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Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans
Wang, Jun-Feng2; Deng, Yi-Hui1,3; Yang, Sheng-Hui1; Liu, Yan-Qun1; Wang, Yue-Hu4; Pan, Wei-Wei1; Zhou, Xiao-Jiang1; Zhou,XJ (reprint author),Hunan Univ Chinese Med,Coll Pharm,Changsha 410208,Hunan,Peoples R China.; gale9888@163.com
2014-10-01
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume24Issue:19Pages:4667-4671
Contribution Rank第四
AbstractInvestigation of the bark of Zanthoxylum simulans afforded six new dimeric lignans zanthpodocarpins C-H (1-6) bearing an unusual alpha,beta-unsaturated ketone group. The new structures of 1-6 were determined by using detailed spectroscopic analysis. All of the isolated compounds were examined for their inhibitory effects against rat joint synovial cell and splenocyte proliferation. Compounds 1-6 showed potent anti-inflammatory activities with IC50 values ranging from 18.6 to 36.1 mu M, and 13.8 to 74.3 mu M. (C) 2014 Elsevier Ltd. All rights reserved.
KeywordZanthoxylum Simulans Dimeric Lignans Synovial Cells Splenocytes
Subject AreaPharmacology & Pharmacy ; Chemistry
DOI10.1016/j.bmcl.2014.08.042
Indexed BySCI ; IC
Language英语
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS SubjectChemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000342574600011
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/18410
Collection资源植物与生物技术所级重点实验室
Corresponding AuthorZhou,XJ (reprint author),Hunan Univ Chinese Med,Coll Pharm,Changsha 410208,Hunan,Peoples R China.; gale9888@163.com
Affiliation1.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China
2.Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol,Guand, Guangzhou 510301, Guangdong, Peoples R China
3.Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jun-Feng,Deng, Yi-Hui,Yang, Sheng-Hui,et al. Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(19):4667-4671.
APA Wang, Jun-Feng.,Deng, Yi-Hui.,Yang, Sheng-Hui.,Liu, Yan-Qun.,Wang, Yue-Hu.,...&gale9888@163.com.(2014).Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(19),4667-4671.
MLA Wang, Jun-Feng,et al."Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.19(2014):4667-4671.
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