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题名: New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum
作者: Li, Yan-Hong1, 2; Li, Hong-Mei1; null(李艳)2; He, Juan2; Deng, Xu2; Peng, Li-Yan2; Gao, Ling-Huan1; Zhao, Qin-Shi2; Li, Rong-Tao1; Wu, Xing-De2
刊名: TETRAHEDRON
出版日期: 2014-11-18
卷号: 70, 期号:46, 页码:8893-8899
关键词: Sinomenium acutum ; Bistetrahydroisoquinoline alkaloid ; Acid hydrolysis ; Cytotoxicity ; Anti-inflammatory activity
学科分类: Chemistry, Organic
DOI: 10.1016/j.tet.2014.09.088
通讯作者: Li,RT (reprint author),Kunming Univ Sci & Technol,Fac Life Sci & Technol,Kunming 650500,Yunnan,Peoples R China. ; rongtaolikm@gmail.com ; wuxingde@mail.kib.ac.cn
文章类型: Article
英文摘要: Phytochemical investigation on the rhizomes of Sinomenium acutum led to the isolation of new alkaloids sinomacutines A E (1-5), and cephalonine-2-O-beta-n-glucopyranoside (6), along with known tetrahydroisoquinoline alkaloids (7-9). Among them, sinomacutines A C were new bistetrahydroisoquinoline alkaloids with morphinane-proaporphine and morphinane-benzyltetrahydroisoquinoline types, and coupled with unique C-CH2-N unit. Their structures with absolute configuration were elucidated on the basis of 1D and 2D NMR, and ECD spectra analysis. The new compounds were evaluated for their anti-inflammatory and cytotoxic activities, and sallisonine B (2) showed moderate ability to inhibit NO production of LPS-stimulated RAW264.7 macrophages, as well as sallisonine A (1) showed weak inhibitory effects against five cancer cell lines. (C) 2014 Elsevier Ltd. All rights reserved.
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: STEPHANIA-CEPHARANTHA ; MORPHINANE
收录类别: SCI ; IC
项目资助者: National Natural Science Foundation of China [81360457] ; Natural Science Foundation of Yunnan Province [2012FB099]
语种: 英语
WOS记录号: WOS:000344204700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18465
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Li,Yan-Hong;Li,Hong-Mei;Li,Yan;He,Juan;Deng,Xu;Peng,Li-Yan;Gao,Ling-Huan;Zhao,Qin-Shi;Li,Rong-Tao;Wu,Xing-De.New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum,TETRAHEDRON,2014,41(6):503-507
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文件名: Li-2014-New alkaloids sinomacutines A-E, and c.pdf
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