| Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans | |
Wang, Jun-Feng2; Deng, Yi-Hui1,3; Yang, Sheng-Hui1; Liu, Yan-Qun1; Wang, Yue-Hu4 ; Pan, Wei-Wei1; Zhou, Xiao-Jiang1; Zhou,XJ (reprint author),Hunan Univ Chinese Med,Coll Pharm,Changsha 410208,Hunan,Peoples R China.; gale9888@163.com
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| 2014-10-01 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| ISSN | 0960-894X |
| 卷号 | 24期号:19页码:4667-4671 |
| 摘要 | Investigation of the bark of Zanthoxylum simulans afforded six new dimeric lignans zanthpodocarpins C-H (1-6) bearing an unusual alpha,beta-unsaturated ketone group. The new structures of 1-6 were determined by using detailed spectroscopic analysis. All of the isolated compounds were examined for their inhibitory effects against rat joint synovial cell and splenocyte proliferation. Compounds 1-6 showed potent anti-inflammatory activities with IC50 values ranging from 18.6 to 36.1 mu M, and 13.8 to 74.3 mu M. (C) 2014 Elsevier Ltd. All rights reserved. |
| 关键词 | Zanthoxylum Simulans Dimeric Lignans Synovial Cells Splenocytes |
| 学科领域 | Pharmacology & Pharmacy ; Chemistry |
| DOI | 10.1016/j.bmcl.2014.08.042 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000342574600011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18410 |
| 专题 | 资源植物与生物技术所级重点实验室 |
| 通讯作者 | Zhou,XJ (reprint author),Hunan Univ Chinese Med,Coll Pharm,Changsha 410208,Hunan,Peoples R China.; gale9888@163.com |
| 作者单位 | 1.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China 2.Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol,Guand, Guangzhou 510301, Guangdong, Peoples R China 3.Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jun-Feng,Deng, Yi-Hui,Yang, Sheng-Hui,et al. Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(19):4667-4671. |
| APA | Wang, Jun-Feng.,Deng, Yi-Hui.,Yang, Sheng-Hui.,Liu, Yan-Qun.,Wang, Yue-Hu.,...&gale9888@163.com.(2014).Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(19),4667-4671. |
| MLA | Wang, Jun-Feng,et al."Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.19(2014):4667-4671. |
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