| Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity | |
Zhao, Dan-Dan1; Zhao, Qin-Shi2 ; Liu, Li1,2; Chen, Zhong-Qin1; Zeng, Wei-Min1; Lei, Hong1; Zhang, Yan-Long1
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| 通讯作者 | Zhang,YL (reprint author),Heilongjiang Univ,Coll Life Sci,Key Lab Mol Biol Heilongjiang Prov,Harbin 150080,Peoples R China. ; zhaodandan@hlju.edu.cn ; qinshizhao@mail.kib.ac.cn ; liliuhlju@gmail.com ; zqchenhd@163.com ; wmzenghd@163.com ; hleihd@163.com ; YLZhangHd@163.com |
| 2014-03-01 | |
| 发表期刊 | MOLECULES
 |
| ISSN | 1420-3049 |
| 卷号 | 19期号:3页码:3345-3355 |
| 摘要 | One new coumarin, dryofracoumarin A (1), and eight known compounds 2-9 were isolated from Dryopteris fragrans (L.) Schott. Their structures were established on the basis of extensive spectroscopic data analyses and comparison with reported spectroscopic data. The new compound 1 was determined to be 8-hydroxyl-4-isopropyl-7-methyl-6-methyl-2H-benzopyran-2-one. Two dimers, trans-and cis-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl] cyclohex-1-ene (compounds 8 and 9), were isolated from the Dryopteris genus for the first time. The other six were esculetin (2), isoscopoletin (3), methylphlorbutyrophenone (4), aspidinol (5), albicanol (6) and (E)-4-(3,4-dimethoxyphenyl) but-3-en-1-ol (7). All compounds were evaluated for their cytotoxic effects by the MTT assay. Compounds 2, 3, 8 and 9 showed significantly cytotoxic effects against three cell lines (A549, MCF7 and HepG2), 1 and 5 against two cell lines (A549 and MCF7), and 6 against one cell line (MCF7). Their IC50 values ranged between 2.73 +/- 0.86 +/- mu M and 24.14 +/- 3.12 mu M. These active compounds might be promising lead compounds for the treatment of cancer. |
| 关键词 | Dryopteris Fragrans (L.) Schott Compounds Mtt Cytotoxic Activity |
| 学科领域 | Chemistry |
| DOI | 10.3390/molecules19033345 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000335826800040 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18115 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Heilongjiang Univ, Coll Life Sci, Key Lab Mol Biol Heilongjiang Prov, Harbin 150080, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Phytochem & Plant Resources West China, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Dan-Dan,Zhao, Qin-Shi,Liu, Li,et al. Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity[J]. MOLECULES,2014,19(3):3345-3355. |
| APA | Zhao, Dan-Dan.,Zhao, Qin-Shi.,Liu, Li.,Chen, Zhong-Qin.,Zeng, Wei-Min.,...&Zhang, Yan-Long.(2014).Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity.MOLECULES,19(3),3345-3355. |
| MLA | Zhao, Dan-Dan,et al."Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity".MOLECULES 19.3(2014):3345-3355. |
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