New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum
Li, Yan-Hong1,2; Li, Hong-Mei1; Li, Yan2; He, Juan2; Deng, Xu2; Peng, Li-Yan2; Gao, Ling-Huan1; Zhao, Qin-Shi2; Li, Rong-Tao1; Wu, Xing-De2; Li,RT (reprint author),Kunming Univ Sci & Technol,Fac Life Sci & Technol,Kunming 650500,Yunnan,Peoples R China.; rongtaolikm@gmail.com; wuxingde@mail.kib.ac.cn
2014-11-18
发表期刊TETRAHEDRON
ISSN0040-4020
卷号70期号:46页码:8893-8899
摘要Phytochemical investigation on the rhizomes of Sinomenium acutum led to the isolation of new alkaloids sinomacutines A E (1-5), and cephalonine-2-O-beta-n-glucopyranoside (6), along with known tetrahydroisoquinoline alkaloids (7-9). Among them, sinomacutines A C were new bistetrahydroisoquinoline alkaloids with morphinane-proaporphine and morphinane-benzyltetrahydroisoquinoline types, and coupled with unique C-CH2-N unit. Their structures with absolute configuration were elucidated on the basis of 1D and 2D NMR, and ECD spectra analysis. The new compounds were evaluated for their anti-inflammatory and cytotoxic activities, and sallisonine B (2) showed moderate ability to inhibit NO production of LPS-stimulated RAW264.7 macrophages, as well as sallisonine A (1) showed weak inhibitory effects against five cancer cell lines. (C) 2014 Elsevier Ltd. All rights reserved.
关键词Sinomenium Acutum Bistetrahydroisoquinoline Alkaloid Acid Hydrolysis Cytotoxicity Anti-inflammatory Activity
资助信息National Natural Science Foundation of China [81360457]; National Natural Science Foundation of China [81360457]; Natural Science Foundation of Yunnan Province [2012FB099]; Natural Science Foundation of Yunnan Province [2012FB099]
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18465
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Li,RT (reprint author),Kunming Univ Sci & Technol,Fac Life Sci & Technol,Kunming 650500,Yunnan,Peoples R China.; rongtaolikm@gmail.com; wuxingde@mail.kib.ac.cn
作者单位1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
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Li, Yan-Hong,Li, Hong-Mei,Li, Yan,et al. New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum[J]. TETRAHEDRON,2014,70(46):8893-8899.
APA Li, Yan-Hong.,Li, Hong-Mei.,Li, Yan.,He, Juan.,Deng, Xu.,...&wuxingde@mail.kib.ac.cn.(2014).New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum.TETRAHEDRON,70(46),8893-8899.
MLA Li, Yan-Hong,et al."New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum".TETRAHEDRON 70.46(2014):8893-8899.
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