Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans
Wang, Jun-Feng2; Deng, Yi-Hui1,3; Yang, Sheng-Hui1; Liu, Yan-Qun1; Wang, Yue-Hu4; Pan, Wei-Wei1; Zhou, Xiao-Jiang1; Zhou,XJ (reprint author),Hunan Univ Chinese Med,Coll Pharm,Changsha 410208,Hunan,Peoples R China.; gale9888@163.com
2014-10-01
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号24期号:19页码:4667-4671
产权排序第四
摘要Investigation of the bark of Zanthoxylum simulans afforded six new dimeric lignans zanthpodocarpins C-H (1-6) bearing an unusual alpha,beta-unsaturated ketone group. The new structures of 1-6 were determined by using detailed spectroscopic analysis. All of the isolated compounds were examined for their inhibitory effects against rat joint synovial cell and splenocyte proliferation. Compounds 1-6 showed potent anti-inflammatory activities with IC50 values ranging from 18.6 to 36.1 mu M, and 13.8 to 74.3 mu M. (C) 2014 Elsevier Ltd. All rights reserved.
关键词Zanthoxylum Simulans Dimeric Lignans Synovial Cells Splenocytes
资助信息National Natural Science Foundation of China [31170336]; Hunan Provincial Natural Science Foundation, China [14JJ2108]; Hunan Province University Innovation Platform Open Foundation, China [12K085]
学科领域Pharmacology & Pharmacy ; Chemistry
DOI10.1016/j.bmcl.2014.08.042
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000342574600011
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18410
专题资源植物与生物技术所级重点实验室
通讯作者Zhou,XJ (reprint author),Hunan Univ Chinese Med,Coll Pharm,Changsha 410208,Hunan,Peoples R China.; gale9888@163.com
作者单位1.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China
2.Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol,Guand, Guangzhou 510301, Guangdong, Peoples R China
3.Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
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Wang, Jun-Feng,Deng, Yi-Hui,Yang, Sheng-Hui,et al. Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(19):4667-4671.
APA Wang, Jun-Feng.,Deng, Yi-Hui.,Yang, Sheng-Hui.,Liu, Yan-Qun.,Wang, Yue-Hu.,...&gale9888@163.com.(2014).Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(19),4667-4671.
MLA Wang, Jun-Feng,et al."Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.19(2014):4667-4671.
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