibitors  Urea Derivatives  Diabetes  
Dual-Functional abeo-Taxane Derivatives Destabilizing Microtubule Equilibrium and Inhibiting NF-kappa B Activation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 56, 期号: 11, 页码: 4749-4757
作者:  Zhao, Yu;  Su, Jia;  Goto, Masuo;  Morris-Natschke, Susan L.;  Li, Yan;  Zhao, Qin-Shi;  Yao, Zhu-Jun;  Lee, Kuo-Hsiung
Adobe PDF(531Kb)  |  收藏  |  浏览/下载：311/65  |  提交时间：2013/10/16
Natural-products  Biological-activity  Cancer-therapy  Paclitaxel  Taxol  Resistance  Drugs  Chemotherapy  Parthenolide  Brevifoliol  
Terpene and lignan glycosides from the twigs and leaves of an endangered conifer, Cathaya argyrophylla 期刊论文
PHYTOCHEMISTRY, 2012, 卷号: 83, 页码: 63-69
作者:  He, Wen-Jun;  Fu, Zhao-Hui;  Zeng, Guang-Zhi;  Zhang, Yu-Mei;  Han, Hong-Jin;  Yan, He;  Ji, Chang-Jiu;  Chu, Hong-Biao;  Tan, Ning-Hua
Adobe PDF(312Kb)  |  收藏  |  浏览/下载：744/223  |  提交时间：2013/01/22
Cathaya Argyrophylla  Pinaceae  Labdane Diterpene Glycosides  Lignan Glycosides  Cathargyrosides A-b  
Conosilane A, an Unprecedented Sesquiterpene from the Cultures of Basidiomycete Conocybe siliginea 期刊论文
ORGANIC LETTERS, 2012, 卷号: 14, 期号: 20, 页码: 5382-5384
作者:  Yang, Xiao-Yan;  Feng, Tao;  Li, Zheng-Hui;  Sheng, Yu;  Yin, Xia;  Leng, Ying;  Liu, Ji-Kai
Adobe PDF(205Kb)  |  收藏  |  浏览/下载：388/121  |  提交时间：2013/01/22
Psilocybin  Humans  Fungi  
Chlorantholides A-F, eudesmane-type sesquiterpene lactones from Chloranthus elatior 期刊论文
PHYTOCHEMISTRY, 2012, 卷号: 77, 期号: 77, 页码: 312-317
作者:  Wang, Fei;  Zhou, Dong-Sheng;  Wei, Guo-Zhu;  Ren, Fu-Cai;  Liu, Ji-Kai
Adobe PDF(442Kb)  |  收藏  |  浏览/下载：956/302  |  提交时间：2012/06/07
Chloranthaceae  Chloranthus Elatior  Eudesmanolide  Sesquiterpene  Cd Exciton Chirality Method  Structure Revision