Non-volatile acylphloroglucinol components from Eucalyptus robusta inhibit Zika virus by impairing RdRp activity of NS5

doi:10.1016/j.bioorg.2021.105303

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	Non-volatile acylphloroglucinol components from Eucalyptus robusta inhibit Zika virus by impairing RdRp activity of NS5
	Yao,Zhai-Wen ; Liu,Hui ; Zhou,Rui ; Feng,Mi-Yan ; Wang,Fang ; Qin,Xu-Jie ; Chen,Xiu-Xiu ; Zheng,Chang-Bo ; Luo,Rong-Hua ; Yang,Liu-Meng ; Cen,Shan ; Xiong,Si-Dong ; Liu,Hai-Yang; Zheng,Yong-Tang
	2021
发表期刊	BIOORGANIC CHEMISTRY
ISSN	0045-2068
卷号	116 页码:105303
摘要	Eucalyptus is a large genus of the Myrtaceae family with high value in various fields of industry. Recently, attention has been focused on the functional properties of Eucalyptus extracts. These extracts have been traditionally used to combat various infectious diseases, and volatile oils are usually considered to play a major role. But the positive effects of non-volatile acylphloroglucinols, a class of specialized metabolites with relatively high content in Eucalyptus, should not be neglected. Herein, non-volatile acylphloroglucinols from leaves of Eucalyptus robusta were evaluated for their abilities to inhibit Zika virus (ZIKV) which is associated with severe neurological damage and complications. The results showed eucalyprobusone G, a new symmetrical acylphloroglucinol dimer, possessed the significant ability to inhibit ZIKV without inducing cytotoxicity. The EC50 values of eucalyprobusone G against the African lineage (MR766) and Asian lineage (SZ-WIV01) of ZIKV were 0.43 +/- 0.08 and 10.10 +/- 3.84 mu M which were 110 times and 5.8 times better than those of the reference compound ribavirin, respectively. Further action mode research showed that eucalyprobusone G impairs the viral binding and RdRp activity of NS5. The results broaden the functional properties of Eucalyptus robusta and indicate acylphloroglucinol dimers could be developed as anti-ZIKV agents.
关键词	Eucalyptus robusta Acylphloroglucinol dimer Eucalyprobusone G Anti-ZIKV agent NS5 RdRp INFECTION BINDING GROWTH
DOI	10.1016/j.bioorg.2021.105303
WOS记录号	WOS:000701684500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73007
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Key Lab Bioact Peptides Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Soochow Univ, Coll Pharm, Suzhou 215021, Peoples R China 4.Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China 5.Kunming Univ Sci & Technol, Coll Med, Kunming 650500, Yunnan, Peoples R China 6.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 7.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yao,Zhai-Wen,Liu,Hui,Zhou,Rui,et al. Non-volatile acylphloroglucinol components from Eucalyptus robusta inhibit Zika virus by impairing RdRp activity of NS5[J]. BIOORGANIC CHEMISTRY,2021,116:105303.
APA	Yao,Zhai-Wen.,Liu,Hui.,Zhou,Rui.,Feng,Mi-Yan.,Wang,Fang.,...&Zheng,Yong-Tang.(2021).Non-volatile acylphloroglucinol components from Eucalyptus robusta inhibit Zika virus by impairing RdRp activity of NS5.BIOORGANIC CHEMISTRY,116,105303.
MLA	Yao,Zhai-Wen,et al."Non-volatile acylphloroglucinol components from Eucalyptus robusta inhibit Zika virus by impairing RdRp activity of NS5".BIOORGANIC CHEMISTRY 116(2021):105303.

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