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Enmein-type 6,7-seco-ent-Kauranoids from Isodon sculponeatus 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2013, 卷号: 76, 期号: 11, 页码: 2113-2119
作者:  Jiang, Hua-Yi;  Wang, Wei-Guang;  Zhou, Min;  Wu, Hai-Yan;  Zhan, Rui;  Li, Xiao-Nian;  Du, Xue;  Li, Yan;  Pu, Jian-Xin;  Sun, Han-Dong
Adobe PDF(1431Kb)  |  收藏  |  浏览/下载：526/66  |  提交时间：2014/01/21
Absolute Configuration  Diterpenoids  Terpenoids  Trichocarpus  Constituents  
Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling 期刊论文
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2013, 卷号: 13, 期号: 7, 页码: 988-994
作者:  Beevers, Christopher S.;  Zhou, Hongyu;  Huang, Shile
Adobe PDF(230Kb)  |  收藏  |  浏览/下载：193/27  |  提交时间：2013/10/16
Curcumin  Mtor  Akt  Cancer  Cell Proliferation  Cell Death  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：256/43  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Plant cyclopeptide RA-V kills human breast cancer cells by inducing mitochondria-mediated apoptosis through blocking PDK1-AKT interaction 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2013, 卷号: 267, 期号: 1, 页码: 95-103
作者:  Fang, Xian-Ying;  Chen, Wei;  Fan, Jun-Ting;  Song, Ran;  Wang, Lu;  Gu, Yan-Hong;  Zeng, Guang-Zhi;  Shen, Yan;  Wu, Xue-Feng;  Tan, Ning-Hua;  Xu, Qiang;  Sun, Yang
Adobe PDF(1855Kb)  |  收藏  |  浏览/下载：741/127  |  提交时间：2013/03/18
Ra-v  Cyclopeptide  Mitochondrial Apoptosis Pathway  Pi3k/akt  Breast Cancer  
Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction 期刊论文
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2013, 页码: 432829
作者:  Li, Shenghong;  Qiu, Shengxiang;  Yao, Ping;  Sun, Handong;  Fong, Harry H. S.;  Zhang, Hongjie
Adobe PDF(1967Kb)  |  收藏  |  浏览/下载：395/55  |  提交时间：2013/07/24
Constituents  Flavonoids