| New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum | |
Li, Yan-Hong1,2; Li, Hong-Mei1; Li, Yan2 ; He, Juan2; Deng, Xu2; Peng, Li-Yan2; Gao, Ling-Huan1; Zhao, Qin-Shi2; Li, Rong-Tao1; Wu, Xing-De2; Li,RT (reprint author),Kunming Univ Sci & Technol,Fac Life Sci & Technol,Kunming 650500,Yunnan,Peoples R China.; rongtaolikm@gmail.com; wuxingde@mail.kib.ac.cn
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| 2014-11-18 | |
| 发表期刊 | TETRAHEDRON
 |
| ISSN | 0040-4020 |
| 卷号 | 70期号:46页码:8893-8899 |
| 摘要 | Phytochemical investigation on the rhizomes of Sinomenium acutum led to the isolation of new alkaloids sinomacutines A E (1-5), and cephalonine-2-O-beta-n-glucopyranoside (6), along with known tetrahydroisoquinoline alkaloids (7-9). Among them, sinomacutines A C were new bistetrahydroisoquinoline alkaloids with morphinane-proaporphine and morphinane-benzyltetrahydroisoquinoline types, and coupled with unique C-CH2-N unit. Their structures with absolute configuration were elucidated on the basis of 1D and 2D NMR, and ECD spectra analysis. The new compounds were evaluated for their anti-inflammatory and cytotoxic activities, and sallisonine B (2) showed moderate ability to inhibit NO production of LPS-stimulated RAW264.7 macrophages, as well as sallisonine A (1) showed weak inhibitory effects against five cancer cell lines. (C) 2014 Elsevier Ltd. All rights reserved. |
| 关键词 | Sinomenium Acutum Bistetrahydroisoquinoline Alkaloid Acid Hydrolysis Cytotoxicity Anti-inflammatory Activity |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1016/j.tet.2014.09.088 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000344204700013 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18465 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Li,RT (reprint author),Kunming Univ Sci & Technol,Fac Life Sci & Technol,Kunming 650500,Yunnan,Peoples R China.; rongtaolikm@gmail.com; wuxingde@mail.kib.ac.cn |
| 作者单位 | 1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yan-Hong,Li, Hong-Mei,Li, Yan,et al. New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum[J]. TETRAHEDRON,2014,70(46):8893-8899. |
| APA | Li, Yan-Hong.,Li, Hong-Mei.,Li, Yan.,He, Juan.,Deng, Xu.,...&wuxingde@mail.kib.ac.cn.(2014).New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum.TETRAHEDRON,70(46),8893-8899. |
| MLA | Li, Yan-Hong,et al."New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum".TETRAHEDRON 70.46(2014):8893-8899. |
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