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题名: Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity
作者: Zhao, Dan-Dan1; null(赵勤实)2; Liu, Li1, 2; Chen, Zhong-Qin1; Zeng, Wei-Min1; Lei, Hong1; Zhang, Yan-Long1
刊名: MOLECULES
关键词: Dryopteris fragrans (L.) Schott ; compounds ; MTT ; cytotoxic activity
英文摘要: One new coumarin, dryofracoumarin A (1), and eight known compounds 2-9 were isolated from Dryopteris fragrans (L.) Schott. Their structures were established on the basis of extensive spectroscopic data analyses and comparison with reported spectroscopic data. The new compound 1 was determined to be 8-hydroxyl-4-isopropyl-7-methyl-6-methyl-2H-benzopyran-2-one. Two dimers, trans-and cis-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl] cyclohex-1-ene (compounds 8 and 9), were isolated from the Dryopteris genus for the first time. The other six were esculetin (2), isoscopoletin (3), methylphlorbutyrophenone (4), aspidinol (5), albicanol (6) and (E)-4-(3,4-dimethoxyphenyl) but-3-en-1-ol (7). All compounds were evaluated for their cytotoxic effects by the MTT assay. Compounds 2, 3, 8 and 9 showed significantly cytotoxic effects against three cell lines (A549, MCF7 and HepG2), 1 and 5 against two cell lines (A549 and MCF7), and 6 against one cell line (MCF7). Their IC50 values ranged between 2.73 +/- 0.86 +/- mu M and 24.14 +/- 3.12 mu M. These active compounds might be promising lead compounds for the treatment of cancer.
出版日期: 2014-03-01
卷号: 19, 期号:3, 页码:3345-3355
语种: 英语
收录类别: SCI
学科分类: Chemistry
ISSN号: 1420-3049
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18115
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Heilongjiang Univ, Coll Life Sci, Key Lab Mol Biol Heilongjiang Prov, Harbin 150080, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Phytochem & Plant Resources West China, Kunming 650204, Peoples R China

Recommended Citation:
Zhao,Dan-Dan;Zhao,Qin-Shi;Liu,Li;Chen,Zhong-Qin;Zeng,Wei-Min;Lei,Hong;Zhang,Yan-Long.Compounds from Dryopteris Fragrans (L.) Schott with Cytotoxic Activity,MOLECULES,2014,19(3):3345-3355
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