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四种高含量天然产物的化学及生物功能研究 学位论文
, 2021
作者:  周元飞
Adobe PDF(13409Kb)  |  收藏  |  浏览/下载：19/0  |  提交时间：2024/03/20
菲啶类抗PEDV与SARS-CoV-2的活性化合物设计与作用机制研究 学位论文
, 2021
作者:  王宜挺
Adobe PDF(7827Kb)  |  收藏  |  浏览/下载：16/0  |  提交时间：2024/03/20
AmAT19, an acetyltransferase from Astragalus membranaceus, catalyses specific 6 alpha-OH acetylation for tetracyclic triterpenes and steroids 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2021, 卷号: 19, 期号: 33, 页码: 7186-7189
作者:  Wang,Linlin;  Chen,Kuan;  Wang,Zilong;  Yi,Yang;  Zhang,Meng;  Hasan,Aobulikasimu;  Kuang,Yi;  Shaker,Sharpkate;  Yu,Rong;  Wang,Haotian;  Liu,Haiyang;  Ye,Min;  Qiao,Xue
收藏  |  浏览/下载：73/0  |  提交时间：2022/04/02
ACYLATION  ACYLTRANSFERASE  CYCLOASTRAGENOL  BAHD  
1,10/1,11-Cyclization catalyzed by diverged plant sesquiterpene synthases is dependent on a single residue 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2021, 卷号: 19, 期号: 30, 页码: 6650-6656
作者:  Huang,Jin-Quan;  Li,Dong-Mei;  Li,Jian-Xu;  Lin,Jia-Ling;  Tian,Xiu;  Wang,Ling-Jian;  Chen,Xiao-Ya;  Fang,Xin
浏览  |  Adobe PDF(2357Kb)  |  收藏  |  浏览/下载：84/18  |  提交时间：2022/04/02
ACTIVE-SITE RESIDUES  ARISTOLOCHENE SYNTHASE  ARTEMISIA-ANNUA  BIOLOGY  IDENTIFICATION  BIOSYNTHESIS  EXPRESSION  CLONING  GENES  
An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 105317
作者:  Munikishore,Rachakunta;  Wang,Liang-Liang;  Zhang,Shuqun;  Zhao,Qin-Shi;  Zuo,Zhili
浏览  |  Adobe PDF(523Kb)  |  收藏  |  浏览/下载：81/20  |  提交时间：2022/04/02
Cathepsin L  small-molecule inhibitor  gram-scale synthesis  KGP94  cancer  FUNCTIONALIZED BENZOPHENONE  BIOLOGICAL EVALUATION  TUMOR PROGRESSION  CELL INVASION  EXPRESSION  ANALOGS  SUPPRESSION  DERIVATIVES  ACID  
Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models 期刊论文
CELL RESEARCH, 2021, 卷号: 31, 期号: 1, 页码: 17-24
作者:  Wang,Gan;  Yang,Meng-Li;  Duan,Zi-Lei;  Liu,Feng-Liang;  Jin,Lin;  Long,Cheng-Bo;  Zhang,Min;  Tang,Xiao-Peng;  Xu,Ling;  Li,Ying-Chang;  Kamau,Peter Muiruri;  Yang,Lian;  Liu,Hong-Qi;  Xu,Jing-Wen;  Chen,Jie-Kai;  Zheng,Yong-Tang;  Peng,Xiao-Zhong;  Lai,Ren
收藏  |  浏览/下载：82/0  |  提交时间：2022/04/02
SARS  ENTRY  MERS  
Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 104767
作者:  Guo,Sheng;  Xie,Hang;  Lei,Yu;  Liu,Bin;  Zhang,Li;  Xu,Yechun;  Zuo,Zhili
浏览  |  Adobe PDF(3181Kb)  |  收藏  |  浏览/下载：99/30  |  提交时间：2022/04/02
SARS-CoV-2  Main protease  Virtual screening  Biochemical evaluation  
Non-volatile acylphloroglucinol components from Eucalyptus robusta inhibit Zika virus by impairing RdRp activity of NS5 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 105303
作者:  Yao,Zhai-Wen;  Liu,Hui;  Zhou,Rui;  Feng,Mi-Yan;  Wang,Fang;  Qin,Xu-Jie;  Chen,Xiu-Xiu;  Zheng,Chang-Bo;  Luo,Rong-Hua;  Yang,Liu-Meng;  Cen,Shan;  Xiong,Si-Dong;  Liu,Hai-Yang;  Zheng,Yong-Tang
浏览  |  Adobe PDF(2139Kb)  |  收藏  |  浏览/下载：92/30  |  提交时间：2022/04/02
Eucalyptus robusta  Acylphloroglucinol dimer  Eucalyprobusone G  Anti-ZIKV agent  NS5 RdRp  INFECTION  BINDING  GROWTH  
Which species does the virus like most: Binding modes study between SARS-CoV-2 S protein and ACE2 receptor 期刊论文
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2021, 卷号: 105, 页码: 107893
作者:  Guo,Sheng;  Yang,Jing;  Lei,Yu;  Liu,Bin;  Zhang,Wei;  Zhang,Li;  Zuo,Zhili
浏览  |  Adobe PDF(3681Kb)  |  收藏  |  浏览/下载：87/12  |  提交时间：2022/04/02
SARS-CoV-2  COVID-19  Homology modeling  Molecular dynamics simulation  Binding free energy  CORONAVIRUS SPIKE PROTEIN  ACTIVATION  GROMACS  ENTRY