Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity
Zhao, Dan-Dan1; Zhao, Qin-Shi2; Liu, Li1,2; Chen, Zhong-Qin1; Zeng, Wei-Min1; Lei, Hong1; Zhang, Yan-Long1
2014-03-01
发表期刊MOLECULES
ISSN1420-3049
卷号19期号:3页码:3345-3355
摘要One new coumarin, dryofracoumarin A (1), and eight known compounds 2-9 were isolated from Dryopteris fragrans (L.) Schott. Their structures were established on the basis of extensive spectroscopic data analyses and comparison with reported spectroscopic data. The new compound 1 was determined to be 8-hydroxyl-4-isopropyl-7-methyl-6-methyl-2H-benzopyran-2-one. Two dimers, trans-and cis-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl] cyclohex-1-ene (compounds 8 and 9), were isolated from the Dryopteris genus for the first time. The other six were esculetin (2), isoscopoletin (3), methylphlorbutyrophenone (4), aspidinol (5), albicanol (6) and (E)-4-(3,4-dimethoxyphenyl) but-3-en-1-ol (7). All compounds were evaluated for their cytotoxic effects by the MTT assay. Compounds 2, 3, 8 and 9 showed significantly cytotoxic effects against three cell lines (A549, MCF7 and HepG2), 1 and 5 against two cell lines (A549 and MCF7), and 6 against one cell line (MCF7). Their IC50 values ranged between 2.73 +/- 0.86 +/- mu M and 24.14 +/- 3.12 mu M. These active compounds might be promising lead compounds for the treatment of cancer.
关键词Dryopteris Fragrans (L.) Schott Compounds Mtt Cytotoxic Activity
资助信息Natural Science Foundation Project, Heilongjiang Province, China [D201023]; Science Research Project of Educational Commission, Heilongjiang Province, China [11551384]; International Scientific and Technological Cooperation Project of Heilongjiang Province, China [WB08B08]
学科领域Chemistry
DOI10.3390/molecules19033345
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000335826800040
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18115
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Heilongjiang Univ, Coll Life Sci, Key Lab Mol Biol Heilongjiang Prov, Harbin 150080, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Phytochem & Plant Resources West China, Kunming 650204, Peoples R China
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Zhao, Dan-Dan,Zhao, Qin-Shi,Liu, Li,et al. Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity[J]. MOLECULES,2014,19(3):3345-3355.
APA Zhao, Dan-Dan.,Zhao, Qin-Shi.,Liu, Li.,Chen, Zhong-Qin.,Zeng, Wei-Min.,...&Zhang, Yan-Long.(2014).Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity.MOLECULES,19(3),3345-3355.
MLA Zhao, Dan-Dan,et al."Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity".MOLECULES 19.3(2014):3345-3355.
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