Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction

	Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction
	Hu, Rongkuan 1,2; Yan, Huan 3; Hao, Xiaojiang3 ; Liu, Haiyang3 ; Wu, Jiarui 1,2,4,5
通讯作者	Liu, HY (reprint author), Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China. ; haiyangliu@mail.kib.ac.cn ; wujr@sibs.ac.cn
	2013-08-14
发表期刊	PLOS ONE
ISSN	1932-6203
卷号	8 期号:8 页码:e73527
摘要	This study is the first to demonstrate that shizukaol D, a natural compound isolated from Chloranthus japonicus, can activate AMP-activated protein kinase (AMPK), a key sensor and regulator of intracellular energy metabolism, leading to a decrease in triglyceride and cholesterol levels in HepG2 cells. Furthermore, we found that shizukaol D induces mitochondrial dysfunction by depolarizing the mitochondrial membrane and suppressing energy production, which may result in AMPK activation. Our results provide a possible link between mitochondrial dysfunction and AMPK activation and suggest that shizukaol D might be used to treat metabolic syndrome.
关键词	Activated Protein-kinase Fatty-acid Oxidation Respiratory Complex-i Insulin-resistance Malonyl-coa Signaling Pathways Glucose-uptake L6 Myotubes Hepg2 Cells Metformin
学科领域	Multidisciplinary Sciences
收录类别	SCI
语种	英语
WOS记录号	WOS:000323221500147
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/16703
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China 2.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai, Peoples R China 5.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Hu, Rongkuan,Yan, Huan,Hao, Xiaojiang,et al. Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction[J]. PLOS ONE,2013,8(8):e73527.
APA	Hu, Rongkuan,Yan, Huan,Hao, Xiaojiang,Liu, Haiyang,&Wu, Jiarui.(2013).Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction.PLOS ONE,8(8),e73527.
MLA	Hu, Rongkuan,et al."Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction".PLOS ONE 8.8(2013):e73527.

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