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An Approach for the Synthesis of Pyrazolo[1,5-a]pyrimidines via Cu(II)-Catalyzed [3+3] Annulation of Saturated Ketones with Aminopyrazoles 期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 86, 期号: 18, 页码: 12762-12771
作者:  Ren,Jian;  Ding,Shihua;  Li,Xiaonian;  Bi,Ran;  Zhao,Qinshi
浏览  |  Adobe PDF(1469Kb)  |  收藏  |  浏览/下载：82/18  |  提交时间：2022/04/02
BIOLOGICAL EVALUATION  REGIOSELECTIVE SYNTHESIS  CASCADE REACTIONS  FUNCTIONALIZATION  DEHYDROGENATION  DISCOVERY  POTENT  BOND  SAR  
Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 21, 页码: 9053-9066
作者:  Shao, Li-Dong;  Su, Jia;  Ye, Baixin;  Liu, Jiang-Xin;  Zuo, Zhi-Li;  Li, Yan;  Wang, Yue-Ying;  Xia, Chengfeng;  Zhao, Qin-Shi
浏览  |  Adobe PDF(5724Kb)  |  收藏  |  浏览/下载：376/42  |  提交时间：2017/12/18
Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 41, 页码: 66689-66699
作者:  Zhang, Ruowen;  Che, Xun;  Zhang, Jingjie;  Li, Yang;  Li, Jingxia;  Deng, Xu;  Zhu, Junlan;  Jin, Honglei;  Zhao, Qinshi;  Huang, Chuanshu
Adobe PDF(9106Kb)  |  收藏  |  浏览/下载：197/45  |  提交时间：2017/01/05
Chel a  Human Bladder Cancer  Apoptosis  Phlpp2  C-jun  
Natural Product Vibsanin A Induces Differentiation of Myeloid Leukemia Cells through PKC Activation 期刊论文
CANCER RESEARCH, 2016, 卷号: 76, 期号: 9, 页码: 2698-2709
作者:  Yu, Zu-Yin;  Xiao, He;  Wang, Li-Mei;  Shen, Xing;  Jing, Yu;  Wang, Lin;  Sun, Wen-Feng;  Zhang, Yan-Feng;  Cui, Yu;  Shan, Ya-Jun;  Zhou, Wen-Bing;  Xing, Shuang;  Xiong, Guo-Lin;  Liu, Xiao-Lan;  Dong, Bo;  Feng, Jian-Nan;  Wang, Li-Sheng;  Luo, Qing-Liang;  Zhao, Qin-Shi;  Cong, Yu-Wen
Adobe PDF(1368Kb)  |  收藏  |  浏览/下载：284/95  |  提交时间：2016/08/22
Natural product vibsanine A induces differentiation of myeloid leukemia cells through PKC activation 期刊论文
Cancer Research, 2016, 期号: 1, 页码: 1
作者:  Zhao QS(赵勤实)
Adobe PDF(1368Kb)  |  收藏  |  浏览/下载：135/44  |  提交时间：2017/02/28
Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis 期刊论文
JOURNAL OF IMMUNOLOGY, 2015, 卷号: 194, 期号: 9, 页码: 4489-4497
作者:  Ye, Bai-Xin;  Deng, Xu;  Shao, Li-Dong;  Lu, Ying;  Xiao, Run;  Liu, Yi-Jie;  Jin, Yi;  Xie, Yin-Yin;  Zhao, Yan;  Luo, Liu-Fei;  Ma, Shun;  Gao, Ming;  Zhang, Lian-Ru;  He, Juan;  Zhang, Wei-Na;  Chen, Yi;  Xia, Cheng-Feng;  Deng, Min;  Liu, Ting-Xi;  Zhao, Qin-Shi;  Chen, Sai-Juan;  Chen, Zhu;  Chen,Z (reprint author),Shanghai Jiao Tong Univ,RuiJin Hosp,Sch Med,197 Rui Jin Rd 2,Shanghai 200025,Peoples R China.;  qinshizhao@mail.kib.ac.cn;  sjchen@stn.sh.cn;  zchen@stn.sh.cn
Adobe PDF(1516Kb)  |  收藏  |  浏览/下载：272/43  |  提交时间：2015/07/20
Crucial Role of c-Jun Phosphorylation at Ser63/73 Mediated by PHLPP Protein Degradation in the Cheliensisin A Inhibition of Cell Transformation 期刊论文
CANCER PREVENTION RESEARCH, 2014, 卷号: 7, 期号: 12, 页码: 1270-1281
作者:  Zhu, Junlan;  Zhang, Jingjie;  Huang, Haishan;  Li, Jingxia;  Yu, Yonghui;  Jin, Honglei;  Li, Yang;  Deng, Xu;  Gao, Jimin;  Zhao, Qinshi;  Huang, Chuanshu;  Huang,CS (reprint author),NYU,Sch Med,Nelson Inst Environm Med,57 Old Forge Rd,Tuxedo Pk,NY 10987 USA.
浏览  |  Adobe PDF(3644Kb)  |  收藏  |  浏览/下载：199/38  |  提交时间：2015/01/20
Naturally Occurring Substances  Magnetic-resonance Spectroscopy  Stem-bark  Melodinus-henryi  Conformational-analysis  (+)-scholarisine  Mechanism  Leaves  Seeds  Camptothecin  Indole Alkaloids  Cytotoxicity  Absolute Configuration  Vinca Major  
Identification and validation of p50 as the cellular target of eriocalyxin B 期刊论文
ONCOTARGET, 2014, 卷号: 5, 期号: 22, 页码: 11354-11364
作者:  Kong, Ling-Mei;  Deng, Xu;  Zuo, Zhi-Li;  Sun, Han-Dong;  Zhao, Qin-Shi;  Li, Yan
Adobe PDF(3014Kb)  |  收藏  |  浏览/下载：280/71  |  提交时间：2015/06/17
Erib  Activity-based Probes  P50  Nf-kappa b Signaling  Apoptosis  
New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum 期刊论文
TETRAHEDRON, 2014, 卷号: 70, 期号: 46, 页码: 8893-8899
作者:  Li, Yan-Hong;  Li, Hong-Mei;  Li, Yan;  He, Juan;  Deng, Xu;  Peng, Li-Yan;  Gao, Ling-Huan;  Zhao, Qin-Shi;  Li, Rong-Tao;  Wu, Xing-De;  Li,RT (reprint author),Kunming Univ Sci & Technol,Fac Life Sci & Technol,Kunming 650500,Yunnan,Peoples R China.;  rongtaolikm@gmail.com;  wuxingde@mail.kib.ac.cn
Adobe PDF(673Kb)  |  收藏  |  浏览/下载：262/71  |  提交时间：2015/01/20
Sinomenium Acutum  Bistetrahydroisoquinoline Alkaloid  Acid Hydrolysis  Cytotoxicity  Anti-inflammatory Activity  
Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity 期刊论文
MOLECULES, 2014, 卷号: 19, 期号: 3, 页码: 3345-3355
作者:  Zhao, Dan-Dan;  Zhao, Qin-Shi;  Liu, Li;  Chen, Zhong-Qin;  Zeng, Wei-Min;  Lei, Hong;  Zhang, Yan-Long
Adobe PDF(408Kb)  |  收藏  |  浏览/下载：265/56  |  提交时间：2014/06/23
Dryopteris Fragrans (L.) Schott  Compounds  Mtt  Cytotoxic Activity