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题名: Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans
作者: Wang, Jun-Feng2; Deng, Yi-Hui1, 3; Yang, Sheng-Hui1; Liu, Yan-Qun1; Wang YueHu(王跃虎)4; Pan, Wei-Wei1; Zhou, Xiao-Jiang1
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: Zanthoxylum simulans ; Dimeric lignans ; Synovial cells ; Splenocytes
英文摘要: Investigation of the bark of Zanthoxylum simulans afforded six new dimeric lignans zanthpodocarpins C-H (1-6) bearing an unusual alpha,beta-unsaturated ketone group. The new structures of 1-6 were determined by using detailed spectroscopic analysis. All of the isolated compounds were examined for their inhibitory effects against rat joint synovial cell and splenocyte proliferation. Compounds 1-6 showed potent anti-inflammatory activities with IC50 values ranging from 18.6 to 36.1 mu M, and 13.8 to 74.3 mu M. (C) 2014 Elsevier Ltd. All rights reserved.
出版日期: 2014-10-01
卷号: 24, 期号:19, 页码:4667-4671
DOI标识: 10.1016/j.bmcl.2014.08.042
语种: 英语
ISSN号: 0960-894X
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18410
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China
2.Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol,Guand, Guangzhou 510301, Guangdong, Peoples R China
3.Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

Recommended Citation:
Wang,Jun-Feng;Deng,Yi-Hui;Yang,Sheng-Hui;Liu,Yan-Qun;Wang,Yue-Hu;Pan,Wei-Wei;Zhou,Xiao-Jiang.Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(19):4667-4671
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