Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction
Hu, Rongkuan1,2; Yan, Huan3; Hao, Xiaojiang3; Liu, Haiyang3; Wu, Jiarui1,2,4,5
2013-08-14
发表期刊PLOS ONE
ISSN1932-6203
卷号8期号:8页码:e73527
摘要This study is the first to demonstrate that shizukaol D, a natural compound isolated from Chloranthus japonicus, can activate AMP-activated protein kinase (AMPK), a key sensor and regulator of intracellular energy metabolism, leading to a decrease in triglyceride and cholesterol levels in HepG2 cells. Furthermore, we found that shizukaol D induces mitochondrial dysfunction by depolarizing the mitochondrial membrane and suppressing energy production, which may result in AMPK activation. Our results provide a possible link between mitochondrial dysfunction and AMPK activation and suggest that shizukaol D might be used to treat metabolic syndrome.
关键词Activated Protein-kinase Fatty-acid Oxidation Respiratory Complex-i Insulin-resistance Malonyl-coa Signaling Pathways Glucose-uptake L6 Myotubes Hepg2 Cells Metformin
资助信息Ministry of Science and Technology [2010CB912102, 2011CB910200]; National Natural Science Foundation of China [31130034]; Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-EW-Q-10]
学科领域Multidisciplinary Sciences
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000323221500147
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16703
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
2.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai, Peoples R China
5.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai, Peoples R China
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Hu, Rongkuan,Yan, Huan,Hao, Xiaojiang,et al. Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction[J]. PLOS ONE,2013,8(8):e73527.
APA Hu, Rongkuan,Yan, Huan,Hao, Xiaojiang,Liu, Haiyang,&Wu, Jiarui.(2013).Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction.PLOS ONE,8(8),e73527.
MLA Hu, Rongkuan,et al."Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction".PLOS ONE 8.8(2013):e73527.
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