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Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization 期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 7, 页码: 10
作者:  Zhang, Yu;  Goto, Masuo;  Oda, Akifumi;  Hsu, Pei-Ling;  Guo, Ling-Li;  Fu, Yan-Hui;  Morris-Natschke, Susan L.;  Hamel, Ernest;  Lee, Kuo-Hsiung;  Hao, Xiao-Jiang
Adobe PDF(3129Kb)  |  收藏  |  浏览/下载：213/23  |  提交时间：2019/07/29
aspidosperma-type  monoterpenoid indole alkaloids  antiproliferative activity  tubulin inhibitor  Bousigonia mekongensis  
Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 84, 页码: 285-294
作者:  Chen, Duo-zhi;  Yang, Bi-juan;  He, Xiao-li;  Fan, Shi-rui;  Cai, Jie-yun;  Jing, Chen-xu;  Zhang, Heng;  Zhang, Yu;  Li, Lin;  Hao, Xiao-jiang
Adobe PDF(3047Kb)  |  收藏  |  浏览/下载：312/37  |  提交时间：2019/03/18
Wnt/beta-catenin signalling pathway agonist  Phenanthridine derivatives  Structural optimization  Structure-activity relationships (SARs)  
Synthesis of novel guttiferone E and xanthochymol derivatives with cytotoxicities by inducing cell apoptosis and arresting the cell cycle phase 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 162, 页码: 765-780
作者:  Lin, Xin;  Tian, Dongsong;  Fu, Yanhui;  Li, Yanan;  Huang, Liejun;  Gu, Wei;  Song, Jialei;  Li, Yanmei;  Ben-David, Yaacov;  Wen, Min;  Yuan, Chunmao;  Hao, Xiaojiang
Adobe PDF(2607Kb)  |  收藏  |  浏览/下载：280/47  |  提交时间：2019/03/18
Polycyclic polyprenylated acylphloroglucinol  Chemical transformation  Cytotoxicity  Cell apoptosis  Cell cycle arrest  
Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/beta-catenin transcriptional activity 期刊论文
CELL DISCOVERY, 2017, 卷号: 3, 页码: 17003
作者:  He, Xiaoli;  Zhang, Wenjuan;  Yan, Chen;  Nie, Fen;  Li, Chen;  Liu, Xiaofen;  Fei, Cong;  Li, Shengdi;  Song, Xiaomin;  Jia, Yingying;  Zeng, Rong;  Wu, Dianqing;  Pan, Weijun;  Hao, Xiaojiang;  Li, Lin
浏览  |  Adobe PDF(3775Kb)  |  收藏  |  浏览/下载：143/37  |  提交时间：2017/12/18
Carf  Chemical Biology  Nc043  Small Molecule  Wnt Signaling  
Garmultins A-G, Biogenetically Related Polycyclic Acylphloroglucinols from Garcinia multiflora 期刊论文
ORGANIC LETTERS, 2016, 卷号: 18, 期号: 22, 页码: 5904-5907
作者:  Tian, Dong Song;  Yi, Ping;  Xia, Lei;  Xiao, Xin;  Fan, Yi Min;  Gu, Wei;  Huang, Lie Jun;  Ben-David, Yaacov;  Di, Ying Tong;  Yuan, Chun Mao;  Hao, Xiao Jiang
Adobe PDF(1168Kb)  |  收藏  |  浏览/下载：357/71  |  提交时间：2017/01/05
Protein kinase C controls lysosome biogenesis independently of mTORC1 期刊论文
NATURE CELL BIOLOGY, 2016, 卷号: 18, 期号: 10, 页码: 1065-1077
作者:  Li, Yang;  Xu, Meng;  Ding, Xiao;  Yan, Chen;  Song, Zhiqin;  Chen, Lianwan;  Huang, Xiahe;  Wang, Xin;  Jian, Youli;  Tang, Guihua;  Tang, Changyong;  Di, Yingtong;  Mu, Shuzhen;  Liu, Xuezhao;  Liu, Kai;  Li, Ting;  Wang, Yingchun;  Miao, Long;  Guo, Weixiang;  Hao, Xiaojiang;  Yang, Chonglin
Adobe PDF(4637Kb)  |  收藏  |  浏览/下载：548/149  |  提交时间：2016/12/21
Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction 期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 8, 页码: e73527
作者:  Hu, Rongkuan;  Yan, Huan;  Hao, Xiaojiang;  Liu, Haiyang;  Wu, Jiarui
Adobe PDF(1041Kb)  |  收藏  |  浏览/下载：553/75  |  提交时间：2013/10/16
Activated Protein-kinase  Fatty-acid Oxidation  Respiratory Complex-i  Insulin-resistance  Malonyl-coa  Signaling Pathways  Glucose-uptake  L6 Myotubes  Hepg2 Cells  Metformin  
The endoperoxide ascaridol shows strong differential cytotoxicity in nucleotide excision repair-deficient cells 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2012, 卷号: 259, 期号: 3, 页码: 302-310
作者:  Abbasi, Rashda;  Efferth, Thomas;  Kuhmann, Christine;  Opatz, Till;  Hao, Xiaojiang;  Popanda, Odilia;  Schmezer, Peter
Adobe PDF(738Kb)  |  收藏  |  浏览/下载：461/160  |  提交时间：2012/06/07
Cancer Therapy  Synthetic Lethal  Traditional Chinese Medicine  Xpc  Ercc6  Csb  
Natural Diterpenoid Compound Elevates Expression of Bim Protein, Which Interacts with Antiapoptotic Protein Bcl-2, Converting It to Proapoptotic Bax-like Molecule 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 卷号: 287, 期号: 2, 页码: 1054-1065
作者:  Zhao, Lixia;  He, Feng;  Liu, Haiyang;  Zhu, Yushan;  Tian, Weili;  Gao, Ping;  He, Hongping;  Yue, Wen;  Lei, Xiaobo;  Ni, Biyun;  Wang, Xiaohui;  Jin, Haijing;  Hao, Xiaojiang;  Lin, Jialing;  Chen, Quan
Adobe PDF(2908Kb)  |  收藏  |  浏览/下载：198/43  |  提交时间：2015/06/17
Trichiliton A, a Novel Limonoid from Trichilia connaroides 期刊论文
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2010, 期号: 7, 页码: 1381-1387
作者:  Fang, Xin;  Di, Yingtong;  Geng, Zhaoliang;  Tan, Chenjian;  Guo, Jie;  Ning, Jing;  Hao, Xiaojiang
Adobe PDF(552Kb)  |  收藏  |  浏览/下载：261/80  |  提交时间：2012/03/21
Terpenoids  Natural Products  Structure Elucidation  Biosynthesis  Reaction Mechanisms