Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction
Hu, Rongkuan1,2; Yan, Huan3; Hao, Xiaojiang3; Liu, Haiyang3; Wu, Jiarui1,2,4,5
Corresponding AuthorLiu, HY (reprint author), Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China. ; haiyangliu@mail.kib.ac.cn ; wujr@sibs.ac.cn
2013-08-14
Source PublicationPLOS ONE
ISSN1932-6203
Volume8Issue:8Pages:e73527
AbstractThis study is the first to demonstrate that shizukaol D, a natural compound isolated from Chloranthus japonicus, can activate AMP-activated protein kinase (AMPK), a key sensor and regulator of intracellular energy metabolism, leading to a decrease in triglyceride and cholesterol levels in HepG2 cells. Furthermore, we found that shizukaol D induces mitochondrial dysfunction by depolarizing the mitochondrial membrane and suppressing energy production, which may result in AMPK activation. Our results provide a possible link between mitochondrial dysfunction and AMPK activation and suggest that shizukaol D might be used to treat metabolic syndrome.
KeywordActivated Protein-kinase Fatty-acid Oxidation Respiratory Complex-i Insulin-resistance Malonyl-coa Signaling Pathways Glucose-uptake L6 Myotubes Hepg2 Cells Metformin
Subject AreaMultidisciplinary Sciences
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000323221500147
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16703
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
2.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai, Peoples R China
5.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Hu, Rongkuan,Yan, Huan,Hao, Xiaojiang,et al. Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction[J]. PLOS ONE,2013,8(8):e73527.
APA Hu, Rongkuan,Yan, Huan,Hao, Xiaojiang,Liu, Haiyang,&Wu, Jiarui.(2013).Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction.PLOS ONE,8(8),e73527.
MLA Hu, Rongkuan,et al."Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction".PLOS ONE 8.8(2013):e73527.
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